Results Following Surgical Resection of Recurrent Chordoma Of the Spine: Experience in a Single Institution

Abstract

Background: Chordoma of the spine is a low-grade malignant tumor with vague and indolentsymptoms thus large tumor mass is encountered at the time of diagnosis in almost cases and makes a difficult for En-bloc free-margin resection. Salvage therapyfor recurrent chordoma is very challenging due to its relentless nature and refractory to adjuvant therapies. The aim of this present study was to report the oncologic outcome following surgical resection of chordoma of the spine.Materials and Methods:Retrospective review of 10 consecutive cases of recurrent chordoma patients who underwent surgical treatment between 2003 and 2018atone tertiary-care center was conducted.Results: There were 10 patients, 4 females and 6 males were included in this study. Eight patients had local recurrence. The recurrence was encountered at the muscle, surrounding soft tissue and remaining bony structure. Distant metastaseswere found in 2 patients. The average time of recurrence was 28 months after first surgery. Conclusion:En-bloc free margin resection is mandatory toprevent recurrent. The clinical vigilance and investigation to identify tumor recurrent should be obtained periodically,in the first 28 months. Detection of recurrent in early stage with a small mass may be the best chance to perform an En-Bloc margin free resection to prevent further recurrent.

Outcomes of Recurrent Mobile Spine Chordomas

“…3,5–17 These studies demonstrated poor overall local recurrence-free survival and overall survival, but en bloc and gross total excision tend to improve survival rates. 3,4,6,17,18…”

“…3,[5][6][7][8][9][10][11][12][13][14][15][16][17] These studies demonstrated poor overall local recurrence-free survival and overall survival, but en bloc and gross total excision tend to improve survival rates. 3,4,6,17,18 Our group previously reported the outcomes of a focused series of primary mobile spine chordomas treated surgically. 19 This study demonstrated the…”

“…Given the relative scarcity of these tumors, most of the previous literature has combined primary and recurrent chordomas into a single cohort and included chordomas in all locations. 3,[5][6][7][8][9][10][11][12][13][14][15][16][17] These studies demonstrated poor overall local recurrence-free survival and overall survival, but en bloc and gross total excision tend to improve survival rates. 3,4,6,17,18 Our group previously reported the outcomes of a focused series of primary mobile spine chordomas treated surgically.…”