Results of a prospective multicenter neuroendocrine tumor registry reporting on clinicopathologic characteristics of Greek patients

Nikou, George C.; Pazaitou‐Panayiotou, Kalliopi; Dimitroulopoulos, Dimitrios; Alexandrakis, Georgios; Papakostas, Pavlos; Vaslamatzis, Michalis; Kaldrymidis, Philippos; Markussis, Vyron; Koumarianou, Anna

doi:10.1186/s12902-016-0089-7

Cited by 10 publications

(11 citation statements)

References 31 publications

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“…The median age of the patients at our study was 55.7 years, similar to other studies (Niederle et al, 2010;Araujo et al, 2013;Lewkowicz et al, 2015;Nikou et al, 2016). Five percent of the cases were asymptomatic.…”

Section: Discussionsupporting

confidence: 89%

“…Grade and Ki-67 ratio are required for pathologic classification and have prognostic significance. The Ki67 ratio was found to be <2% in most of the studies (Garcia-Carbonero et al, 2010;Niederle et al, 2010;Lim et al, 2011;Araujo et al, 2013;Lewkowicz et al, 2015;Nikou et al, 2016;Lim et al, 2017). Likewise, in our study, the Ki67 rate was found to be ≤2% in 63.1%, 3-20% in 7.1%, and >20% in 25% of patients.…”

Section: Discussionsupporting

confidence: 73%

“…The pancreas and lung were the most common primary localizations in the study by Nikou et al, (2016). In another study, the most common primary localizations were alined as rectum, duodenum, pancreas and stomach while the most frequent stage, grade and metastatic site were stage 1, grade 1 and the liver, respectively (Lim et al, 2017).…”

Section: Discussionmentioning

confidence: 84%

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Factors Affecting Survival in Neuroendocrine Tumors: A 15-Year Single Center Experience

Sakin

Tambaş

Seçmeler

et al. 2018

Asian Pac J Cancer Prev

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Background: Neuroendocrine tumors are a heterogeneous group of tumors that can originate from all of the neuroendocrine cells in the body, mostly from the gastrointestinal tract. In addition to early diagnosis, streaming patients into appropriate prognostic groups is an important component of treatment. In this study, we examined the factors that affect survival in patients we followed in our center between 2000-2016. Methods: The demographic data, clinical and pathological features of patients were obtained from their medical files. TNM staging and tumor grading were performed according to AJCC and WHO 2010 classification. SPSS 15.0 for Windows programme was used for statistical analysis. Results: 85 patients (32 male, 53 female) were included into the study. The median age of the patients was 55,7 (27-83) years. Eighty percent of the tumors were of gastroenteropancreatic system, most commonly stomach (27.1%) origin. Nineteen patients (22.4%) died during follow-up. In univariate analysis; age (p<0,001), stage (p=0.002), primary tumor localization (p=0.005), grade (p<0.001), Ki-67 value (p<0.001), number of metastases (p=0.001) and type of surgery (p<0.001) were found to be factors affecting survival. Age (p=0.024) and Ki67 (p <0.001) were the independent prognostic factors for survival in multivariate analysis. For the cut-off value of 6%, Ki-67 had a sensitivity of 83.3% and specifity of 71.4% for survival determination. Conclusion: Ki-67 ratio and age were the most important factors affecting survival in neuroendocrine tumors in our study. Ki-67 ratio has a high sensitivity and specificity for predicting survival, a cut-off value of 6% may be used to predict survival.

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Section: Discussionsupporting

confidence: 89%

Section: Discussionsupporting

confidence: 73%

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Factors Affecting Survival in Neuroendocrine Tumors: A 15-Year Single Center Experience

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Tambaş

Seçmeler

et al. 2018

Asian Pac J Cancer Prev

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“…Our results provide a comprehensive and relevant information on a group of neoplasm still poorly characterized, particularly, in Southern Europe. Published data from GEP-NEN in European countries is available in a French registration study [7], in a Spanish study of the Neuroendocrine Tumours Study Group Registry of Spain (RGETNE) [8], in an Italian epidemiological study [9], in a prospective Greek registry [10], and in the United Kingdom and Northern European countries [11–13]. Worldwide, the most characterized cohorts are from the United States of America (USA) [2, 14], and there is data available from Asian countries, such as China [15] and Japan [16].…”

Section: Discussionmentioning

confidence: 99%

Gastroenteropancreatic Neuroendocrine Neoplasia Characterization in Portugal: Results from the NETs Study Group of the Portuguese Society of Endocrinology, Diabetes and Metabolism

