Results after Surgery in Stage-I Bronchogenic Carcinoma

Wertzel, H; Siebert, H.; Lange, W.; Swoboda, L; Graf, Emma; Hasse, J

doi:10.1055/s-2007-1010255

Cited by 24 publications

(10 citation statements)

References 5 publications

(5 reference statements)

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“…The risk from pulmonary resection is dependent on the extent of resection. In that way, it is important to point out that the proportion of patients having undergone a pneumonectomy was about 13% in the present series, a rate that is in accordance with what is usually reported in this early stage, ranging from 5 to 20% [6,7,[17][18][19][20]. Of concern is the fact that the technique of lymph node sampling did not influence postoperative mortality or major morbidity accordingly to previous claims [5,7], but in contrast with others [1].…”

Section: Discussionsupporting

confidence: 89%

Does the extent of lymph node dissection influence outcome in patients with stage I non-small-cell lung cancer?

Doddoli¹,

Aragon²,

Barlési³

et al. 2005

European Journal of Cardio-Thoracic Surgery

132

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Section: Discussionsupporting

confidence: 89%

Does the extent of lymph node dissection influence outcome in patients with stage I non-small-cell lung cancer?

Doddoli¹,

Aragon²,

Barlési³

et al. 2005

European Journal of Cardio-Thoracic Surgery

132

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“…Tumor stage, performance status and weight loss at the time of diagnosis have been found tohave a negative impact on patient survival from NSCLC in previous research [34,35]. The present study confirmed that advanced cancer stage and poor performance status were prognostic factors for NSCLC survival.…”

Section: Discussionsupporting

confidence: 88%

Clinical Biomarkers and Prognosis in Taiwanese Patients with Non-Small Cell Lung Cancer (NSCLC)

Li¹,

Chen²,

Chang³

et al. 2012

JCT

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Introduction: Lung cancer is the leading cause of cancer death worldwide with poor survival rates. However, the prognostic factors for survival of patients with lung cancer are not well-established. In this study, we examined the impact of routine laboratory biomarkers and traditional factors on survival of patients with non-small cell lung cancer (NSCLC). Method: Secondary data analysis was conducted from a retrospective study of 404 patients with newly diag-nosed lung cancer in 2005-2007 in Taiwan. There were eight routine laboratory biomarkers and eight traditional factors investigated in the analyses. Cox proportional hazards model was used to assess the hazard ratios for the association between risk factors and patient overall survival. The Kaplan-Meier method was used to compare survival curves for each prognostic indicator. Results: High WBC counts (HR = 1.798, 95%CI: 1.225 - 2.639), low Hgb level (HR = 1.437, 95%CI: 1.085 - 1.903), and low serum albumin level (HR = 2.049, 95%CI: 1.376 - 3.052) were significant laboratory prognostic biomarkers for poor NSCLC survival. Additionally we confirmed the traditional prognostic factors for poor overall survival among NSCLC patients, including older age, comorbidity conditions, advanced cancer stage, and non-surgical treatment. Conclusions: This study identified three available laboratory biomarkers, high WBC counts, low Hgb level, and low serum albumin level, to be significant prognostic factors for poorer overall survival in NSCLC patients. Further prognostic evaluation studies are warranted to compare different ethnic groups on the prognostic values of these clinical parameters in NSCLC survival outcomes. These identified prognostic biomarkers should be included in early risk screening of hospitalized lung cancer patient population

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“…20 Many but not all studies of positive margins of surgically treated lung cancers have shown adverse impact by residual disease. [1][2][3][4][5][6][7][8][9][10][11][12][13][14][15][16] Microscopic residual tumor at the bronchial resection margin has then been divided into different patterns. Cotton 1 first divided microscopic residual disease into mucosal tumor (spreading from a mucosal lesion), and extramucosal microscopic residual disease (tumor involving peribronchial soft tissues or tumor within lymphatics).…”

Section: Discussionmentioning

confidence: 99%

“…To this end, resection margins should be uninvolved with tumor. Many surgical series have demonstrated adverse patient outcome with either microscopic or macroscopic residual tumor at the bronchial resection margin, [1][2][3][4][5][6][7][8][9][10][11][12][13] and thus it is usually assumed that negative margins give the best chance for local control. However, poor outcomes with residual microscopic disease have not been reported by all authors.…”

mentioning

confidence: 99%

Bronchial margins in lung cancer resection specimens: utility of frozen section and gross evaluation

2004

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Pathology reports for all lobectomy and pneumonectomy specimens at UNC Hospitals between 1991 and 2000 (n ¼ 405) were reviewed for correlation between frozen section and final bronchial margin, gross distance between tumor and margin and tumor type. Frozen section was performed in 268 cases (66%). A total of 243 were true negatives (90.6 %), 16 (6.0%) were true positives, four (1.5%) were false positives and five (1.9%) were false negatives. The site of tumor in true-positive cases was mucosal (11), submucosal (three), lymphatics (one), peribronchial (one). The site of tumor in false-negative cases was submucosal (two), lymphatics (one), peribronchial (two). In 137 cases, no bronchial frozen section was performed; there was one case (0.7%) with positive margin. There was no correlation between final margin positivity and distance between gross tumor and margin. Tumor distance to margin in positive margin cases varied from grossly involved to 3 cm away. There were 72 cases in which wedge resection was performed before lobectomy in which no gross tumor remained in the lobectomy, and in all cases final bronchial margins were negative. In all, 373 of cases (92%) were nonsmall carcinomas. Of these, 10 (2.7%) had positive margins. Tumors other than nonsmall cell carcinoma accounted for a disproportionate number of positive margins. In all, 3/6 of adenoid cystic/ mucoepidermoid carcinoma, 1/7 small cell carcinoma and 1/1 lymphoma cases had positive margins. In conclusion, frozen section evaluation of bronchial margins is helpful in central lung tumors. Mucosal tumor is preferentially identified in frozen section. Gross evaluation of margins is problematic, as intramucosal carcinoma or tumor in lymphatics may not be detected, but 3 cm was a 'safe' distance for gross tumor from margin. In lobectomies following wedge resection in which no gross tumor remained, all had negative margins. Salivary gland-type tumors have a high incidence of positive margins, and frozen section is particularly indicated in these tumors.

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Results after Surgery in Stage-I Bronchogenic Carcinoma

Cited by 24 publications

References 5 publications

Does the extent of lymph node dissection influence outcome in patients with stage I non-small-cell lung cancer?

Does the extent of lymph node dissection influence outcome in patients with stage I non-small-cell lung cancer?

Clinical Biomarkers and Prognosis in Taiwanese Patients with Non-Small Cell Lung Cancer (NSCLC)

Bronchial margins in lung cancer resection specimens: utility of frozen section and gross evaluation

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