Results of curettage for postmenopausal vaginal bleeding in women treated with tamoxifen and megestrol acetate for progressive metastatic breast carcinoma

Logmans, A.; Mous, Harold V. H.; Bontenbal, M.; Beerman, Herman; Lent, M. van

doi:10.1016/0028-2243(94)90166-x

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Cited by 6 publications

(1 citation statement)

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“…Beside its antioestrogen activity tamoxifen is known to produce adverse oestrogenic effects such as vaginal bleeding [13,14]. This is due to proliferation of the stroma [15,16] or sporadically development of endometrial tumours [17,18].…”

Section: Discussionmentioning

confidence: 99%

Chronic subdural haematoma: a possible relationship with tamoxifen

Missori

Salvati²,

Passacantilli

et al. 1998

Clinical Neurology and Neurosurgery

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Section: Discussionmentioning

confidence: 99%

Chronic subdural haematoma: a possible relationship with tamoxifen

Missori

Salvati²,

Passacantilli

et al. 1998

Clinical Neurology and Neurosurgery

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Estrogen and Progesterone Receptors in the Endometrium of Postmenopausal Breast Cancer Patients Treated with Tamoxifen and Progestogens

Cohen¹,

Altaras²,

Beyth³

et al. 1997

Gynecologic Oncology

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LC-MS/MS method for determination of megestrol in human plasma and its application in bioequivalence study

Fan

Zou

Zheng

et al. 2013

J. Huazhong Univ. Sci. Technol. [Med. Sci.]

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A rapid and highly selective liquid chromatography-tandem mass spectrometric (LC-MS/MS) method for the determination of megestrol in human plasma was described using medrysone as internal standard (IS). Blood samples were collected from 20 healthy volunteers after oral administration of 160 mg megestrol acetate dispersible tablets. The analytes were extracted by liquid-liquid extraction procedure and separated on a hanbon lichrospher column with the mobile phase of methanol and water containing 0.1% formic acid and 20 mmol/L ammonium acetate (5:1, v/v). Positive ion electrospray ionization with multiple reaction-monitoring mode (MRM) was employed by monitoring the transitions m/z 385.5-325.4 and m/z 387.5-327.4 for megestrol and medrysone, respectively. Under the isocratic separation conditions, the chromatographic run time was approximately 2.54 min for megestrol and 2.59 min for medrysone. The calibration curve range was from 0.5 to 200.0 ng/mL. The inter-batch and intra-batch precision and accuracy were less than 5.2% relative standard deviation (RSD) and 6.4% relative error (RE). The proposed method was successfully applied in the bioequivalence study of megestrol acetate dispersible tablets.

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Results of curettage for postmenopausal vaginal bleeding in women treated with tamoxifen and megestrol acetate for progressive metastatic breast carcinoma

Cited by 6 publications

References 9 publications

Chronic subdural haematoma: a possible relationship with tamoxifen

Chronic subdural haematoma: a possible relationship with tamoxifen

Estrogen and Progesterone Receptors in the Endometrium of Postmenopausal Breast Cancer Patients Treated with Tamoxifen and Progestogens

LC-MS/MS method for determination of megestrol in human plasma and its application in bioequivalence study

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