Abstract:OBJECTIVE: To assess whether the incidence of hospital infection by a resistant microorganism decreased after the implementation of the restrictive measure of the National Health Surveillance Agency for the commercialization of antimicrobials. METHODS: A historical cohort study of medical records of adult patients admitted to a general and public hospital from May 2010 to July 2011. A cohort was formed with patients admitted in the period before the restrictive measure for the commercialization of antimicrobia… Show more
“…Another study conducted by the same group of researchers suggests that the implementation of the restrictive measure of the commercialization of antimicrobials by ANVISA reduced the incidence of hospital infection by a resistant microorganism [16].…”
Bacterial resistance to antimicrobial drugs (ATM) has become a global public health problem. The collegiate board of the National Health Surveillance Agency (ANVISA) through RDC 44, published on October 26, 2010, determined that prescribed antibiotics can only be dispensed with special control prescription, aiming to restrict the free access to these drugs and minimize the microbial resistance. The present study aims to identify microbial resistance in blood culture in hospitalized patients before and after the implementation of restrictive measurement. We observed decrease in the occurrence of blood culture microbial resistance in Phase II (0,62 for 100 people day) compared with Phase I (0,75 for 100 people day).
“…Another study conducted by the same group of researchers suggests that the implementation of the restrictive measure of the commercialization of antimicrobials by ANVISA reduced the incidence of hospital infection by a resistant microorganism [16].…”
Bacterial resistance to antimicrobial drugs (ATM) has become a global public health problem. The collegiate board of the National Health Surveillance Agency (ANVISA) through RDC 44, published on October 26, 2010, determined that prescribed antibiotics can only be dispensed with special control prescription, aiming to restrict the free access to these drugs and minimize the microbial resistance. The present study aims to identify microbial resistance in blood culture in hospitalized patients before and after the implementation of restrictive measurement. We observed decrease in the occurrence of blood culture microbial resistance in Phase II (0,62 for 100 people day) compared with Phase I (0,75 for 100 people day).
“…9 Alguns estudos apontam para as contribuições da medida restritiva no consumo de antimicrobianos em farmácias e drogarias, [10][11] assim como na redução da resistência no âmbito comunitário e hospitalar. 12 Além disso, estudos apontam que é necessário racionalização do uso para que as estratégias implementadas sejam efetivas. 13 Considerando que o consumo de antimicrobianos impacta na O consumo foi expresso por DDD por 1000 pacientes-dia, considerando a DDD de cada antimicrobiano no período do estudo de acordo com a DDD padrão estabelecida pela OMS.…”
Section: Introductionunclassified
“…A literatura científica já demonstra como a RB na comunidade influencia a RB no âmbito hospitalar. 12 Inclusive, um estudo realizado em hospital sugere que a medida restritiva contribuiu para diminuição de incidência de infecções hospitalares. 12,17 Mesmo com a diminuição da RB no hospital em estudo após a implementação da medida restritiva, 12 essa não é uma estratégia que por si só garante a racionalização da prescrição de antimicrobianos e consequentemente, diminuição no consumo.…”
Section: Introductionunclassified
“…12 Inclusive, um estudo realizado em hospital sugere que a medida restritiva contribuiu para diminuição de incidência de infecções hospitalares. 12,17 Mesmo com a diminuição da RB no hospital em estudo após a implementação da medida restritiva, 12 essa não é uma estratégia que por si só garante a racionalização da prescrição de antimicrobianos e consequentemente, diminuição no consumo. 18 Fatores como fragilidade das condições de saúde dos pacientes, proximidade dos leitos e medidas sanitárias precárias facilitam a disseminação de infecções cruzadas por micro-organismos resistentes, portanto devem ser evitados.…”
Introduction: The consumption of antimicrobials (ATB) has been described as one of the causes of Bacterial Resistance. In 2010, RDC 44 was published in Brazil, which restricts the free sale of ATB to reduce antimicrobial resistance in hospitals. Aim: to identify the consumption of ATB in a teaching hospital before and after the implementation of the restrictive measure on the commercialization of antimicrobials in Brazil. Outlining: Cross sectional study carried out in a general hospital. Analyzes were carried out in two phases, using the variables ATB consumption, expressed in defined daily dose (DDD), average use of different ATB per patient and the frequency of resistant microorganisms in the period. Results: The average use of ATB per patient was 2.56 (Standard Deviation (SD) ± 2.02) and2.40 (SD ± 1.89) in phases I and II, respectively (p=0.0007). The general variation in defined daily dose was 1.89%, however drugs with negative variation were observed. A higher frequency of resistant microorganisms isolated in phase I was observed compared to phase II (OR=1.48, CI: 1.13-1.93, respectively). Implications: A difference was identified in the consumption of ATB between the periods, with an increase in general consumption, in DDD, but a lower average number of different ATBs per patient and a lower occurrence of resistant microorganisms.
Background:
Bacterial resistance to antibiotics is a growing problem in all countries and has
been discussed worldwide. In this sense, the development of new drugs with antibiotic properties is
highly desirable in the context of medicinal chemistry.
Methodology:
In this paper we investigate the antioxidant and antibacterial potential of sulfonamides
derived from carvacrol, a small molecule with drug-like properties. Most sulfonamides had antioxidant
and antibacterial potential, especially compound S-6, derived from beta-naphthylamine.
Result:
To understand the possible mechanisms of action involved in biological activity, the experimental
results were compared with molecular docking data.
Conclusion:
This research allows appropriate discussion on the identified structure activity relationships.
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