Results of Complex Immunopharmacological Analysis of the Mechanisms of Action of Bioregulation Agents

Казимирский, А. Н.; Салмаси, Ж. М.; Poryadin, G. V.; Кукес, И. В.

doi:10.1007/s10517-021-05326-w

Cited by 1 publication

(2 citation statements)

References 13 publications

(18 reference statements)

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“…Magnetophoresis is a transdermal method (transdermal therapeutic system, TTS) for supporting drug penetration through biological barriers, which was used together with ketoprofen gel, achieving a positive analgesic effect that persisted even after 30 days (biological hysteresis phenomenon) [ 13 ]. The assumption of this study was to use an enhanced physical factor of magnetic stimulation plus LED therapy [ 14 ] in the form of magnetoledophoresis accompanied by the use of an ointment, with previously proven effectiveness [ 15 ].…”

Section: Introductionmentioning

confidence: 99%

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Analgesic Effectiveness of Physical Therapy Combining the Use of Electromagnetic Fields with Light Radiation Emitted by LEDs along with the Use of Topical Herbal Ointment in Patients with Gonarthrosis

Janczewska

Koszela

Klimkiewicz

et al. 2023

IJERPH

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(1) Background: The aim of the study is to evaluate the analgesic effectiveness of a physical therapy regimen that combines the use of an electromagnetic field with light radiation emitted by LEDs, along with the use of Traumeel S ointment, in patients with gonarthrosis. (2) Methods: The study included 90 patients with knee osteoarthritis (grade 2 Kellgren and Lawrence osteoarthritis). They were divided into three groups: Group I, 30 patients treated with magnetic stimulation plus LED therapy; Group II, 30 patients treated with Traumeel S ointment; and Group III, 30 patients treated with magnetic stimulation plus LED therapy with Traumeel S ointment. Pain intensity was assessed using the VAS and Laitinen scales before and after a series of treatments. (3) Results: Significant results in terms of pain reduction before and after treatment were obtained in each of the study groups, as there were significant differences in the VAS pain intensity scores before and after the procedures between the groups. In group I, with electromagnetic field and LED light treatment, the difference was 35.5; in group II, which received Traumeel S® ointment, the difference was 18.5; and in group III, with electromagnetic field and LED light treatment as well as Traumeel S ointment, the difference was 26.5. In the Laitinen scale, the differences were insignificant, although the size distribution was similar. (4) Conclusions: The therapy used in this study showed that magnetic stimulation plus LED therapy and the use of Traumeel S ointment gave positive results in terms of pain reduction in each of the study groups. The strongest analgesic factor seems to be magnetic and LED therapies used separately. Traumeel S in magnetoledophoresis does not work synergistically with the magnetic field of LED light, and even worsens the effect of the therapy used.

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Section: Introductionmentioning

confidence: 99%

“…Traumeel S is an ointment that works based on plant and mineral ingredients in a different way than do NSAIDs. It has been found that Traumeel S reduces the activity of NADPH oxidase and extracellular neutrophil traps, and also induces an anti-inflammatory effect on lymphocyte subpopulations [ 15 ].…”

Section: Introductionmentioning

confidence: 99%