Results and complications of operative staging in cervical cancer: Experience of the Gynecologic Oncology Group

Lagasse, Leo D.; Creasman, William T.; Shingleton, Hugh M.; Ford, John H.; Blessing, John A.

doi:10.1016/0090-8258(80)90013-x

Cited by 304 publications

(117 citation statements)

References 9 publications

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“…The high percentage of false-negative results was attributed to microscopic neoplastic foci in pelvic and paraaortic lymph nodes that did not become opaque. 28,41,42 …”

Section: Lymphangiographymentioning

confidence: 99%

Imaging in cervical cancer

Follen

Levenback

Iyer

et al. 2003

Cancer

125

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“…The high percentage of false-negative results was attributed to microscopic neoplastic foci in pelvic and paraaortic lymph nodes that did not become opaque. 28,41,42 …”

Section: Lymphangiographymentioning

confidence: 99%

Imaging in cervical cancer

Follen

Levenback

Iyer

et al. 2003

Cancer

125

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“…La estadificación clínica mostró que la mayoría de nuestras pacientes presentaban un cáncer de cérvix localmente avanzado, siendo el estadio IIB el más frecuente con un 33,6 % de los casos; el uso de esta clasificación es cuestionado por diversos estudios que la consideran poco precisa para definir la extensión de la enfermedad (16).…”

Section: Discussionunclassified

Características clínicas y pronóstico de las pacientes con cáncer de cérvix tratadas en tres instituciones de salud en Barranquilla, Colombia, de 2005 a 2011

Fernández-Mercado

Amaya-Guío

González-Rubio

et al. 2014

Rev. Colomb. Obstet. Ginecol.

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Objetivo: describir las características clínicas y el pronóstico de las pacientes con cáncer de cérvix tratadas en tres instituciones de salud en Barranquilla, Colombia.Materiales y métodos: estudio de cohorte retrospectiva descriptiva. Se revisaron las bases de datos de las tres instituciones participantes en donde se identificaron los casos que tuvieron diagnóstico CIE 10 de: tumor maligno de endocérvix, tumor maligno de exocérvix, tumor maligno del cuello del útero y tumor maligno del itsmo uterino. Se excluyeron pacientes remitidas por recidiva tumoral. En caso de deceso, este fue corroborado con el certificado de defunción. Se describe la mortalidad absoluta por estadio clínico. Para establecer el pronóstico se estimó la probabilidad de estar libre de enfermedad y de sobrevivir al primer, tercer y quinto año de seguimiento.Resultados: se identificaron 375 pacientes con diagnóstico de carcinoma de cérvix, de las cuales 27 se perdieron en el seguimiento para un total de 348 pacientes evaluadas. Se encontró una tasa de complicaciones cercana al 19% siendo más frecuentes en pacientes con radioterapia (94%) que en las que recibieron tratamiento quirúrgico (6%). La probabilidad de sobrevida a los 5 años es del 92% y la probabilidad de estar libre de enfermedad a los 5 años es del 89%.Conclusiones: los resultados obtenidos en cuanto a complicaciones y sobrevida posterior al tratamiento fueron similares a lo reportado en la literatura. Se requieren más estudios con una mayor profundidad metodológica que caractericen el pronóstico de las pacientes con cáncer de cérvix en nuestra población.

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“…The 1980 report by the Gynecologic Oncology Group (GOG), which reviewed data for 545 patients with surgically staged cervical cancer, found errors in the FIGO system in 53.4% of patients with stage IIB disease and in 49.2% of patients with stage IIIB disease [12]. As the American College of Radiology Imaging Network (ACRIN )6651/GOG 183 Intergroup study showed [5], current MRI technology delineates tumour boundaries accurately and is frequently used to guide both treatment development and application [3,4].…”

Section: Discussionmentioning

confidence: 99%

Prognostic significance of MRI-detected bladder muscle and/or serosal invasion in patients with cervical cancer treated with radiotherapy

Nam

Huh²,

Park³

et al. 2010

British Journal of Radiology

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ABSTRACT. In cervical cancer, the prognostic significance of bladder wall invasion on MRI without pathological evidence of mucosal invasion is not known. From 454 consecutive patients with cervical cancer who were treated with radiation, we reviewed images and analysed the outcome of 92 patients with the Federation of International Gynecology and Obstetrics (FIGO) stage IIIB-IVA. We analysed the patients in three groups, normal, wall (muscle and/or serosal) invasion and mucosal invasion, according to the findings on the MRI. Kaplan-Meier life table analysis and the log-rank test were used to assess the survival rates and differences according to prognostic factors. MRI detected abnormalities in the bladder wall in 42 patients (45.6%): wall invasion in 24 and mucosal invasion in 18. 5 of 18 patients, suspected on MRI to have mucosal invasion, showed no pathological evidence of mucosal invasion. Median follow-up period was 34 months. 3-year cause-specific survival (CSS) in the normal group compared with the wall invasion group was 76.2% vs 71.4% (p50.48). 3-year CSS for the wall invasion group compared with the mucosal invasion group was 71.4% vs 54.3% (p50.04). Mucosal invasion on MRI (p50.03) and concurrent chemoradiotherapy (p50.01) was significant for CSS. The prognosis for patients with cervical cancer with evidence of muscle and/or serosal invasion of the bladder on MRI may not differ from that for patients without abnormality on MRI. In patients with the MRI finding of bladder mucosal invasion, further studies should be conducted regarding the role of cystoscopy to determine the need for pathological confirmation.

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Results and complications of operative staging in cervical cancer: Experience of the Gynecologic Oncology Group

Cited by 304 publications

References 9 publications

Imaging in cervical cancer

Imaging in cervical cancer

Características clínicas y pronóstico de las pacientes con cáncer de cérvix tratadas en tres instituciones de salud en Barranquilla, Colombia, de 2005 a 2011

Prognostic significance of MRI-detected bladder muscle and/or serosal invasion in patients with cervical cancer treated with radiotherapy

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