Results of an attempt to reproduce the STAP phenomenon

Aizawa, Shinichi

doi:10.12688/f1000research.8731.1

Cited by 5 publications

(1 citation statement)

References 9 publications

(21 reference statements)

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“…Open Science Framework: Dataset: Results of an attempt to reproduce the STAP phenomenon, doi 10.17605/OSF.IO/48f2z ( Aizawa, 2016 ).…”

Section: Data Availabilitymentioning

confidence: 99%

Results of an attempt to reproduce the STAP phenomenon

Aizawa¹

2016

F1000Res

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In 2014, Obokata and colleagues reported their observation of a novel cell reprogramming phenomenon they named 'stimulus-triggered acquisition of pluripotency' (STAP). The most conclusive evidence for the pluripotency of so-called STAP cells was the purported ability of such cells to contribute to chimera formation. Here, I report the results of an attempt by Haruko Obokata to replicate the phenomenon under the supervision of the Scientific Validity Examination Team of RIKEN. In this follow-up study, putative STAP cells prepared by Haruko Obokata were injected into 1051 embryos, of which 591 were recovered. However, the injected cells made no significant contribution in any of the embryos that developed.

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“…Open Science Framework: Dataset: Results of an attempt to reproduce the STAP phenomenon, doi 10.17605/OSF.IO/48f2z ( Aizawa, 2016 ).…”

Section: Data Availabilitymentioning

confidence: 99%

Results of an attempt to reproduce the STAP phenomenon

Aizawa¹

2016

F1000Res

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Expression of SSEA-4 and Oct-4 from somatic cells in primary mouse gastric cell culture induced by brief strong acid

2021

Mol Cell Biochem

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Pluripotent Stem Cells in Adult Tissues: Struggling To Be Acknowledged Over Two Decades

Bhartiya

2017

Stem Cell Rev and Rep

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Stem cells have fascinated scientists for a long time and huge research efforts have been put into them as they have the potential to regenerate diseased organs. Besides embryonic stem cells (ES) and induced pluripotent stem cells (iPS), it has been postulated that pluripotent stem cells (PSCs) may also exist in various adult tissues. They are thought to be more primitive than the adult stem cells (ASCs), serve as a backup pool to give rise to ASCs and thus play a crucial role in maintaining life-long homeostasis. These PSCs could also be the embryonic stem cells in adult tissues that were proposed to initiate cancers according to the Embryonic Rest Hypothesis put forth in the nineteenth century. However, the very presence of PSCs in adult tissues is mired with controversies. This article is a sincere attempt to review research carried out by various investigators over the last two decades and various attempts to demonstrate their presence in adult tissues. Such adult PSCs could be the ideal stem cell candidates to bring about endogenous regeneration compared to ES/iPS cells grown in Petri dish and also score better over ASCs which in fact are tissue committed progenitors with limited regenerative potential that differentiate from the PSCs. PSCs in adult tissues have remained elusive until now as they possibly get unknowingly discarded due to their small size and inability to pellet at 1000-1200 rpm (250 g). They will likely prove to be a game changer in the field of stem cells biology, for regenerative medicine and for our understanding of cancer initiation.

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Results of an attempt to reproduce the STAP phenomenon

Cited by 5 publications

References 9 publications

Results of an attempt to reproduce the STAP phenomenon

Results of an attempt to reproduce the STAP phenomenon

Expression of SSEA-4 and Oct-4 from somatic cells in primary mouse gastric cell culture induced by brief strong acid

Pluripotent Stem Cells in Adult Tissues: Struggling To Be Acknowledged Over Two Decades

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