Résultats de la prise en charge endoscopique de l'ulcère gastroduodénal hémorragique: une série de 125 patients

Jemni, I.; Mohamed, HL; Aissaoui, F; Amor, Sana Ben; Zakhama, M.; Guediche, A.; Bouhlel, W.; Mansour, W. Ben; Nabil, BC; Safer, L.

doi:10.1055/s-0039-1680924

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“…For instance, the risk of developing upper and lower gastroduodenal bleeding is high in patients treated with ASA, in the prevention or in the treatment of ischemic cardiovascular diseases [16, 17]. Although the treatment of HP infections has improved significantly in recent years due to the development of the antibiotic pharmaceutical industry, the prevalence of peptic ulcer morbidity has not decreased accordingly and mortality from such a pathology (2.5% to 5.8%) still remains a public health concern [18]. Conventional treatments for peptic ulcers are based on one hand on the reduction of factors that induce gastric mucosal damage, such as proton pump inhibitors (IPPs), anticholinergics, histaminic H 2 -receptor antagonists, and antacids, and on the other hand on the improvement of the protective mucosal layer by mucus production or by synthetic mucus mimetic drugs [6, 19, 20].…”

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confidence: 99%

Effectiveness ofOpuntia ficus indicaL.inermisSeed Oil in the Protection and the Healing of Experimentally Induced Gastric Mucosa Ulcer

Khémiri

Bitri

2019

Oxidative Medicine and Cellular Longevity

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Gastric ulcer is a painful lesion of the gastric mucosa which can be disabling, or even more very serious in the case of a perforation of the stomach and internal hemorrhage. Traditional pharmacopeias have shown the efficacy of various plant extracts in the treatment of this pathology. Some extracts from Opuntia ficus indica (OFI) have been proven to have medicinal therapeutic benefits. The aim of this study was to investigate the preventive and curative effects of OFI seed oil extracted by cold pressing on an ethanol-induced gastric ulcer model in rats. Gastroprotective activities of the oil were assessed as pretreatments prior to ethanol gavage of Wistar rats compared to reference drugs. Two oil dose effects were tested. Ulcer and gastric parameters were measured (ulcerated areas (mm2), % of ulcer inhibition, gastric juice volume and pH, and mucus weight). Macroscopical and microscopical assessments of the stomachs as well as gastric biopsy histological studies were carried out. OFI oil exhibited a high efficiency in the protection of the cytoarchitecture and function of the gastric mucosa against the severe damages provoked by ethanol intake. Ulcerated areas were very significantly reduced and the % of ulcer inhibition was the highest under OFI oil pretreatment. Mucus production was stimulated, gastric juice volume was reduced, and its pH was increased. Histopathological examination of H&E-stained biopsies collected from gastric mucosae from the different experimental groups confirmed the gastroprotective efficacy of OFI oil against ethanol-induced symptoms such as inflammation and damages like bleeding, erosions, lesions, necrosis, and ulcers. Furthermore, OFI oil treatment speeded-up the reduction of the surface of ethanol-induced ulcerated areas in a dose-dependent manner, leading to a time gain in the healing process. The healing rate reached 91% on day 2 and 99% on day 3, and a complete heal was attained at the fourth day under OFI oil treatment, while ulcer areas were still partially unhealed in all the other groups. The therapeutic effects of OFI oil against gastric ulcer could be mediated by its varied bioactive compounds that we have demonstrated in the analytical study. They could act synergistically or in a delayed manner to optimize the healing process through protective antioxidant properties, as well as an antagonism against histamine H2-receptors, a stimulation of the signaling pathways necessary for mucus and bicarbonate production, and reduction of inflammatory processes in the gastric mucosa. Additionally, OFI oil fatty acids (especially unsaturated) and triacylglycerols contribute to the reconstruction and the repair of the cell membrane lipid bilayer during the gastric ulcer healing process.

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