Results from the Survey of Antibiotic Resistance (SOAR) 2014–16 in Ukraine and the Slovak Republic

Torumkuney, D; Pertseva, Tetyana; Bratus, E; Dziublik, A; Yachnyk, V; Líšková, Anna; Sopko, O N; Malynovska, K; Morrissey, Ian

doi:10.1093/jac/dky069

Cited by 10 publications

(8 citation statements)

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“…По данным международного исследования SOAR (2014-2016 гг. ), уровень чувствительности к пенициллину в Чехии составил 99,5% [9], в Греции -88,9% [10], в Болгарии -86,6% [11], в Словакии -54,2% [12], в Румынии -22,2% [11], доля чувствительных к пенициллину штаммов в России составила 67% [13].…”

Section: Discussionunclassified

Antimicrobial resistance of clinical Streptococcus pneumoniae isolates in Russia: the results of multicenter epidemiological study «PEHASus 2014–2017»

Иванчик¹,

Chagaryan²,

Сухорукова³

et al. 2019

CMAC

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Section: Discussionunclassified

Antimicrobial resistance of clinical Streptococcus pneumoniae isolates in Russia: the results of multicenter epidemiological study «PEHASus 2014–2017»

Иванчик¹,

Chagaryan²,

Сухорукова³

et al. 2019

CMAC

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“…Так, по данным международного исследования SOAR (2014-2016 гг. ), уровень чувствительности к ампициллину в Словакии составил 91,7%, в Украине -86,7%, в Греции -84,6%, в Румынии -81,8%, в России доля штаммов, чувствительных к ампициллину, составила 83,9% [7][8][9][10]. По данным международного исследования TEST (2015-2017 гг.…”

Section: Discussionunclassified

“…(Рисунок 2) свидетельствует о стабильной активности амоксициллина/клавуланата в отношении гемофильной палочки [12]. [7][8][9][10]. По результатам различных этапов исследования ПеГАС (2006-2017 гг.)…”

Section: Discussionunclassified

“…Так, по данным исследования SOAR (2014-2016 гг. ), уровень чувствительности к данным препаратам в Болгарии, Румынии, Сербии, Хорватии, Греции, Словакии и Украине составил 100%, в России -98,6% [7][8][9][10]. По данным исследования TEST (2015-2017 гг.…”

Section: Discussionunclassified

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Antimicrobial resistance of Haemophilus influenzae clinical isolates in Russia: the results of multicenter epidemiological study «PEHASus 2014–2017»

Иванчик

Сухорукова

Chagaryan

et al. 2019

CMAC

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Objective. To evaluate antimicrobial resistance patterns of clinical Haemophilus influenzae isolates from different regions of Russia during 2014–2017. Materials and Methods. We included in the study 185 clinical H. influenzae isolates from 13 Russian cities. Susceptibility testing was performed by reference broth microdilution method (ISO 207761:2006). Susceptibility testing results were interpreted using EUCAST v. 10.0 breakpoints. Results. H. influenzae isolates were highly susceptible to all (96.8%-100%) β-lactams tested (amoxicillin/ clavulanate, cefixime, ceftaroline, ceftibuten, cefditoren, ertapenem) with the exception of ampicillin (15.1% isolates were resistant). Fluoroquinolones, – ciprofloxacin, levofloxacin, moxifloxacin were active against 95.7%, 94.6% and 97.9% of isolates, respectively. Chloramphenicol was active against 97.9% of isolates, tetracycline – against 98.4% of isolates. Activity of trimethoprim/sulfamethoxazole was low (69.2% of susceptible isolates). Conclusions. In general, we can state the favorable situation with the susceptibility of H. influenzae to antimicrobials in Russia. However, the increasing of resistance to aminopenicillins and emerging of quinolone-resistant strains could become a problem in the future. Study Results are deposited at on-line resource AMRmap (http://AMRmap.ru).

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“…On the example of non-hospital respiratory infections agents Streptococcus pneumoniae and Haemophilus influenzae, territorial differences in the resistance level of the located isolates in the two neighbouring countries were found (Torumkuney et al, 2018). Overall, other studies on microorganism resistance to antibiotics, currently conducted in Ukraine, are narrowly specialized and do not encompass the problem in general.…”

Section: Introductionmentioning

confidence: 97%

Staphylococcus aureus and S. epidermidis in biological systems of hospital environment: Antibiotic resistance patterns in regions of Ukraine

Berezhna

Tertyshnyi²,

Makarova

et al. 2021

Regul. Mech. Biosyst.

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Staphylococcus bacteria are ubiquitous and often circulate in the biological systems of the hospital environment. Staphylococci have developed antibiotic resistance mechanisms resulting in a significant medical and economic burden to the healthcare system. The goal of our research was to conduct a comparative analysis of resistance to antibiotics in S. aureus and S. epidermidis isolates found in surgical hospitals in Kharkiv and Poltava regions. In 2013 through 2019, 151,015 and 98,754 tests were made by disc-diffusion method to identify the sensitivity in the S. aureus strains to antibiotics in Kharkiv and Poltava regions respectively. In 2013–2015, 15,589 tests were made in Kharkiv region to identify antibiotics sensitivity in S. epidermidis strains. Comparison of antibiotic resistance of the S. aureus strains in Kharkiv and Poltava regions was performed using the Pearson Chi-square test (χ2) and Fisher’s exact test. The proportion of S. aureus strains resistant to penicillins, cephalosporins, carbapenems, aminoglycosides, and macrolides was higher in Kharkiv region in terms of statistical validity than in Poltava region. Overall, the proportion of S. aureus strains resistant to lincozamids, tetracycline antibiotics, and fluoroquinolones in Poltava region was higher in terms of statistical validity than in Kharkiv region. An analysis of resistance of S. aureus strains to linezolid demonstrated that in Poltava region the proportion of resistant microorganisms was higher in terms of statistical validity in 2013–2014 and in 2016–2018. In Kharkiv region, in 2013 and in 2014, 96.3% and 89.1% of isolated strains of S. aureus respectively, were resistant to vancomycin. In 2019, more than a quarter of the located isolates (26.6%) in Poltava region were resistant to this antibiotic. The analysis of the dynamic of resistance in S. epidermidis isolates demonstrated that in 2015 nearly half of the isolates located in Kharkiv region were insensitive to penicillin antibiotics. Between 2013 and 2015, the spread of resistance to cephalosporins, aminoglycosides, macrolides, and fluoroquinolones among the S. epidermidis isolates noticeably increased. When S. epidermidis resistance to vancomycin was analyzed, a decrease in the proportion of resistant strains from 88.0% in 2013 to 8.7% in 2015 was noted. A promising direction for further research is the creation of passports of microorganism resistance in the regions and various health-care settings, as well as the creation of a unified national database network on microorganism resistance using modern methodologies for determining the phenotypes and genotypes of microorganisms.

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Results from the Survey of Antibiotic Resistance (SOAR) 2014–16 in Ukraine and the Slovak Republic

Cited by 10 publications

References 10 publications

Antimicrobial resistance of clinical Streptococcus pneumoniae isolates in Russia: the results of multicenter epidemiological study «PEHASus 2014–2017»

Antimicrobial resistance of clinical Streptococcus pneumoniae isolates in Russia: the results of multicenter epidemiological study «PEHASus 2014–2017»

Antimicrobial resistance of Haemophilus influenzae clinical isolates in Russia: the results of multicenter epidemiological study «PEHASus 2014–2017»

Staphylococcus aureus and S. epidermidis in biological systems of hospital environment: Antibiotic resistance patterns in regions of Ukraine

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