Results of Boceprevir and Telaprevir Combination Therapy in Chronic Hepatitis C Patients in Nevşehir Province

Abstract

ÖZET Kronik hepatit C infeksiyonu Anahtar sözcükler: Boceprevir, hepatit C infeksiyonu, proteaz inhibitörü, telaprevir SUMMARY Results of Boceprevir and Telaprevir Combination Therapy in Chronic Hepatitis C Patients in Nevşehir Province Chronic Hepatitis C infection is an important health problem in Turkey. The most frequently observed hepatitis C virus (HCV) genotype in Turkey is genotype 1b. Protease inhibitor antiviral agents boceprevir (BOC) and telaprevir (TVR) for HCV infection are one of the major advances in its medical treatment. The combination of BOC and TVR with pegylated interferonalpha and ribavirin (PegIFN/RBV) for the treatment of patients infected with HCV genotype 1 has caused significantly increased rates of sustained virologic response (SVR