Results of a follow-up investigation to a clinical trial testing the efficacy of clomipramine in the treatment of separation anxiety in dogs

King, J. N.; Overall, Karen L.; Appleby, David; Simpson, Barbara S.; Béata, Claude; Chaurand, C.J.P.; Heath, Sarah; Ross, Colin A.; Weiss, A.B.; Müller, G; Bataille, B.; Paris, Timothy; Pageat, Patrick; Brovedani, Fabienne; Garden, C.; Petit, S.

doi:10.1016/j.applanim.2004.06.003

Cited by 28 publications

(10 citation statements)

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“…In our clinic, the atypical antidepressant trazodone hydrochloride has been used as an effective adjunctive agent to fill this niche. 11 First synthesized in Italy in 1966, trazodone has been used for many years in human patients as a welltolerated antidepressant, 12,13 antiobsessional agent, 14 and anxiolytic. 15 It may be less effective than other agents in the treatment of acute panic disorder.…”

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confidence: 99%

“…32 Although trazodone has an extensive history of use in humans, little clinical data are available on the use of this drug in dogs. 3,8,11 The objectives of the present study were to evaluate use of trazodone hydrochloride as an adjunctive treatment for anxiety disorders in dogs unresponsive to other pharmacologic agents as well as evaluate treatment protocol, dose range, concurrent drug use, adverse events, and therapeutic response during 12 years of use in a clinical outpatient behavior practice.…”

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confidence: 99%

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Use of trazodone as an adjunctive agent in the treatment of canine anxiety disorders: 56 cases (1995–2007)

Gruen¹,

Sherman²

2008

javma

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confidence: 99%

mentioning

confidence: 99%

Use of trazodone as an adjunctive agent in the treatment of canine anxiety disorders: 56 cases (1995–2007)

Gruen¹,

Sherman²

2008

javma

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“…It should be noted that, in a small number of dogs, minor vomiting was observed as a side effect of clomipramine supplementation. In order to look at the long-term effects of this medication, King et al (2004) contacted owners of 78 dogs from the original study. No cases of adverse effects were detected in dogs on clomipramine long term for more than 13 months.…”

Section: Clomipraminementioning

confidence: 99%

“…These include training the dog or instructing the owner on how to properly manage the condition with a variety of techniques (Voith and Borchelt 1996;Takeuchi et al 2000;Blackwell et al 2006;Blackwell et al 2016). Medications can also be administered, such as clomipramine (King et al 2004;Gaultier et al 2005;Cannas et al 2014) or fluoxetine (Simpson et al 2007;Karagiannis et al 2015). Treating separation anxiety will benefit both the dog and the relationship with its owner, as well as minimize the number of dogs surrendered to shelters (Thielke and Udell 2017).…”

Section: Introductionmentioning

confidence: 99%

Separation Anxiety in Canines and Potential Mitigation Options

Schlehahn

2018

USURJ

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Separation anxiety is a very common disorder that many domestic dogs suffer from. It comes second only to aggression in terms of behavioural disorders reported and is the most common anxiety disorder in dogs. Canine separation anxiety has a vast range of symptoms, including excessive vocalisation, destruction, inappropriate elimination, hypersalivation, and restlessness. Since these symptoms only occur in the absence of the owner and vary between dogs, separation anxiety is exceedingly difficult to diagnose. This disorder is potentially affected by numerous factors, including gender, breed, existing behavioural issues, the degree of attachment to the owner, and environmental factors, such as the source of the dog. Fortunately, options for anxiety mitigation exist, including proper training of the dog, as well as medications such as fluoxetine and clomipramine. It is imperative that a proper diagnosis and treatment is given to the dog early in the condition, as this disorder can negatively affect both the mental and physical health of the dog, as well as the owner-dog relationship. Unfortunately, the daily struggles of managing dogs with such a disorder take a toll on the owners. This potentially results in the all too common decision to surrender the dog to a shelter, and potentially euthanasia. Ultimately, this disorder still requires future research in many aspects, in order to better the lives of both the dog and its owners.

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“…Although these kinds of data (predominantly gained by questionnaires) should be used very cautiously as it is usually biased by the observational errors, opinions and emotions of the owners, nevertheless the observations of the dogs' closest human companions be not be underestimated. Questionnaire studies of dogs have usually been conducted when the studied phenomena (a) happen sporadically and mostly at home (for example events of dog-aggression: Hsu & Serpell 2003;Hsu & Sun 2010;attention deficit: Vas et al 2007; separation anxiety: King et al 2004); or (b) when the capacities under investigation can be mostly observed by the owners (for example dog-dog and dog-owner play patterns: Rooney et al 2000;and 'understanding' of human verbal utterances: Pongrácz et al 2001). In addition, this methodology shares a common ground with that applied in the case of children and their parents.…”

Section: Introductionmentioning

confidence: 99%

The owners’ assessment of “everyday dog memory”

Pongrácz

Benedek

Enz³

et al. 2012

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In a questionnaire study we surveyed the owners of 113 companion dogs. Owners had to mark on a four-grade scale how long their dog remembered particular memory items (persons, other animals, events, objects). Additionally we collected descriptive data on the demographical characteristics of the dog and the keeping conditions. A principal component analysis on the memory items resulted in five components. From these, two were connected to people ('Family' and 'Intruders'), three other components contained individual items of memory of objects and events ('Going out' , Playing' and 'Doing something'). Analyses of variance revealed that the dog-owner relationship, the keeping conditions, age and breed of the dog affect the dogs' memory as described by the owner. The amount of time spent together or the education of the owner had no or minimal effect on these components. Our study showed that owners form stable opinions about their dogs' episodic memory capacity. Nevertheless, the results can be biased by such factors that affect either the owners' opinions about their dog-companions, or the dogs' access to particular stimuli, which can modify the formation of memory traces. In the future, these results can serve as a starting point for empirical testing of family dogs' memory.

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Results of a follow-up investigation to a clinical trial testing the efficacy of clomipramine in the treatment of separation anxiety in dogs

Cited by 28 publications

References 10 publications

Use of trazodone as an adjunctive agent in the treatment of canine anxiety disorders: 56 cases (1995–2007)

Use of trazodone as an adjunctive agent in the treatment of canine anxiety disorders: 56 cases (1995–2007)

Separation Anxiety in Canines and Potential Mitigation Options

The owners’ assessment of “everyday dog memory”

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