Résultats de la microscopie spéculaire au cours des uvéites actives

Zina, Sourour; Khochtali, Sana; Sayadi, Sana; Ksiaa, Imen; Abroug, Nesrine; Khairallah, Moncef

doi:10.1016/j.jfo.2020.10.024

Cited by 1 publication

(1 citation statement)

References 16 publications

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“…Several studies have examined how ACI affects corneal endothelial parameters and CCT. Some of the studies indicate that the presence of ACI is associated with significantly low ECD and HEX and high CV and CCT [5,22,24]; however, other studies have found no such differences [10,41,45]. The wide variations in the findings and the lack of information underscore the importance of this systematic review and meta-analysis for clarifying the effects of ACI on the endothelium and CCT.…”

Section: Discussionmentioning

confidence: 93%

Quantitative changes in the corneal endothelium and central corneal thickness during anterior chamber inflammation: A systematic review and meta-analysis

Mejía-Salgado,

Muñoz-Vargas,

Cifuentes-González

et al. 2024

PLoS ONE

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Purpose To establish the effects of anterior chamber inflammation (ACI) on the corneal endothelium parameters and central corneal thickness (CCT). Methods We conducted a comprehensive literature review using medical databases (PubMed, EMBASE, VHL, and medRxiv) on March 8, 2023, for studies that included patients with ACI who had undergone specular microscopy or pachymetry. Case series with >10 patients, cross-sectional, case-control, and cohort studies were included. The risk of bias was assessed using CLARITY tools and validated scales such as those by Hassan Murad et al. and Hoy et al. A narrative synthesis and a quantitative standardized mean difference meta-analysis, I2 heterogeneity assessment, and publication bias tests were conducted. The study was registered in PROSPERO (CRD42023420148) and approved by the Universidad del Rosario ethical committee (DVO005 2277- CV1712). Results Thirty-four studies, encompassing 1,388 eyes with ACI, were included. Compared with healthy controls, overall, ACI eyes show significant mean differences in endothelial parameters (endothelial cell density (ECD), coefficient of variation (CV), and hexagonality (HEX)) (P < 0.05). In the subgroup analysis compared with healthy controls, both active and chronic-recurrent ACI demonstrated a reduced ECD. An increased CV was observed in active, inactive, and chronic-recurrent ACI. Lower HEX was evident in inactive, acute, and chronic-recurrent ACI, while both active and acute ACI exhibited high CCT. Conclusion ACI leads to significant alterations in endothelial parameters and CCT. The primary contributors to these changes are increased IOP, uveitis duration, and intraocular surgeries. Further studies are needed to explore the impact of ACI etiology on the endothelium, potential biases in IOP measurements during acute ACI episodes, and the potential necessity for monitoring the endothelial parameters and CCT in patients with chronic ACI.

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