Santos

Vinagre

Soares

et al. 2019

International Journal of Endocrinology

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Background. The incidence of gastroenteropancreatic neuroendocrine neoplasms (GEP-NENs) has been increasing in the last five decades, but there is no large-scale data regarding these tumours in Portugal. We conducted a cross-sectional, multicentric study in main Portuguese centers to evaluate the clinical, pathological, and therapeutic profile of GEP-NENs. Methods. From November, 2012, to July, 2014, data from 293 patients diagnosed with GEP-NENs from 15 centers in Portugal was collected and registered in an online electronic platform. Results. Median age at diagnosis was 56.5 (range: 15-87) years with a preponderance of females (54.6%). The most frequent primary sites were the pancreas (31.1%), jejunum-ileum (24.2%), stomach (13.7%), and rectum (8.5%). Data regarding hormonal status was not available in most patients (82.3%). Stratified by the tumour grade (WHO 2010 classification), we observed 64.0% of NET G1, 24.7% of NET G2, and 11.3% of NEC. Poorly differentiated tumours occurred mainly in older patients (p=0.017), were larger (p<0.001), and presented more vascular (p=0.004) and lymphatic (p=0.001) invasion. At the time of diagnosis, 44.4% of GEP-NENs presented metastatic disease. Surgery (79.6%) and somatostatin analogues (30.7%) were the most frequently used therapies of GEP-NENs with reported grading. Conclusion. In general, Portuguese patients with GEP-NENs presented similar characteristics to other populations described in the literature. This cross-sectional study represents the first step to establish a national database of GEP-NENs that may aid in understanding the clinical and epidemiological features of these tumours in Portugal.

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“…Despite their identification over a century ago, the natural history of NENs remains inadequately understood. Their rarity, heterogeneity, and unique phenotypic, hormonally driven variation, expressed by nonspecific but debilitating symptoms, hamper efforts to totally understand their biological characteristics [2,[4][5][6]. However, according to the largest and most recent population-based study of NENs conducted in the United States, the incidence and prevalence of NENs have continued to rise over time, rendering their closest investigation imperative [2].…”

Section: Introductionmentioning

confidence: 99%

The Diagnostic Value of Chromogranin A in Neuroendocrine Neoplasms is Potentiated by Clinical Factors and Inflammatory Markers

et al. 2020

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Objective: Neuroendocrine neoplasms (NENs) are a heterogenous group of indolent tumors, with variable clinical behavior and steadily rising incidence. The aim of this study is to investigate the clinical and laboratory factors that contribute in predicting the aggressiveness and invasiveness of NENs. Special focus is given to clinical parameters that would enhance the diagnostic value of chromogranin A (CgA), via formalizing an integrated probability model, which would contribute to the timely and accurate identification of patients at high risk for metastatic disease at initial diagnosis. Designs and Methods: We identified a total of 93 patients with NENs, recruited at a specialized academic center in Athens, Greece. Anthropometric, clinical, laboratory, and pathological data were obtained from every patient before any therapeutic intervention. Results: Age over 50 years and male gender were accompanied by increased risk for metastases at the time of initial diagnosis. Additionally, when these parameters were combined with CgA levels, they were shown to enhance the predictive capacity of CgA. Different patient scenarios combining age, gender, and CgA levels are associated with different probabilities for metastatic disease, demonstrated schematically in a gradually escalating model, as age and CgA levels increase in both males and females. The lowest risk is observed in women aged <50 years old with CgA levels <200 ng/dl (6.5%), while the highest one is in males over 50 years old with CgA > 200 ng/dl (62.9%). Finally, it was shown that c-reactive protein (CRP) can predict disease extent at the time of diagnosis. Conclusions: CgA levels can not only be used as a direct predictor of tumor load in patients with NENs, but also, when interpolated with the effects of age and gender, cumulatively predict whether a NEN would be metastatic or not at the time of initial diagnosis, via a risk-escalating probability model.

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Results of a prospective multicenter neuroendocrine tumor registry reporting on clinicopathologic characteristics of Greek patients

Cited by 10 publications

References 31 publications

Factors Affecting Survival in Neuroendocrine Tumors: A 15-Year Single Center Experience

Factors Affecting Survival in Neuroendocrine Tumors: A 15-Year Single Center Experience

Gastroenteropancreatic Neuroendocrine Neoplasia Characterization in Portugal: Results from the NETs Study Group of the Portuguese Society of Endocrinology, Diabetes and Metabolism

The Diagnostic Value of Chromogranin A in Neuroendocrine Neoplasms is Potentiated by Clinical Factors and Inflammatory Markers

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