Results of conservative surgery and radiation for mammographically detected ductal carcinoma in situ (DCIS)

Characterization of a Stem-like Subpopulation in Basal-like Ductal Carcinoma in Situ (DCIS) Lesions

“…Therapeutic management of DCIS involves surgery, radiation, and where appropriate, hormonal therapies (1). Roughly 15% of patients with DCIS show recurrent disease following therapy (2). Identifying which patients are at greatest risk for disease recurrence and progression to invasive disease is a critical issue facing clinicians.…”

Factors associated with local recurrence of mammographically detected ductal carcinoma in situ in patients given breast-conserving therapy

“…Additional studies on mammographically detected DCIS treated with BCT have been reported by Fowble et al 3 and Solin et al 4 Each of those studies analyzed 110 patients who underwent lumpectomy followed by RT. No risk factors were associated significantly with recurrence in either study.…”

“…2 Although many more patients diagnosed with mammographically detected DCIS are now treated with BCT, the factors associated with optimal local control are not well defined. [3][4][5] Despite the extremely high local control and survival rates in the majority of patients, a very small (but real) percentage of patients still suffer local treatment failure and ultimately may die of their malignancy. 6 Efforts directed at defining criteria associated with local control theoretically may lead to a reduction in the rate of mortality in these patients.…”

Salvage treatment for local recurrence after breast-conserving surgery and radiation as initial treatment for mammographically detected ductal carcinoma in situ of the breast

“…4 -10,39 Additionally, many of the patients included in the current study have been included in reports of previous single or limited institution studies. [11][12][13][14][15][16][17][18][19][20][21][22][23][24][25][26][27][28][29][30] An analysis has been performed of a cohort of 422 mammographically detected intraductal breast carcinomas in 418 women who were treated initially with breast-conserving surgery and definitive breast irradiation between 1973 and 1990. The outcome after treatment at the time of initial diagnosis of DCIS has been reported in detail.…”