Restrictions of developmental capabilities in neural crest cell derivatives as tested by in vivo transplantation experiments

Lièvre, Christiane Ayer-Le; Schweizer, G; Ziller, Catherine; Douarin, Nicole M. Le

doi:10.1016/0012-1606(80)90481-9

Cited by 186 publications

(68 citation statements)

References 12 publications

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“…Neural crest cells migrate long distances before differentiation, providing a model for the investigation of cell differentiation, cell migration and cell-to-cell interaction. The neural crest cells follow a precise region-specific pathway, and they differentiate into many kinds of cells: sensory, sympathetic and parasympathetic neurons, Schwann cells, glial cells of the peripheral nervous system, melanocytes, and cartilages, bones and connective tissues of the head and neck, and some endocrine cells (reviewed by WESTON, 1970;NODEN, 1978;LE DOUARIN, 1980). Soon after leaving the neural primordium, neural crest cells become indistinguishable from the cells of the neighboring tissues through which they migrate.…”

Section: Discussionmentioning

confidence: 99%

Mesenchymal derivatives from the neural crest.

Nakamura

1982

Arch. Histol. Jap., Arch. Histol. Jpn

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Section: Discussionmentioning

confidence: 99%

Mesenchymal derivatives from the neural crest.

Nakamura

1982

Arch. Histol. Jap., Arch. Histol. Jpn

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“…In fact, both in vivo lineage tracing experiments (Le Lievre et al, 1980;Bronner-Fraser and Fraser, 1989;Frank and Sanes, 199 1) and clonal analysis in vitro (Sieber-Blum and Cohen, 1980;Baroffio et al, 1988) have demonstrated the existence of pluripotent progenitors both in the neural crest and in the migrating crest populations.…”

Section: Stem Cell Factor Is a Neurotrophicmentioning

confidence: 99%

Stem cell factor is a neurotrophic factor for neural crest-derived chick sensory neurons

1994

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We have found that stem cell factor (SCF) selectively enhances the survival of cultured embryonic chick dorsal root ganglia (DRG) neurons. Neurons grown in the presence of SCF expressed both neurofilament 150 kDa subunit and calcitonin-gene related peptide. SCF does not, however, enhance the survival of parasympathetic, placode-derived sensory or sympathetic neurons in culture. Combining SCF with brain-derived neurotrophic factor or neurotrophin-3, but not with NGF, maintains more neurons than either factor alone, suggesting that these factors have partially overlapping activities. SCF preferentially rescues small neurons from the DRG. Labeling studies with bromodeoxyuridine indicate that the neurons sustained by SCF are not differentiating from a dividing progenitor.

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“…When they begin to emigrate from the dorsal region of the neural tube, many neural crest cells are pluripotent in the sense that they are capable of generating more than one phenotype (Sieber-Blum and Cohen, 1980;BronnerFraser and Fraser, 1988;Sieber-Blum, 1989). Other neural crest cells appear committed to the sensory neuron (Le Lievre et al, 1980;Sieber-Blum, 1989a), melanogenic (Sieber-Blum and Cohen, 1980) or smooth myogenic cell lineages (Ito and Sieber-Blum, 1991).…”

Section: Introductionmentioning

confidence: 99%

Mitogenic and anti‐proliferative signals for neural crest cells and the neurogenic action of TGF‐β1

1997

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The influence of pertinent growth factors on proliferation and differentiation of quail neural crest cell was assessed by in vitro colony assay in a serum-free (0.5% chick embryo-extract supplemented) culture medium. The factors tested included basic fibroblast growth factor (bFGF; FGF-2), neurotrophins, and transforming growth factor-beta-1 (TGF-b). Both bFGF and neurotrophins are implicated in the development of the peripheral nervous system, whereas TGF-b can affect cell differentiation and modulate the action of other growth factors. Bromodeoxyuridine (BrdU) incorporation indicated that bFGF is mitogenic to pluripotent neural crest cells (and/or their immediate progeny) and to committed melanogenic cells. However, this was not reflected in an increase in colony size. In contrast, colony size did increase when nerve growth factor (NGF) was present in addition to bFGF. This indicated either that both factors are required to initiate cell proliferation or that at least some bFGF-exposed cells become dependent on neurotrophins for survival. Sequential addition of the factors showed that exposure to bFGF was required prior to the presence of a neurotrophin, thus favoring the latter possibility. All three neurotrophins tested, NGF, brainderived neurotrophic factor (BDNF), and neurotrophin-3 (NT-3), were capable of supporting survival of pluripotent neural crest cells (or their closely related progeny) in the presence of bFGF. In the absence of bFGF, neurotrophins did not affect colony size. Although the BrdU data indicated that bFGF is also a mitogen for committed melanogenic cells, the size of pigmented colonies did not change in the presence of bFGF alone or of bFGF plus a neurotrophin. This suggested that another, yet to be determined, factor is required for the survival of proliferating melanogenic cells.

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Restrictions of developmental capabilities in neural crest cell derivatives as tested by in vivo transplantation experiments

Cited by 186 publications

References 12 publications

Mesenchymal derivatives from the neural crest.

Mesenchymal derivatives from the neural crest.

Stem cell factor is a neurotrophic factor for neural crest-derived chick sensory neurons

Mitogenic and anti‐proliferative signals for neural crest cells and the neurogenic action of TGF‐β1

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