Results from the United States cohort of the HORIZON trial of a Schlemm canal microstent to reduce intraocular pressure in primary open-angle glaucoma

Jones, Jason J.; Koch, Douglas D.; McCabe, Cathleen M.; Rhee, Douglas J.; Lewis, Richard A.; Smith, Sophie Lloyd; Nguyen, Quang H.; Samuelson, Thomas W.; Walters, Tom; Marquis, Robert E.; Flowers, Brian; Vold, Steven D.; Foster, Gary; Greene, Brennan P.; Tran, Dan B.; Ansari, Husam; Olander, Kenneth W.; Atodaria, Neil; Qazi, Mujtaba A.; Meier, Edward; Godfrey, David G.; ElMallah, Mohammed K; Levine, Jason; Johnson, Cheyenne; Craven, E. Randy; Hawkins, Richard; Clifford, William S; Singh, Inder Paul; Chu, Y. Ralph; Crandall, Alan C.

doi:10.1016/j.jcrs.2019.03.024

Cited by 26 publications

(24 citation statements)

References 12 publications

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“…25 Several prospective studies have compared Hydrus with cataract surgery (phaco/Hydrus) to cataract surgery alone. 7,39,40 These studies show that phaco/Hydrus can significantly lower IOP 7.6-8.1 mmHg from baseline over 2-3 years. Additionally, each study supports a favorable outcome of phaco/Hydrus compared to cataract surgery alone.…”

Section: Hydrus ®mentioning

confidence: 70%

“…However, phaco/Hydrus eyes with or without a history of SLT still have statistically significant IOP reductions compared to cataract surgery alone. 39 Phaco/Hydrus and cataract surgery alone appear to have similar safety profiles. 7,39,40 The most common complications reported concerning the Hydrus Microstent are synechiae (6.8%-14.9%), uveitis or iritis (4.6%-5.6%), device obstruction (1.8%-5.4%), and hyphema (1.4%-1.6%).…”

Section: Hydrus ®mentioning

confidence: 93%

“…39 Phaco/Hydrus and cataract surgery alone appear to have similar safety profiles. 7,39,40 The most common complications reported concerning the Hydrus Microstent are synechiae (6.8%-14.9%), uveitis or iritis (4.6%-5.6%), device obstruction (1.8%-5.4%), and hyphema (1.4%-1.6%). Additionally, 0-4% of the patients required additional glaucoma surgery to control IOP.…”

Section: Hydrus ®mentioning

confidence: 93%

“…About 55.8%-78.5% of phaco/Hydrus eyes were also medication-free at 2-3 years versus 30.0%-39.2% that had cataract surgery alone (p < .001 and p = .02). 39,40 One prospective study also showed that Hydrus conferred an additional 2.3 mmHg reduction in IOP over cataract surgery and an additional reduction in medications of 0.4 (p < .001 for both variables). 7 When studying phaco/Hydrus versus cataract surgery alone, Jones et al observed significantly lower IOP reduction in both groups for patients who underwent SLT prior to the study compared to eyes without a history of SLT.…”

Section: Hydrus ®mentioning

confidence: 98%

“…Additionally, 0-4% of the patients required additional glaucoma surgery to control IOP. 7,39,40 Interestingly, phaco/Hydrus appeared to confer some protection against IOP spikes, defined as >10 mmHg above baseline IOP. Only 0.5%-0.9% of phaco/Hydrus eyes experienced an IOP spike, whereas 2.7% of eyes that underwent cataract surgery alone and 4.1% of eyes that underwent standalone Hydrus experienced an IOP spike when the various studies are examined.…”

Section: Hydrus ®mentioning

confidence: 99%

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Microinvasive Glaucoma Surgery: An Evidence-Based Review

Birnbaum

Neeson

Valle

2021

Seminars in Ophthalmology

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Purpose: Interest in micro-invasive glaucoma surgery (MIGS) has exploded over the last 8 years with an increase in MIGS procedures of at least 400% in the United States, according to Medicare data. MIGS is an umbrella term that can cover many different types of surgeries. This review focuses on peer-reviewed evidence for Trabectome ® , iStent inject ® , Kahook Dual Blade ® , XEN ® Gel Stent, and Hydrus ® . Methods: We present key recent studies evaluating the efficacy and safety of MIGS in various types of glaucoma patients with different stages of disease. Conclusion: We conclude that MIGS is generally safe and efficacious, although only some MIGS have been studied through randomized clinical trials. When comparing and contrasting the different MIGS procedures, large prospective studies are not yet the norm. High-quality large prospective studies involving MIGS will be an important next step as ophthalmologists decide how to incorporate MIGS into their surgical armamentarium.

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Section: Hydrus ®mentioning

confidence: 70%