Restricted versus liberal oxygen exposure for preventing morbidity and mortality in preterm or low birth weight infants

Abstract

Analysis 1.4. Comparison 1 Restricted versus liberal oxygen therapy (all preterm/LBW infants) in early neonatal period, Outcome 4 Vascular RLF (severe stages

The German ROP Registry: data from 90 infants treated for retinopathy of prematurity

“…Overall incidence rates of ROP requiring treatment, however, were similar between our study (3.2% of screened infants) and the Swedish population (4.2%) (Holmstrom et al 2015). It is well established that systemic comorbidities and postnatal oxygen supplementation are associated with the development of severe ROP (Karna et al 2005;Askie et al 2009;Ying et al 2015). This was confirmed in our study population.…”

The German ROP Registry: data from 90 infants treated for retinopathy of prematurity

“…Overall incidence rates of ROP requiring treatment, however, were similar between our study (3.2% of screened infants) and the Swedish population (4.2%) (Holmstrom et al 2015). It is well established that systemic comorbidities and postnatal oxygen supplementation are associated with the development of severe ROP (Karna et al 2005;Askie et al 2009;Ying et al 2015). This was confirmed in our study population.…”

Impact of the Koala Project on clinical outcomes of preterm infants in two maternity hospitals

“… 8 A meta-analysis evaluated the adverse effects, such as increased incidence of ROP, which were associated with high levels of inspiratory fraction of oxygen in preterm infants. 1 …”

“…8 A meta-analysis evaluated the adverse effects, such as increased incidence of ROP, which were associated with high levels of inspiratory fraction of oxygen in preterm infants. 1 ROP demands a multidisciplinary approach to reduce adverse situations in the management of premature children and requires the involvement of a qualified and trained team, composed of neonatologists, nurses, nursing technicians and ophthalmologists. This is in order to implement an effective program of screening and prevention of blindness by ROP.…”

The Impact of Hypoxemia on the Development of Retinopathy of Prematurity in Infants Less Than 29 Weeks of Gestation

“…[14][15][16] During the prolonged stay of very premature infants, they are exposed to many potential oxidative stresses and inflammatory challenges including infections, PDA, NEC, and circulatory failure. 2,17,18 The inflammatory mediators associated with these form a common pathway for cellular damage and all adverse outcomes (►Fig. 4).…”

“…The trend in the previous decade of neonatal practice has been to accept a lower target oxygen saturation with an aim to decrease the incidence of hyperoxemia and hence the incidence of severe ROP and BPD. 2,17,22 There is no consensus on the best oxygen target limits despite controlled trials. 2,7,23 This is, in part, because of the limitations of pulse oximetry and significant overlap between selected targets.…”

The German ROP Registry: data from 90 infants treated for retinopathy of prematurity

“…Overall incidence rates of ROP requiring treatment, however, were similar between our study (3.2% of screened infants) and the Swedish population (4.2%) (Holmstrom et al 2015). It is well established that systemic comorbidities and postnatal oxygen supplementation are associated with the development of severe ROP (Karna et al 2005;Askie et al 2009;Ying et al 2015). This was confirmed in our study population.…”

Impact of the Koala Project on clinical outcomes of preterm infants in two maternity hospitals

“… 8 A meta-analysis evaluated the adverse effects, such as increased incidence of ROP, which were associated with high levels of inspiratory fraction of oxygen in preterm infants. 1 …”

“…8 A meta-analysis evaluated the adverse effects, such as increased incidence of ROP, which were associated with high levels of inspiratory fraction of oxygen in preterm infants. 1 ROP demands a multidisciplinary approach to reduce adverse situations in the management of premature children and requires the involvement of a qualified and trained team, composed of neonatologists, nurses, nursing technicians and ophthalmologists. This is in order to implement an effective program of screening and prevention of blindness by ROP.…”

The Impact of Hypoxemia on the Development of Retinopathy of Prematurity in Infants Less Than 29 Weeks of Gestation

“…[14][15][16] During the prolonged stay of very premature infants, they are exposed to many potential oxidative stresses and inflammatory challenges including infections, PDA, NEC, and circulatory failure. 2,17,18 The inflammatory mediators associated with these form a common pathway for cellular damage and all adverse outcomes (►Fig. 4).…”

“…The trend in the previous decade of neonatal practice has been to accept a lower target oxygen saturation with an aim to decrease the incidence of hyperoxemia and hence the incidence of severe ROP and BPD. 2,17,22 There is no consensus on the best oxygen target limits despite controlled trials. 2,7,23 This is, in part, because of the limitations of pulse oximetry and significant overlap between selected targets.…”

The German ROP Registry: data from 90 infants treated for retinopathy of prematurity

“…Overall incidence rates of ROP requiring treatment, however, were similar between our study (3.2% of screened infants) and the Swedish population (4.2%) (Holmstrom et al 2015). It is well established that systemic comorbidities and postnatal oxygen supplementation are associated with the development of severe ROP (Karna et al 2005;Askie et al 2009;Ying et al 2015). This was confirmed in our study population.…”

Impact of the Koala Project on clinical outcomes of preterm infants in two maternity hospitals

“… 8 A meta-analysis evaluated the adverse effects, such as increased incidence of ROP, which were associated with high levels of inspiratory fraction of oxygen in preterm infants. 1 …”

“…8 A meta-analysis evaluated the adverse effects, such as increased incidence of ROP, which were associated with high levels of inspiratory fraction of oxygen in preterm infants. 1 ROP demands a multidisciplinary approach to reduce adverse situations in the management of premature children and requires the involvement of a qualified and trained team, composed of neonatologists, nurses, nursing technicians and ophthalmologists. This is in order to implement an effective program of screening and prevention of blindness by ROP.…”

The Impact of Hypoxemia on the Development of Retinopathy of Prematurity in Infants Less Than 29 Weeks of Gestation

“…[14][15][16] During the prolonged stay of very premature infants, they are exposed to many potential oxidative stresses and inflammatory challenges including infections, PDA, NEC, and circulatory failure. 2,17,18 The inflammatory mediators associated with these form a common pathway for cellular damage and all adverse outcomes (►Fig. 4).…”

“…The trend in the previous decade of neonatal practice has been to accept a lower target oxygen saturation with an aim to decrease the incidence of hyperoxemia and hence the incidence of severe ROP and BPD. 2,17,22 There is no consensus on the best oxygen target limits despite controlled trials. 2,7,23 This is, in part, because of the limitations of pulse oximetry and significant overlap between selected targets.…”