Results of ambulatory pH monitoring do not reliably predict response to therapy in patients with eosinophilic oesophagitis

Francis, Dawn L.; Foxx‐Orenstein, Amy E.; Arora, Amindra S.; Smyrk, Thomas C.; Jensen, Kimberly L.; Nord, Sara Linker; Alexander, Jeffrey A.; Romero, Yvonne; Katzka, David A.

doi:10.1111/j.1365-2036.2011.04922.x

Cited by 84 publications

(65 citation statements)

References 17 publications

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“…Efforts to further distinguish EoE from PPI-REE have proven difficult. Endoscopic and clinical characteristics appear to be similar [58]. Earlier studies by Francis et al have shown that even ambulatory pH monitoring is not reliable in predicting response to PPI [59].…”

Section: Proton Pump Inhibitor Responsive Esophageal Eosinophiliamentioning

confidence: 77%

Eosinophilic Esophagitis: A Comprehensive Review

Nt¹

2016

J Hepatol Gastroint Dis

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Eosinophilic Esophagitis (EoE) has been the subject of intense research and study over the past few years, as incidence and prevalence has increased in the United States, especially in adults. The signs, symptoms and complications of EoE arise from a complex interplay of genetic predisposition and environmental exposure that is not understood well at this time. The disease causes significant morbidity in both physical and psychological areas, and these effects may become permanent in some cases where remodeling of the epithelium is present. Treatment at this time mainly focuses on diet, medication and endoscopic dilation. While none of these entities can accomplish all of the treatment goals, careful selection of patients based on symptoms and physical findings can alleviate many of the complications of the disease. In addition, this review attempts to cull data from adult studies if possible, as much of the studies that involved children did not translate well to adult patients.

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Section: Proton Pump Inhibitor Responsive Esophageal Eosinophiliamentioning

confidence: 77%

Eosinophilic Esophagitis: A Comprehensive Review

Nt¹

2016

J Hepatol Gastroint Dis

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“…Second, a discrepancy exists between symptomatic and histologic remission. Some patients do not present symptom relief even after endoscopic and histological improvement has been achieved [59,110,111]. This discrepancy is likely attributed to the limited response of the sub-epithelial fibrosis and remodeling to the currently available medication.…”

Section: Treatmentmentioning

confidence: 85%

“…However, subepithelial fibrosis or muscle dysfunction is difficult to detect by a conventional endoscopic approach with a biopsy. This may partially explain the discrepancy between the degree of clinical symptoms and the severities of endoscopic abnormalities or histological eosinophilic inflammation in EoE [59][60][61][62]. Esophageal foreign body impaction is a major GI emergency in Western countries, where EoE with food impaction is more common.…”

Section: Clinical Manifestationsmentioning

confidence: 99%

Diagnosis and treatment of eosinophilic esophagitis in clinical practice

Abe

Sasaki

Yagi

et al. 2017

Clin J Gastroenterol

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“…Current thinking suggests that eosinophilic oesophagitis is an immune-mediated, antigen-driven disorder; 3 thus, diet elimination and/or corticosteroid therapy would seem the fitting therapeutic strategy. 4 There is now, however, confirmatory evidence available, including our study 2 and their data, 5,6 as well as other studies, [7][8][9][10][11][12][13][14][15] that symptomatic patients with oesophageal eosinophilic infiltration, which is phenotypically indistinguishable from eosinophilic oesophagitis, respond to PPI therapy. In further support of Drs.…”

mentioning

confidence: 85%