Results and Views of Women in Population-Wide Pregnancy Screening for Trisomy 21 in East Finland

Heikkilä, Annaleena; Kirkinen, Pertti; Saarikoski, Seppo

doi:10.1159/000264439

Cited by 10 publications

(11 citation statements)

References 15 publications

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“…[49][50][51][52][53][54][55][56][57][58][59][60][61][62][63][64][65] The main research question of these studies varied, with few aiming to ascertain whether or not participants had received sufficient information prior to the offer of testing (Appendix 3 describes the research aims of included studies).…”

Section: Structure Of This Reportmentioning

confidence: 99%

“…A ll 52 studies included in this section referred to a measure that aimed to understand women's prenatal testing choices; 34 were concerned with Down's syndrome screening, 17,45,48,[51][52][53][54][55][57][58][59][60][61][62][63][64][65]75,[81][82][83][84]86,[112][113][114][115][116][117][118][119][120][121][122] and 18 with prenatal carrier testing. 89,90,92,94,[96][97][98][99][100][101][102][103][104]107,[123]…”

Section: Part Two: Other Antenatal Genetic Screening Programmesmentioning

confidence: 99%

“…Twenty-one studies elicited women's views on the value of prenatal screening, 12 for chromosomal disorders 52,53,55,57,59,60,64,113,114,117,119,121 and nine for carrier testing. 80,90,92,94,96,98,102,124,125 About 80% of women preferred to have the screening option to just the diagnostic test alternative 64,119 and would consider paying for these services.…”

Section: Do Women Want Prenatal Testing?mentioning

confidence: 99%

“…80,90,92,94,96,98,102,124,125 About 80% of women preferred to have the screening option to just the diagnostic test alternative 64,119 and would consider paying for these services. 55,104,119 Further, about 60-75% of women stated they valued prenatal testing, 52,53,59,89,92,94,96,98,113,114,117,121,124 felt it empowered and enabled women to make informed choices 57,114 and perceived it as a maternal responsibility to ensure the health of the baby. 57,114 A smaller percentage of women (about 10%) stated that prenatal testing medicalises pregnancy, 53 generates worry, 53,90,122,125 creates a false sense of control 53 and may lead to increased…”

Section: Do Women Want Prenatal Testing?mentioning

confidence: 99%

“…51,89,115,117 A minority (8%) referred to a lack of resources, such as child care and time, as reasons for not having testing. 104,117 The 'predictor studies' assessed the following cognitions of women choosing to have or not have testing: attitudes towards the abnormality; 17,53,57,61,80,94,96,97,103,107,112,123 perceptions of risk of having a healthy baby or baby with an abnormality; 17,51,57,[60][61][62]65,74,80,86,89,92,94,96,97,103,107,123,124 52,58,61,65,80,92,94,100,[115][116][117]…”

Section: Do We Know Why Women Choose To Have or Not Have Testing?mentioning

confidence: 99%

See 4 more Smart Citations

Psychosocial aspects of genetic screening of pregnant women and newborns: a systematic review

Green

Hewison²,

Bekker³

et al. 2004

Health Technol Assess

261

254

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Section: Structure Of This Reportmentioning

confidence: 99%

Section: Part Two: Other Antenatal Genetic Screening Programmesmentioning

confidence: 99%

Section: Do Women Want Prenatal Testing?mentioning

confidence: 99%

Section: Do Women Want Prenatal Testing?mentioning

confidence: 99%

Section: Do We Know Why Women Choose To Have or Not Have Testing?mentioning

confidence: 99%

See 3 more Smart Citations

Psychosocial aspects of genetic screening of pregnant women and newborns: a systematic review

Green

Hewison²,

Bekker³

et al. 2004

Health Technol Assess

261

254

View full text Add to dashboard Cite

show abstract

Second trimester serum tests for Down's Syndrome screening

Alldred

Deeks

Guo

et al. 2012

Cochrane Database of Systematic Reviews

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Background Down's syndrome occurs when a person has three copies of chromosome 21-or the specific area of chromosome 21 implicated in causing Down's syndrome-rather than two. It is the commonest congenital cause of mental retardation. Noninvasive screening based on biochemical analysis of maternal serum or urine, or fetal ultrasound measurements, allows estimates of the risk of a pregnancy being a ected and provides information to guide decisions about definitive testing. Objectives To estimate and compare the accuracy of second trimester serum markers for the detection of Down's syndrome.

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First trimester serum tests for Down's syndrome screening

Alldred

Takwoingi

Guo

et al. 2015

Cochrane Database of Systematic Reviews

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Tests involving two markers in combination with maternal age, specifically PAPP-A, free βhCG and maternal age are significantly better than those involving single markers with and without age. They detect seven out of 10 Down's affected pregnancies for a fixed 5% FPR. The addition of further markers (triple tests) has not been shown to be statistically superior; the studies included are small with limited power to detect a difference.The screening blood tests themselves have no adverse effects for the woman, over and above the risks of a routine blood test. However some women who have a 'high risk' screening test result, and are given amniocentesis or chorionic villus sampling (CVS) have a risk of miscarrying a baby unaffected by Down's. Parents will need to weigh up this risk when deciding whether or not to have an amniocentesis or CVS following a 'high risk' screening test result.

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Results and Views of Women in Population-Wide Pregnancy Screening for Trisomy 21 in East Finland

Cited by 10 publications

References 15 publications

Psychosocial aspects of genetic screening of pregnant women and newborns: a systematic review

Psychosocial aspects of genetic screening of pregnant women and newborns: a systematic review

Second trimester serum tests for Down's Syndrome screening

First trimester serum tests for Down's syndrome screening

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