Results of Blood Inflammatory Markers Are Associated More Strongly With Toe-Brachial Index Than With Ankle-Brachial Index in Patients With Type 2 Diabetes

Aso, Yoshimasa; Okumura, Ki-ichi; Inoue, Teruo; Matsutomo, Rika; Yoshida, Noboru; Wakabayashi, Shigeo; Takebayashi, Kohzo; Iwamoto, Toshihiko

doi:10.2337/diacare.27.6.1381

Cited by 29 publications

(25 citation statements)

References 26 publications

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“…This study found no correlation between serum lipid and ABI values, which is consistent with findings for studies of a hemodialysis population, [18] diabetic population, [20,21] and general population. [14] However, Newman et al demonstrated that hyperlipidemia was associated with low ABI value in an elderly population (77±6 years).…”

Section: Ankle-brachial Indexsupporting

confidence: 91%

Atherosclerotic Risk Factors Among Ankle-Brachial Index and Toe-Brachial Index in Peritoneal Dialysis Patients

et al. 2007

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Background. Atherosclerotic vascular change affecting the lower extremities is the most common peripheral vascular disease. Ankle-brachial index (ABI) and toe-brachial index (TBI) are common, non-invasive diagnostic tests for atherosclerosis in the lower extremities. Peritoneum is a vascular-based structure. The use of glucose-based hyperosmolar solutions for PD patients results in a significant increase in blood glucose load and can be considered atherogenic. The association between ABI or TBI values and peritoneal function in patients undergoing peritoneal dialysis remains unclear. We presumed that the risk factors for atherosclerosis in large and small vessels may differ. Methods. A total of 146 peritoneal dialysis patients, 41 males and 105 females (119 without diabetes and 27 with diabetes), received peritoneal dialysis for more than four months. Patients who had dialysis-related peritonitis within six months prior to this study were excluded. The ABI or TBI was determined using an automated, non-invasive, waveform analysis device. Results. The ABI value correlated positively with mean arterial pressure and TBI value. The TBI value correlated positively with ABI value and inversely with fasting serum glucose and serum total cholesterol concentrations. Peritoneal function was not correlated with ABI or TBI. Conclusion. This cross-sectional study demonstrated that risk factors in peritoneal dialysis patients for atherosclerosis in large vessels and small vessels differed. Interestingly, peritoneal function test is not associated with ABI or TBI value. However, further investigation of the association between ABI or TBI value and cardiovascular events is required for this patient group.

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Section: Ankle-brachial Indexsupporting

confidence: 91%

Atherosclerotic Risk Factors Among Ankle-Brachial Index and Toe-Brachial Index in Peritoneal Dialysis Patients

et al. 2007

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“…Yoshimasa Aso et al, [10] who studied the association of TBI and ABI with multiple blood markers of inflammation such as hsCRP, IL-6, and fibrinogen, found a significant negative correlation of TBI but not ABI with the serum hsCRP. They suggested that the falsely high ABI (>1.3) values which were due to a medial arterial calcification may account for the absence of a significant correlation between hsCRP and the ABI in the diabetic patients.…”

Section: Discussionmentioning

confidence: 99%

“…These blockages restrict the blood circulation, mainly in the arteries, leading to blockages in the kidneys, stomach, arms, legs and feet [8,9]. Since ABI is said to be a marker of the atherosclerotic burden, the low ABI in Type 2 DM often indicates a significant atherosclerosis in the vascular beds [10]. Thus, ABI can be considered as a suitable method for assessing PVD.…”

Section: Introductionmentioning

confidence: 99%

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A Study of Association of Ankle Brachial Index (ABI) and the Highly Sensitive C - Reactive Protein (hsCRP) in Type 2 Diabetic Patients and in Normal Subjects

