Results of 1-year Diet and Exercise Interventions for ER+/PR+-/HER2- Breast Cancer Patients Correlated with Treatment Type

Abstract

RezumatScop: Multe paciente cu cancer mamar prezintă creştere ponderală pe parcursul administrării chimioterapiei sau al tratamentului antiestrogenic, ceea ce creşte riscurile de limfedem, metastază, recurenţă şi mortalitate de cauză general şi specific oncologică. Studiul de faţă îşi propune să evalueze eficienţa unei intervenţii nutriţionale şi kinetice în contracarearea obezităţii pacientelor cu cancer mamar. Pacienţi şi metodă: 165 paciente cu cancer mamar ER+/PR±/ HER2-aflate în tratament antiestrogenic au fost randomizate pentru a urma timp de 1 an, la domiciliu, fie o dietă bazată pe alimente natural bogate în proteine, calciu, probiotice şi prebiotice (D), fie dieta şi 4 minute de exerciţii fizice izometrice (D+Ex). Am măsurat greutatea (G), adipozitatea subcutanată (AS) şi adipozitatea viscerală (AV) cu un cântar cu impedanţă bioelectrică cu multifrecvenţe la 6 şi 12 luni şi am corelat rezultatele cu tipul de chimioterapie, intervenţie chirurgicală şi tratament antiestrogenic.

Food Intake During Cancer Therapy

“…4,44 In this review, a small number of studies suggested that higher caloric consumption was associated with better prognosis. 17,[26][27][28]30 Consumption of fat, protein, or fiber, as well as short-term fasting, had the suggestion of benefit, although outcomes were heterogeneous. 17,18,20,24,36 Feasibility of dietary changes was explored in a few studies.…”

“…17,[26][27][28]30 Consumption of fat, protein, or fiber, as well as short-term fasting, had the suggestion of benefit, although outcomes were heterogeneous. 17,18,20,24,36 Feasibility of dietary changes was explored in a few studies. Notably, patients short-term fasting feasible to implement and maintain.…”

“…Notably, patients short-term fasting feasible to implement and maintain. 17,18 After a cancer diagnosis and during treatment, patients often have a greater readiness to change, with increased motivation for improving overall health as patients work towards the best possible treatment outcomes. 45,46 In their study, Hoy et al specifically focused on the social cognitive theory of behavioral change to ensure greater uptake of the intervention.…”

“…Chemotherapy type did not affect the measured outcomes in the diet and exercise group, while the diet only group saw some differences between adjuvant and neoadjuvant, with patients not experiencing fat loss who underwent the additional chemotherapies. 17 Two studies focused on short-term fasting (STF) diets to determine the impact on treatment side effects. De Groot et al conducted a randomized controlled trial (RCT) of 13 women with breast cancer receiving neoadjuvant chemotherapy to assess the impact of STF on treatment side effects and hematologic parameters.…”

Body Composition in Women after Radical Mastectomy

“…Obesity, defined by WHO as a chronic disease, is a long-term inflammatory process [10]. As a result, excessive secretion of pro-inflammatory substances (TNF-α, IL-6, visfatin, resistin) occurs, while the concentration of anti-inflammatory substances (adiponectin, IL-1, IL-10) is reduced [11].…”