Results and conclusions of the national toxicology program's rodent carcinogenicity studies with sodium fluoride

Bucher, John R.; Hejtmancik, Milton R.; Toft, Jason D.; Persing, Ronald L.; Eustis, Scot L.; Haseman, Joseph K.

doi:10.1002/ijc.2910480517

Cited by 42 publications

(24 citation statements)

References 22 publications

(15 reference statements)

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“…We did not observe any lesions in the glandular or nonglandular portions of stomach such as observed by others in rodents in fluorosis (7,32).…”

Section: The Microscopic Lesionssupporting

confidence: 70%

“…Similarly, in the 2-yr NaF carcinogenicity study of the NTP (7), osteosclerosis was noted in the high-dose female rats only and no bone lesions in the male rats and male or female mice. Whereas in rodent experiments (7,32) the exposure period was 2 yr, in cattle experiments (43,44) the exposure period was several years. In our experiments, the maximum exposure period is estimated to be 3-4 mo before the rats were sacrificed.…”

Section: The Microscopic Lesionsmentioning

confidence: 99%

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Fluorosis in a Wild Cotton Rat (Sigmodon hispidus) Population Inhabiting a Petrochemical Waste Site

Paranjpe

Chandra

Qualls³

et al. 1994

Toxicol Pathol

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We have developed an in situ mammalian model for evaluating environmental contamination using wild cotton rats. In a series of experiments, 200 male cotton rats were captured during 4 collection periods (spring 1991 = 35; fall 1991 = 60; spring 1992 = 53; fall 1992 = 52). A total of 103 of these cotton rats were captured from control sites, and the remaining 97 were captured from an abandoned oil refinery. All sites were located in the vicinity of Cyril, Oklahoma. There were alterations in the incisors of cotton rats captured from the refinery site. Normal color of cotton rat incisors is deep yellow-orange, which is imparted by a pigment normally produced by ameloblasts. Grossly, the upper incisors of 37 of 97 rats and lower incisors of 54 of 97 rats were affected. The affected incisors were white, chalky, and thin with striations and erosions of the enamel. Microscopic examination revealed that there were dysplastic and necrotic changes in the ameloblasts. The bone fluoride levels were significantly higher in rats captured from the refinery as compared to the rats captured from the control sites.

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“…We did not observe any lesions in the glandular or nonglandular portions of stomach such as observed by others in rodents in fluorosis (7,32).…”

Section: The Microscopic Lesionssupporting

confidence: 70%

Section: The Microscopic Lesionsmentioning

confidence: 99%

Fluorosis in a Wild Cotton Rat (Sigmodon hispidus) Population Inhabiting a Petrochemical Waste Site

Paranjpe

Chandra

Qualls³

et al. 1994

Toxicol Pathol

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“…Fluorides have been administered in drinking water to mice and rats in an NTP bioassay. There was equivocal evidence of carcinogenic activity of sodium¯uoride in male rats based on the occurrence of a small number of osteosarcomas in treated animals [Bucher et al, 1991]. There is no suggestion that¯uoride in the drinking water is linked with elevated risk of cancer [Cantor, 1997].…”

Section: Discussionmentioning

confidence: 99%

Lung cancer case-control study of beryllium workers

et al. 2001

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Background Cohort mortality studies have found elevated lung cancer mortality among beryllium‐exposed workers, but none evaluated the association between beryllium exposure level and lung cancer risk. A nested case–control study of lung cancer within a beryllium processing plant was conducted to investigate the relationship between level of beryllium exposure and lung cancer. Methods Lung cancer cases were identified by mortality follow‐up through 1992 of a cohort of male workers at a beryllium alloy production plant. Each of 142 lung cancer cases was age–race‐matched to five controls. Calendar‐time‐specific beryllium exposure estimates were made for every job in the plant and were used to estimate workers' cumulative, average, and maximum exposures. The potential confounding effects of smoking were also evaluated. Results Lung cancer cases had shorter tenures and lower lifetime cumulative beryllium exposures than controls, but higher average and maximum exposures. However, after applying a 10‐ and 20‐year lag, exposure metrics were higher for cases. Odds ratios in analyses lagged 20 years were significantly elevated for those with higher exposure compared to the lowest exposure category. Significant positive trends were seen with the log of the exposure metrics. Smoking did not appear to confound exposure–response analyses. Conclusions Increased lung cancer among workers with higher lagged beryllium exposures and lack of evidence for confounding by cigarette smoking, provide further evidence that beryllium is a human lung carcinogen. Am. J. Ind. Med. 39:133–144, 2001. Published 2001 Wiley‐Liss, Inc.

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“…Several animal studies have been conducted, but only one found evidence that fluoride exposure may increase osteosarcoma formation, specifically in male rats [14]. Human studies also show conflicting results.…”

Section: Introductionmentioning

confidence: 97%

Age-specific Fluoride Exposure in Drinking Water and Osteosarcoma (United States)

Bassin

Wypij

Davis

et al. 2006

Cancer Causes Control

215

102

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Results and conclusions of the national toxicology program's rodent carcinogenicity studies with sodium fluoride

Cited by 42 publications

References 22 publications

Fluorosis in a Wild Cotton Rat (Sigmodon hispidus) Population Inhabiting a Petrochemical Waste Site

Fluorosis in a Wild Cotton Rat (Sigmodon hispidus) Population Inhabiting a Petrochemical Waste Site

Lung cancer case-control study of beryllium workers

Age-specific Fluoride Exposure in Drinking Water and Osteosarcoma (United States)

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