T echnological advances during the past decade have significantly enhanced our ability to successfully map and ablate ventricular arrhythmias in patients with a structurally normal heart, as well as various forms of underlying cardiac disease. Increased recognition of the deleterious effects of ventricular arrhythmias, such as the potential of frequent premature ventricular complexes (PVCs) to induce cardiomyopathy, has increased indications for ablation. Successful outcomes of catheter ablation of ventricular arrhythmias are subject to many potential challenges and reported with variable rates of success.
See Article by Rivera et alPatient selection for ablation of ventricular arrhythmias should reflect symptom severity, effect of the ventricular arrhythmia on underlying cardiac substrate, effectiveness and side effects of medical therapy, and expected safety and efficacy of ablation. Challenges to a successful ablation include lack of inducibility of the arrhythmia, inability to effectively access the ablation target (ie, intramural or epicardial location), and risk of collateral damage with ablation (ie, the coronary arteries or the conduction system). The papillary muscles create a unique challenge by presenting a target on a mobile and intracavitary structure.In a recent large-scale multicenter outcomes analysis of ablation of idiopathic PVCs, the significant predictors of procedure failure included number of PVC morphologies and PVC location. Epicardial and papillary muscle sites of origin represented the locations with lowest acute procedural success (67% and 80%, respectively). At follow-up, patients with papillary muscle PVCs had among the highest recurrence rate with only 60% of patients maintaining a successful outcome of 80% reduction in PVC burden without the use of antiarrhythmic drugs. Obstacles for both acute and long-term results for ablation of ventricular arrhythmias originating from the papillary muscles likely include the intracavitary location of the papillary muscles presenting challenges for both mapping and ablation, the constant motion of a contracting muscular structure in an already contracting chamber, and the variability of papillary muscle anatomy. The use of intracardiac echocardiography can be heplful by providing real-time visualization of the papillary muscles during mapping and ablation procedures.2 Yet, maintaining catheter contact during ablation at an identified site of origin can remain challenging using irrigated radiofrequency energy, given the constant motion of the muscular papillary apparatus. Furthermore, the thermal and mechanical effects during radiofrequency application often trigger ventricular arrhythmias that can lead to further catheter instability and dislodgement from the target tissue.In this edition of Circulation: Arrhythmia and Electro physiology, Rivera et al 3 describe a retrospective case series of 21 patients in whom papillary muscle ventricular arrhythmias were targeted with either cryoablation using an 8-mm cryocatheter or radiofrequency energy usi...