Resultados del programa de cribado prenatal de cromosomopatías en el área sanitaria sur de Sevilla, tras la implantación de la aplicación corporativa siPACAC

Camacho, I; González, Manuel; Bueno, José Antonio Sainz; Ortiz, A. Moro

doi:10.1016/j.gine.2016.07.001

Cited by 3 publications

(3 citation statements)

References 11 publications

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“…The rate of false positives (1%) and the positive predictive value of NIPS (93.3%) (95% CI: 68.05-99.83%) slightly exceed those reported by Peral Camacho et al [2], who reported a rate of false positives of 3.2% for a sample of 6,584 patients. Our results are also consistent with those obtained by other authors such as Norton et al [9], who reported a rate of false positives of 0.06% and a positive predictive value of 80.9% (95% CI: 66.7-90.9%) for a sample of 15,841 patients.…”

Section: Discussioncontrasting

confidence: 54%

“…New biochemical markers (pregnancy-associated plasma protein-A [PAPP-A]), and ultrasound markers (nuchal translucency [NT]) were incorporated to prenatal tests later. This way, detection rates increased to 85-90% for trisomy 21 [2].…”

Section: Introductionmentioning

confidence: 95%

“…After the implementation of PACAC, a corporative application was incorporated to the SSPA (siPACAC) to facilitate risk assessment during the first (total and free PAPP-A, β-hCG and NT before 14 weeks gestation), and second trimester (free β-hCG and alpha-fetoprotein) for T21 and other trisomies [2,3].…”

Section: Introductionmentioning

confidence: 99%

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Assessment of a change of protocol of prenatal screening by inclusion of non-invasive prenatal diagnosis

Cabra-Rodríguez

Rodríguez

Rosa

et al. 2020

Advances in Laboratory Medicine / Avances en Medicina De Laboratorio

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AbstractObjectivesNon-invasive prenatal screening (NIPS) is a test for the detection of major fetal chromosomal abnormalities in maternal blood during pregnancy. The purpose of this study was to assess the performance of NIPS implemented within the framework of the Screening Program for Congenital Abnormalities of the Andalusian Health System.MethodsA retrospective observational study was undertaken to determine the number of NIPS tests performed since its introduction. The number of invasive diagnostic tests done after the implementation of NIPS in the patients included in the program between March 2016 and August 2017 was also quantified.ResultsA total of 6,258 combined first- and second trimester screening tests were performed, covering 95% of the population. In total, 250 subjects were identified as high risk, of whom 200 underwent NIPS after loss to follow-up. NIPS showed a sensitivity of 100% (95% CI: 76.84–100%) and a specificity of 99.46% (95% CI: 97.04–99.99%).ConclusionsThis test has proven to have a very high sensitivity and specificity. The results obtained demonstrate that the incorporation of NIPS in clinical practice minimizes the rate of miscarriages and reduces the frequency of invasive procedures by 70%.

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Section: Discussioncontrasting

confidence: 54%

Section: Introductionmentioning

confidence: 95%

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Assessment of a change of protocol of prenatal screening by inclusion of non-invasive prenatal diagnosis

Cabra-Rodríguez

Rodríguez

Rosa

et al. 2020

Advances in Laboratory Medicine / Avances en Medicina De Laboratorio

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Comparación de biomarcadores de primer trimestre en gestantes normotensas según su grado de obesidad en el tercer trimestre

Muñoz¹,

Delgado²,

Alonso³

et al. 2021

Clínica e Investigación en Ginecología y Obstetricia

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Valoración de un cambio de protocolo del cribado prenatal mediante la inclusión del diagnóstico prenatal no invasivo

Cabra-Rodríguez

Rodríguez

Rosa

et al. 2020

Advances in Laboratory Medicine / Avances en Medicina De Laboratorio

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ResumenObjetivosEl diagnóstico prenatal no invasivo (DPNI) es un test que permite detectar en la sangre materna las principales alteraciones cromosómicas del feto durante el embarazo. El objetivo es evaluar el DPNI, valorando su rendimiento dentro del Programa Andaluz de Cribado de Anomalías Congénitas del Sistema Sanitario Público Andaluz.MétodosEstudio observacional retrospectivo en el que se analizan los DPNI realizados desde su incorporación, además del número de procedimientos diagnósticos invasivos tras la implementación del DPNI en gestantes incluidas en el programa entre marzo del año 2016 y agosto del 2017.ResultadosSe realizaron 6.258 cribados combinados en gestantes de primer y segundo trimestre, con una cobertura de la población del 95%; se obtuvo un cálculo de riesgo elevado (≥1/280) en 250 gestantes, de los cuales el DPNI se aplicó en 200 gestantes después de asumir las pérdidas. La sensibilidad obtenida fue de 100% (IC 95%:76,84 a 100%) y la especificidad de 99,46% (IC 95%:97,04 a 99,99%).ConclusionesEste test es muy sensible, con alta especificidad. En nuestro estudio, la incorporación del DPNI en la práctica clínica minimiza las pérdidas fetales y reduce en un 70% la realización de procedimientos invasivos.

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Resultados del programa de cribado prenatal de cromosomopatías en el área sanitaria sur de Sevilla, tras la implantación de la aplicación corporativa siPACAC

Cited by 3 publications

References 11 publications

Assessment of a change of protocol of prenatal screening by inclusion of non-invasive prenatal diagnosis

Assessment of a change of protocol of prenatal screening by inclusion of non-invasive prenatal diagnosis

Comparación de biomarcadores de primer trimestre en gestantes normotensas según su grado de obesidad en el tercer trimestre

Valoración de un cambio de protocolo del cribado prenatal mediante la inclusión del diagnóstico prenatal no invasivo

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