Results of common laboratory tests in solvent-exposed workers

Kaukiainen, Ari; Vehmas, Tapio; Rantala, Kaarina; Nurminen, Markku; Martikainen, Rami; Taskinen, Helena

doi:10.1007/s00420-003-0476-z

Cited by 56 publications

(37 citation statements)

References 32 publications

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“…Despite the fact that some of these compounds are not considered carcinogenic by the International Agency for Research on Cancer (IARC), a mixture of them or some individual metals can contribute to increase the risk of cancer [4,5], neurological issues [6], hearing loss [7], and hepatic [8] and respiratory [9] diseases. The exact mechanism of such damages is not fully understood, but it is known that occupational exposure to organic solvents [3,[10][11][12] and some metals [13][14][15] can induce oxidative stress and DNA damages.…”

Section: Introductionmentioning

confidence: 99%

Occupational risk assessment of oxidative stress and genotoxicity in workers exposed to paints during a working week

Cassini

Calloni

Bortolini

et al. 2011

International Journal of Occupational Medicine and Environmental Health

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Objectives: Paints are complex mixtures of solvents and metals that can induce health damages in workers exposed to them. The aim of the present work was to evaluate possible oxidative and genotoxic effects in workers exposed to paints. Material and Methods: Peripheral blood and buccal cell samples were collected from 33 workers exposed to paints and 29 non-exposed workers (controls) during an ordinary working week (Monday morning and Friday evening). Oxidative markers were assessed using thiobarbituric acid assay, carbonylated proteins, superoxide dismutase and catalase activities. Hippuric acid and delta-aminolevulinic acid were determined as biomarkers of toluene and lead exposure, respectively. Genotoxicity was measured through comet assay and micronucleus (MN) frequencies. Results: The exposed group showed higher hippuric acid and delta-aminolevulinic acid levels (Friday samples) and lower superoxide dismutase activity (Monday samples) in relation to control group. DNA damage index (comet assay) was higher in the exposed group, both in Monday and Friday samples, compared to the control group. No differences were observed in frequency of micronuclei (MN) between the groups, either in lymphocytes or buccal cells. However, the exposed group presented an increase (Monday samples) in nuclear buds frequency in lymphocytes -a marker of gene amplificationas well as an increase in condensed chromatin in the buccal cells (Monday and Friday samples), suggesting induction of apoptosis. Furthermore, a decrease in the nuclear division index (Friday samples) was observed in the exposed group, indicating that paint exposure induces cytostatic effects in lymphocytes. Conclusion: The results suggest that individuals exposed to paints have increased levels of DNA damage.

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Section: Introductionmentioning

confidence: 99%

Occupational risk assessment of oxidative stress and genotoxicity in workers exposed to paints during a working week

Cassini

Calloni

Bortolini

et al. 2011

International Journal of Occupational Medicine and Environmental Health

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“…In particular, solvent related chronic encephalopathy (SRCE) has been described in several studies 1,8,9) . Toxic effects of organic solvents were reported to harm liver 10) , kidney 11) and skin 12) .…”

Section: Introductionmentioning

confidence: 99%

Exposure to Organic Solvents among Handicraft Car Painters: A Pilot Study in Italy

Vitali¹,

Ensabella²,

Stella³

et al. 2006

Ind Health

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Car repair painters usually experience long-term exposure to many different solvents. In Italy, the greater part of car painting shops are "handicraft", i.e. 2-5 workers and small premises. Usually workers do not have specific duties, but everyone takes part in all different operations. Moreover, working time is not standardized but varies according to the workload, working methods tend to be traditional, and compliance to individual protection devices is poor. We have hence assessed, on a sample of 8 italian handicraft car painting shops, the exposure levels to solvents, implementing three classic exposure monitoring methods: environmental sampling with charcoal tubes, personal sampling with diffusive charcoal samplers, and urinary determination of unmetabolised solvents. A simple regression analysis was performed to evaluate relationships between the three series of data. The solvents analysed were toluene, ethylbenzene, 1, 2-dichloropropane, n-butylacetate, n-amylacetate, xylene isomers, ethylacetate, and benzene. Benzene was included due to several factors, among others its presence (1% v/v) in the italian unleaded gasoline. Benzene was found in all shops, at levels around or higher than the 8-h timeweighted average limit (8-h TLV-TWA). Other solvents were found in the different shops at various levels, 10 2 -10 1 times the 8-h TLV-TWA. Air concentrations of toluene, n-butylacetate, xylenes, and benzene were positively correlated with urinary levels of the parent compounds, while a negative correlation was found for ethylbenzene. The health implications of workers' exposure level was briefly discussed.

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“…Exposure to organic solvents has been associated with neurological effects [Ritchie et al, 2001;Yu et al, 2004], genotoxic effects [Roma-Torres et al, 2006], multiple system health effects [Kaukiainen et al, 2004], cancer [Guo et al, 2004;Strom et al, 2005;Clapp et al, 2008], and liver and kidney damage. In this study, although we did not measure the health effects of solvent exposure, we did survey farmers on their perceived risk of exposure and related illness in the family.…”

Section: Discussionmentioning

confidence: 99%

Farmer exposure to organic solvents during the maintenance and repair of farm machinery: A pilot study

Bunn

Liu

Lee

et al. 2009

American J Industrial Med

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Results of common laboratory tests in solvent-exposed workers

Cited by 56 publications

References 32 publications

Occupational risk assessment of oxidative stress and genotoxicity in workers exposed to paints during a working week

Occupational risk assessment of oxidative stress and genotoxicity in workers exposed to paints during a working week

Exposure to Organic Solvents among Handicraft Car Painters: A Pilot Study in Italy

Farmer exposure to organic solvents during the maintenance and repair of farm machinery: A pilot study

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