Restrictive versus liberal red blood cell transfusion strategies for people with haematological malignancies treated with intensive chemotherapy or radiotherapy, or both, with or without haematopoietic stem cell support

Radford, Michael; Estcourt, Lise J; Sirotich, Emily; Pitre, Tyler; Britto, Joanne; Watson, Megan; Brunskill, Susan J; Fergusson, Dean A; Dorée, Carolyn; Arnold, Donald M

doi:10.1002/14651858.cd011305.pub3

Cochrane Database of Systematic Reviews

2024

DOI: 10.1002/14651858.cd011305.pub3

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Restrictive versus liberal red blood cell transfusion strategies for people with haematological malignancies treated with intensive chemotherapy or radiotherapy, or both, with or without haematopoietic stem cell support

Michael Radford,

Lise J Estcourt,

Emily Sirotich

et al.

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2024

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Revisiting the full blood count: Circulating blood cells and their role in coagulation

Schofield,

Yong,

Toh

2024

Br J Haematol

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SummaryThere has been an expansion in our understanding of the multifaceted roles of circulating blood cells in regulating haemostasis and contributing to thrombosis. Notably, there is greater recognition of the interplay between coagulation with inflammation and innate immune activation and the contribution of leucocytes. The full blood count (FBC) is a time‐honoured test in medicine; however, its components are often viewed in isolation and without consideration of their haemostatic and thrombotic potential. Here, we review how the individual components of the FBC, that is, haemoglobin, platelets and leucocytes, engage with the haemostatic system and focus on both their quantitative and qualitative attributes. We also explore how this information can be harnessed into better management of people with multiple long‐term conditions because of their higher risk of adverse clinical events.

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Revisiting the full blood count: Circulating blood cells and their role in coagulation

Schofield,

Yong,

Toh

2024

Br J Haematol

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Restrictive versus liberal red blood cell transfusion strategies for people with haematological malignancies treated with intensive chemotherapy or radiotherapy, or both, with or without haematopoietic stem cell support

Cited by 1 publication

References 73 publications

Revisiting the full blood count: Circulating blood cells and their role in coagulation

Revisiting the full blood count: Circulating blood cells and their role in coagulation

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