Results of EAHP’s 2019 Medicines Shortages Survey

Miljković, Nenad; Batista, Aida; Polidori, Piera; Kohl, Stephanie; Hořák, Petr

doi:10.1136/ejhpharm-2020-002341

Cited by 27 publications

(22 citation statements)

References 14 publications

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“…Moreover, cardiovascular and CNS agents in injectables were also short (Pharmacists, 2020). On the other hand, a study of EU in 2014 found that CNS drugs were most short, followed by anti-infective drugs, cardiovascular drugs, antineoplastic/immunomodulatory agents, and GIT drugs (Pauwels et al, 2014), but the EAHP survey in 2019 found that antimicrobial agents were on the top with oncology medicines second, followed by anaesthetic agents The shortage of oncology medicines increased in comparison to the data from 2018 EAHP survey (Miljković et al, 2020a).…”

Section: Drugs Reported In Shortagementioning

confidence: 94%

“…According to the UUDIS, the quality delays and capacity issues were most dominant in the United States, in 2012 followed by quality manufacturing issues and discontinuation (Figure 3) (Dill and Ahn, 2014), whereas a more significant percentage of reasons was unknown, in 2020, followed by business issues and supply/ demand issues (Figure 4) (Pharmacists, 2020). In addition, the 2019 EAHP survey found that the global shortage of APIs, manufacturing problems, and supply chain issues dominated most (Miljković et al, 2020a).…”

Section: Causes Of Drug Shortagementioning

confidence: 99%

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Drug Shortage: Causes, Impact, and Mitigation Strategies

et al. 2021

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Drug shortage is a global issue affecting low, middle, and high-income countries. Many countries have developed various strategies to overcome the problem, while the problem is accelerating, affecting the whole world. All types of drugs, such as essential life-saving drugs, oncology medicines, antimicrobial drugs, analgesics, opioids, cardiovascular drugs, radiopharmaceutical, and parenteral products, are liable to the shortage. Among all pharmaceutical dosage forms, sterile injectable products have a higher risk of shortage than other forms. The causes of shortage are multifactorial, including supply issues, demand issues, and regulatory issues. Supply issues consist of manufacturing problems, unavailability of raw materials, logistic problems, and business problems. In contrast, demand issues include just-in-time inventory, higher demand for a product, seasonal demand, and unpredictable demand. For regulatory issues, one important factor is the lack of a unified definition of drug shortage. Drug shortage affects all stakeholders from economic, clinical, and humanistic aspects. WHO established global mitigation strategies from four levels to overcome drug shortages globally. It includes a workaround to tackle the current shortage, operational improvements to reduce the shortage risk and achieve early warning, changes in governmental policies, and education and training of all health professionals about managing shortages.

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Section: Drugs Reported In Shortagementioning

confidence: 94%

Section: Causes Of Drug Shortagementioning

confidence: 99%

Drug Shortage: Causes, Impact, and Mitigation Strategies

et al. 2021

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“…A survey indicated that, despite efforts to counteract shortages, almost 92% and 95% of hospital pharmacists, respectively, reported experiencing shortages. The types of medicines most frequently in shortage were antimicrobial agents (63%), oncology medicines (47%), and anesthetic agents (38%) [ 42 ].…”

Section: Resultsmentioning

confidence: 99%

Medicine Shortages in Serbia: Pharmacists’ Standpoint and Potential Solutions for a Non-EU Country

et al. 2021

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Medicine shortages in Serbia have evidently been present for several decades, but literature data are scarce. The aim of our study was to get an insight on the present situation in Serbia, review the EU actions when managing shortages, and discern a set of potential measures. A short survey was conducted among 500 pharmacists in public pharmacies, in 23 cities in Serbia. The survey questions addressed frequency of drug shortages, professional actions in the event of shortages, main consequences to patients and pharmacies, putative causes, and pivotal measures for the prevention/mitigation of drug shortages under current conditions. Moreover, a Panel of Experts was organized, whose suggestions and opinions were used to analyze the present situation and to form a set of potential solutions and effective measures to mitigate shortages of medicines. In-depth analysis of current Serbian legislation was conducted, with emphasis on specific steps to be made within the actual legal framework. Examples of good practice in the EU, applicable to a country such as Serbia, were examined. Our research showed that although Serbia is, in some aspects, behind EU countries regarding the approaches to overcome medicine shortages, progress can be made within short period of time, by specific well-targeted actions. Both patients and pharmacists would benefit from it.

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“…The survey ran from 16 September to 23 December 2020. Data on the classes of medicines in shortage were compared with those of the 2019 survey on medicines shortages 1 to assess the impact of the pandemic on the pattern of classes of medicine shortages.…”

Section: Methodsmentioning

confidence: 99%

Lessons learnt from the COVID-19 pandemic: results of EAHP survey on the future crisis preparedness of hospital pharmacies

et al. 2021

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Aim The present survey aimed to collect information on the lessons learnt from the COVID-19 pandemic by hospital pharmacists. It focused on the shortages of health goods and the experiences of hospitals during the first phase of the crisis. Methods A 17-question survey was conducted by EAHP, looking at the experiences of hospital pharmacists during the COVD-19 pandemic. The survey ran from 16 September to 23 December 2020. Statistical analysis included backward stepwise logistic regression (BSLR), Pearson's χ 2 test, t-test and one-way ANOVA, as appropriate; p≤0.05 was considered statistically significant. Results 1466 hospital pharmacists answered the survey fully. 58%, 63% and 69% of them experienced shortages in medicines, disinfectants and personal protective equipment (PPE), respectively. BSLR showed that being a COVID-19 dedicated hospital increased the risk of medicine shortages (OR 1.63, 95% CI 1.15 to 2.31) but the shortages of disinfectants and PPE were lower (OR 0.62, 95% CI 0.44 to 0.88; OR 0.60, 95% CI 0.42 to 0.85). Being a specialised hospital reduced the odds of medicine shortages (OR 0.59, 95% CI 0.40 to 0.88), while countries with a greater percentage of the population infected had increased odds for all three types of shortages (OR 1.16, 95% CI 1.01 to 1.23; OR 1.34, 95% CI 1.19 to 1.50; OR 1.21, 95% CI 1.09 to 1.35). The odds were also higher in answers submitted in September compared with December. The classes of medicines with highest reported shortages were anaesthetics, antibiotics and muscle relaxants. The main entities that provided support were the national competent authorities and manufacturers. Conclusion Medicine shortages affected the work of hospital pharmacists during the early stages of the pandemic. The features of the crisis and the feedback described in this survey can provide interesting insights for a more resilient healthcare framework in the future.

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Results of EAHP’s 2019 Medicines Shortages Survey

Cited by 27 publications

References 14 publications

Drug Shortage: Causes, Impact, and Mitigation Strategies

Drug Shortage: Causes, Impact, and Mitigation Strategies

Medicine Shortages in Serbia: Pharmacists’ Standpoint and Potential Solutions for a Non-EU Country

Lessons learnt from the COVID-19 pandemic: results of EAHP survey on the future crisis preparedness of hospital pharmacies

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