Restricted diet modifies carbohydrate metabolism in immature rats

Lanfri-Aguilar, N.; Gallará, Raquel Vivian; Linares, J.A.; Campos, L.M.; Finkelberg, A.

doi:10.1016/j.plefa.2006.06.006

Cited by 2 publications

(2 citation statements)

References 18 publications

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“…Varios investigadores han establecido la dependencia de las glándulas submandibulares de los mecanismos de glucogenólisis y glucólisis como principales fuentes metabólicas para llevar a cabo la secreción salival 7 . De este modo, las variaciones del metabolismo del glucógeno glandular son utilizadas in vitro como indicador de la actividad funcional de las mismas 8 . En el presente trabajo la concentración inicial de glucógeno glandular fue significativamente menor en el grupo tratado con Cf respecto de los grupos control y alimentación apareada.…”

Section: Discussionunclassified

Efecto de ciclofosfamida sobre el metabolismo de los hidratos de carbono en glándula submandibular de ratas

Mazzeo¹,

Bachmeier²,

López³

et al. 2018

RevFacOdont

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Efecto de ciclofosfamida sobre el metabolismo de los hidratos de carbono en glándula submandibular de ratasEffect of cyclophosphamide on the metabolism of carbohydrates in the submandibular gland of rats AbstractObjective: During the period of chemotherapy, the appearance of serious systemic toxicities is one of the main clinical problems, among which are those related to the stomatognathic system. Cyclophosphamide is a drug widely used in solid tumors and bone marrow transplantation. The objective of this work was to evaluate the toxicity of cyclophosphamide on the functional activity of the submandibular glands of Wistar rats in an experimental model. Methods: We used 42 male Wistar rats aged 3 months, housed in individual cages, with temperature and controlled lighting and free diet. They were divided into three experimental groups: 1) Control (C), 2) treated with cyclophosphamide (Cf,) applying an i.p. of 50 mg / Kg of body weight during two consecutive days and 3) rats with paired feeding (AA): during two days the amount administered resulted from the average of the ingested food of group 2 .Both submandibular glands were removed. The submandibular glycogen concentration was analyzed in initial time (t0) and after 60 minutes of mechanical stimulation (t60). Results: The average variations changed significantly between time 0 and 60 in groups C and AA (p-value = 0.0001), Cf had a lower average concentration in time 0 with respect to C and AA, without significant consumption in time 60. Conclusion: Cf would affect the metabolism of carbohydrates, decreasing the use of glycogen as a metabolic substrate. In the present experimental model the toxicity of this drug reduces the functional activity of the submandibular gland.

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Section: Discussionunclassified

Efecto de ciclofosfamida sobre el metabolismo de los hidratos de carbono en glándula submandibular de ratas

Mazzeo¹,

Bachmeier²,

López³

et al. 2018

RevFacOdont

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“…We have not found reports in the literature on experimental activities related to the toxic effects of these drugs on the metabolism of carbohydrates in the salivary glands. [18][19] 5-FU administration would affect glandular activity by blocking the metabolism of carbohydrates alone, while synergic action of both drugs (5-Fu+LV) would depress metabolic and nervous activity resulting in hyposalivation. 13 However, it is important to point out that our laboratory and other authors refer to clinical alterations in the stomatognathic system and in particular in salivary glands and the quality of their secretion during the chemotherapy phase.…”

Section: Rats Treated With Cyclophosphamidementioning

confidence: 99%

5-Fluorouracil and Cyclophosphamide modify functional activity in submandibular gland of rats.

et al. 2020

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Objective: Chemotherapy treatment against cancer produce systemic toxicities, among which are those related to important structures of the stomatognathic system and its functional activity. 5 Fluorouracil (5-FU) and cyclophosphamide (Cf) are drugs widely used in solid tumors and in bone marrow transplantation, respectively. The objective of this work was to evaluate the toxicity of these drugs regarding functional activity of the submandibular glands, by measuring the percentage of glycogen consumption in two experimental models. Material and Methods: 84 male Wistar rats aged three months were used, housed in individual cages, with controlled temperature and lighting and ad libitum diet. They were divided into four experimental groups: 1) Control (C); 2) Treated with 5-FU+leucovorin (LV) at 20 and 10mg/Kg of body weight respectively for five consecutive days; 3) treated with Cf i.p. at 50mg/Kg of body weight for two consecutive days; and 4) rats with paired feeding (PF): for five and two days respectively, the amount administered resulted from the average of the ingested food of groups 2 and 3. Both submandibular glands were excised. The submandibular glycogen concentration was analyzed at initial time (t0) and after 60 minutes of mechanical stimulation (t60). Results: the average variation changed significantly between time 0 and 60 in the groups C and PF. (p-value=0.0001), the 5-FU + LV treatment group had an average concentration higher at t0 than groups C and PF, without significant consumption at T60. While group Cf showed a lower average concentration at time 0 with respect to groups C and PF, without significant consumption at T60. Conclusion: 5-FU+LV and Cf affect the metabolism of carbohydrates, decreasing the use of glycogen as a metabolic substrate. In the present experimental model, the toxicity of these drugs affected the functional activity of the submandibular gland.

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Restricted diet modifies carbohydrate metabolism in immature rats

Cited by 2 publications

References 18 publications

Efecto de ciclofosfamida sobre el metabolismo de los hidratos de carbono en glándula submandibular de ratas

Efecto de ciclofosfamida sobre el metabolismo de los hidratos de carbono en glándula submandibular de ratas

5-Fluorouracil and Cyclophosphamide modify functional activity in submandibular gland of rats.

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