Résultats des tests nationaux d'évaluation (scolarité primaire) de CE2 et de 6e chez 73 élèves hypothyroïdiens congénitaux dépistés à la naissance

Transient Hypothyroidism at 3-Year Follow-Up among Cases of Congenital Hypothyroidism Detected by Newborn Screening

“…This finding could indicate the presence of an important public health problem, inasmuch as poor treatment compliance is a predictor of adverse neurodevelopmental outcomes in congenital hypothyroidism. 9,16–18 In addition, although clinicians frequently reported normal thyroid function in children who stopped taking their medication without medical supervision, confirmation of this by laboratory testing was rarely available. Because we were unable to follow up 44% of our cohort, the burden of unsupervised treatment cessation in congenital hypothyroidism that we uncovered is may be an underestimate of the magnitude of the problem.…”

“…5,6 Pathologically low concentrations of thyroid hormone experienced during critical stages of development may cause severe mental retardation and skeletal growth abnormalities. 5,7–15 The deleterious outcomes of untreated congenital hypothyroidism are well known 9,16–18 ; however, recent evidence suggests that many diagnosed children are no longer treated after age 3 years.…”

Influence of severity of congenital hypothyroidism and adequacy of treatment on school achievement in young adolescents: a population-based cohort study

“…These studies investigating children of at least 5 y of age have yielded con icting results. Some of them did not nd any difference in cognitive (4,5,14,17,26) or school performance (27,28) in comparison with controls, whereas others reported minor de cits (2,6,7,16,18,19). One recent report demonstrated a mild delay in learning abilities in patients evaluated at 8.8 y of age, with catchup at a subsequent evaluation 3 y later (20).…”

“…Nevertheless, in our study, age at start of treatment in patients identi ed by the newborn screening program and treated before 40 d of life was apparently unrelated to subsequent school achievement. Although some studies have shown that an earlier onset of treatment in newborn CH patients is correlated with better subsequent intellectual development (4,7,10,18), in most reports age at start of treatment in patients identi ed by the newborn screening does not seem to be an important factor in the overall risk of subsequent poor intellectual development (3,5,16,20,28). However, in most countries treatment is now started earlier than was the case at the start of the screening era, usually being initiated within the rst 2 wk of life (31).…”

“…However, studies of intelligence and cognitive development of CH children have often been limited to small numbers of patients and have not always thoroughly controlled for environmental and socioeconomic factors that may in uence test results. Long-term treatment outcome has still not been completely evaluated (14)(15)(16)(17)(18)(19)(20).…”