Kumar¹

2013

JCDR

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Background: The Ankle-Brachial Index (ABI) objectively assesses the lower extremity arterial perfusion. A low ABI suggests atherosclerosis and Peripheral Arterial Disease (PAD). PAD is more common in individuals with type2 Diabetes mellitus (Type2 DM). Inflammatory markers are found to be associated with Type2 DM. But the association of the inflammatory markers with the atherosclerotic burden remains poorly defined. Aims:To compare the ABI and the hsCRP in the Type 2 DM patients with those in the normal subjects and to study the association of serum hsCRP with ABI in the Type 2 DM patients and in normal subjects. Methods:The subjects were 40 Type2 DM and 40 age, sex and BMI matched normal subjects who were aged between 45-60 yrs. The subjects were assigned to two different groups, Group1-the Type2 DM patients and Group2-the healthy controls. The serum hsCRP levels were determined by the turbidimetry method (BIOSYSTEMS) and the ABI values were determined by using the traditional continuous wave (CW) Doppler of NICOLET VERSALAB.Statistical Analysis: The data was analyzed by using the Student's t test (two tailed; independent) to find the significance of the study parameters between the two groups. Pearson's Correlation was used to find the correlation of serum hsCRP with the ABI in the two groups.

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“…Sheen et al 11 reported that low eGFR was a major determinant of low TBI, as well as low ABI; however, eGFR was associated more strongly with TBI than with ABI in patients with type 2 diabetes. Moreover, Aso et al 16 reported that serum inflammatory marker, including C-reactive protein, showed significant negative correlation with TBI but not with ABI.…”

Section: Discussionmentioning

confidence: 99%

Toe–brachial index is associated more strongly with albuminuria or glomerular filtration rate than ankle–brachial index in patients with type 2 diabetes

et al. 2012

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The aim of this study was to investigate whether toe-brachial index (TBI) is more strongly associated with albuminuria or estimated glomerular filtration rate (eGFR) than ankle-brachial index (ABI), and thus is a more suitable tool for evaluating the association between peripheral artery disease (PAD) and diabetic nephropathy than ABI in patients with type 2 diabetes. We evaluated the relationships between ABI or TBI and the degree of urinary albumin excretion or eGFR, as well as the major cardiovascular risk factors, in 390 patients with type 2 diabetes. Furthermore, we compared the area under the receiveroperator characteristic curve (AUC) of TBI or ABI for albuminuria or chronic kidney disease (CKD). Low-density lipoprotein cholesterol was negatively associated with ABI. Age and duration of diabetes were negatively associated with TBI, and diastolic blood pressure and high-density lipoprotein cholesterol were positively associated with TBI. Log (urinary albumin excretion) was associated more strongly with TBI (r¼À0.265, Po0.0001) than with ABI (r¼À0.132, P¼0.0111), and eGFR was positively associated with TBI (r¼0.195, P¼0.0002) but not with ABI (r¼0.023, P¼0.6571). The AUCs of TBI for albuminuria (P¼0.0002) and CKD (P¼0.0322) were significantly greater than those of ABI. In conclusion, TBI is associated more strongly with albuminuria and eGFR than ABI in patients with type 2 diabetes. Our study suggests that TBI may be a more suitable tool for evaluating the association between PAD and diabetic nephropathy than ABI in patients with type 2 diabetes.

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Results of Blood Inflammatory Markers Are Associated More Strongly With Toe-Brachial Index Than With Ankle-Brachial Index in Patients With Type 2 Diabetes

Cited by 29 publications

References 26 publications

Atherosclerotic Risk Factors Among Ankle-Brachial Index and Toe-Brachial Index in Peritoneal Dialysis Patients

Atherosclerotic Risk Factors Among Ankle-Brachial Index and Toe-Brachial Index in Peritoneal Dialysis Patients

A Study of Association of Ankle Brachial Index (ABI) and the Highly Sensitive C - Reactive Protein (hsCRP) in Type 2 Diabetic Patients and in Normal Subjects

Toe–brachial index is associated more strongly with albuminuria or glomerular filtration rate than ankle–brachial index in patients with type 2 diabetes

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