Results of a pilot study of endoscopic screening of first degree relatives of colorectal cancer patients in Italy.

Participation in screening colonoscopy in first-degree relatives from patients with colorectal cancer

“…A recent study from France has investigated the compliance for colonoscopy screening in first-degree relatives of patients with large adenoma [13] and has shown a low compliance rate of approximately 18% among first-degree relatives of individuals with large adenomas. A number of different studies investigated the effectiveness of colonoscopy screening in first-degree relatives from patients with colon cancer [14][15][16][17]. However, these studies were done as part of a clinical study or research program, as opposed to our study, which reflects the situation among the general population.…”

“…In addition, this registry arranges improved cooperation in interdisciplinary treatment and accelerates communication between inpatient and outpatient medical care. Therefore our study differed from other investigations in which relatives from patients with colorectal cancer where invited to enroll in screening colonoscopies [14][15][16][17]. The main focus of this investigation was to determine the impact of current screening recommendations in the general population.…”

Screening for familial colorectal cancer with a sensitive immunochemical fecal occult blood test: a pilot study

“…Participation in CRC screening has been reported higher in the family risk than in the average-risk population [26]. However, colonoscopy compliance in first-degree relatives of patients with CRC is still unsatisfactory with a poor participation rate [8,23]; Codori et al [8], found that only 60% of participants underwent colonoscopy in a survey of more than 1000 first-degree relatives of CRC patients. This rate of participation is even lower in first-degree relatives of patients with advanced adenomas [9].…”

“…In fact, no prospective studies have been performed to compare the efficacy of colonoscopy with other screening strategies in patients with a family history of CRC. Colonoscopy is far from being an ideal screening test as it is expensive, requires skilled endoscopists, might lead to life-threatening complications, and compliance rates are lower than 60% in first-degree relatives of patients with CRC [8,22,23] and only 18% for families of patients with large adenomas [9].…”

Colorectal cancer screening in the familial risk population: Is colonoscopy still the strategy of choice?

“…Indeed, colonoscopy participation was higher in younger age groups in two studies compared with older adults. 60,61 High educational level was associated with greater screening participation in three out of eight studies, but the remaining others found no such association. 59 Strong family history has been consistently associated with CRC screening behavior.…”