Results after pancreatic resection for metastatic lesions

Hiotis, Spiros P.; Klimstra, David S.; Conlon, Kevin C.; Brennan, Murray F.

doi:10.1007/bf02574484

Cited by 178 publications

(146 citation statements)

References 15 publications

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“…74 In a review of a number of patients with metastatic lesions to the pancreas, melanoma accounted for 2.5% to 15% of all cases. 4,6,[8][9][10]64,75 There are only limited data specific to the resection of malignant melanoma to the pancreas. In a retrospective review by Wood et al of 60 patients with melanoma metastatic to solid intra-abdominal organs, 44 patients underwent complete resection of disease in single or multiple organ sites.…”

Section: Malignant Melanomamentioning

confidence: 99%

Metastatic Disease to the Pancreas and Spleen

Showalter

Hager

Yeo

2008

Seminars in Oncology

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Section: Malignant Melanomamentioning

confidence: 99%

Metastatic Disease to the Pancreas and Spleen

Showalter

Hager

Yeo

2008

Seminars in Oncology

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“…According to Hiotis' publication, 69% of patients were asymptomatic when metastases developed only within the pancreas. [4] Therefore, these metastases can only be detected on follow-up examinations performed due to clinical symptoms, "accidentally" during the treatment of the primary tumor, or on regular regular follow-ups. In most of the cases, an exact diagnosis is proved on the histopathological examination after surgery or autopsy.…”

Section: Discussionmentioning

confidence: 99%

Secondary tumors of the pancreas: four cases and literature review

Puskás

Henits

Kovács

2015

JBGC

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Four cases affected by pancreatic metastases revealed by CT and MR during the last two years are presented. In Case 1 and 2 the metastatic disease appeared more than 10 years after the primary renal neoplasm was diagnosed. In the remaining two cases -non small cell lung cancer and non-Hodgkin disease -the metastases developed shortly after the onset of the primary malignancy. A literature review is given. Metastases in the pancreas are rare. The symptoms and imaging features are variable, therefore non-invasive imaging diagnosis is difficult. To resolve this problem a thorough scrutiny of the patients' medical history, and the functional imaging methods can be helpful.

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“…The pancreas is a favoured site for isolated metastases from renal cell carcinoma [4,7]. Pancreatic resection for these patients may improve survival and may be curative [4,7].…”

Section: Discussionmentioning

confidence: 99%

“…Potential survival bene®ts of pancreatic resection in selected patients, especially those with metastases from renal cell carcinoma, are established [4,5]. However, experience with pancreatic resection for metastatic melanoma is limited and controversial.…”

Section: Introductionmentioning

confidence: 99%

Pancreatic resection for metastatic melanoma

Nikfarjam¹,

Evans²,

Christophi³

2003

HPB: Official Journal of The International Hepato Pancreato Bil

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BackgroundThe pancreas is an occasional site of metastases from melanoma. It may be the only location of metastatic disease, but more often the melanoma metastasises to other organs as well. Treatment options are somewhat limited, and the role of operative treatment is poorly de®ned. Case outlinesTwo patients presenting with abdominal pain were found to have pancreatic lesions. A 45-year-old woman had a pyloruspreserving pancreatoduodenectomy for a mass in the head of pancreas; concurrent liver nodules were treated by segmental liver resection. A 55-year-old man had a total pancreatectomy for multiple pancreatic tumours. Both patients gave a history of ocular melanoma, diagnosed >10 years previously. They had no evidence of malignancy elsewhere. Histology of resected specimens con®rmed metastatic melanoma with features consistent with an ocular primary. All resection margins were clear of malignancy, and no lymph node metastases were detected. At 6 months follow-up there were no signs of tumour recurrence. DiscussionComplete surgical resection offers potential cure in selected patients with metastatic melanoma involving the pancreas, when there is no evidence of widespread disease.

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Results after pancreatic resection for metastatic lesions

Abstract: Long-term survival after pancreatic resection for metastatic disease is achievable, and patients with primary renal cell carcinoma seem to have a more favorable prognosis. Surgical resection should thus be offered to selected patients with isolated metastatic disease to the pancreas.

Cited by 178 publications

References 15 publications

Metastatic Disease to the Pancreas and Spleen

Metastatic Disease to the Pancreas and Spleen

Secondary tumors of the pancreas: four cases and literature review

Pancreatic resection for metastatic melanoma

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