Restraint stress differentially affects anti-viral cellular and humoral immune responses in mice

Sheridan, John F.; Feng, Ningguo; Bonneau, Robert H.; Allen, Carl M.; Huneycutt, Brandon S.; Glaser, Ronald

doi:10.1016/0165-5728(91)90046-a

Cited by 158 publications

(62 citation statements)

References 33 publications

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“…Thus the change in NK cells was both necessary and sufficient to produce the facilitation of tumor development. The same sort of conclusion can be drawn from work by Bonneau et al (1991aBonneau et al ( , 1991 using the herpes simplex virus. More work of this sort will be needed before we can make confident assertions about links to disease.…”

Section: Implications For Diseasesupporting

confidence: 57%

“…The immune system contains a high degree of redundancy, and so the fact that an event might alter an intermediate product or step does not provide convincing information about whether the event in question would impact on a normal endpoint of the immune response (e.g., the production of antibody). Indeed, there are instances in which a condition influences one but not the other (Cunnick, Lysle, Armfield, & Rabin, 1991;Sheridan et al, 1991). It will take a considerable amount of research to distill the truly general principles from the specifics.…”

Section: Stress and Immunitymentioning

confidence: 99%

See 1 more Smart Citation

Psychoneuroimmunology: The interface between behavior, brain, and immunity.

Maier¹,

Watkins²,

Fleshner³

1994

American Psychologist

323

168

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Psychoneuroimmunology is the study of interactions between behavior, the brain, and the immune system. This article is designed to provide an overview of this new field for the general psychologist. The existence of bidirectional communication pathways between the brain and the immune system and the implications of this network for behavior are emphasized. Implications are that behavioralpsychological processes ought to be capable of altering immune function and that events that occur as part of immune responses should modulate behavior. Evidence for influences in both of these directions is reviewed. The discussion of psychological modulation of immunity focuses on classical conditioning and stress, whereas that of immune modification of behavior highlights behavioral effects produced by substances released by the immune system. Finally, the adaptive role that such changes might play is considered. Lyle E. Bourne served as action editor for this article.

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Section: Implications For Diseasesupporting

confidence: 57%

Section: Stress and Immunitymentioning

confidence: 99%

Psychoneuroimmunology: The interface between behavior, brain, and immunity.

Maier¹,

Watkins²,

Fleshner³

1994

American Psychologist

323

168

View full text Add to dashboard Cite

show abstract

“…Another possibility is that impaired cytokine production is limiting NK cell activation and recruitment. Specifically, IL-2, IL-12, and IL-15 are required for NK cell responses (Ferlazzo et al, 2004;Moretta et al, 2006;Puzanov et al, 1996), and the production of each of these cytokines has been shown to be suppressed during chronic stress (Hunzeker et al, 2004;Sheridan et al, 1991).…”

Section: Psychological Stress Impairs the Early Innate Immune Responsmentioning

confidence: 99%

Psychological stress exacerbates primary vaginal herpes simplex virus type 1 (HSV-1) infection by impairing both innate and adaptive immune responses

Ashcraft¹,

Bonneau²

2008

Brain, Behavior, and Immunity

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Chronic psychological stress is generally immunosuppressive and contributes to an increase in herpes simplex virus (HSV) pathogenicity. We have previously shown that mice experiencing stress at the time of intranasal HSV infection have increased levels of infectious virus in their nasal cavity, as compared to control mice that were not subjected to stress. We have extended our studies to determine the effects of stress at another clinically-relevant mucosal site by examining the immune response to and pathogenesis of vaginal HSV infection. Mice experiencing psychological stress during vaginal HSV infection exhibited an increase in both vaginal viral titers and the pathology associated with this HSV infection. We demonstrate that these observations result from the failure of both the innate and HSV-specific adaptive immune responses. At two days post-infection, NK cell numbers were significantly decreased in mice experiencing restraint stress. Studies examining the adaptive immune response revealed a decrease in the number of HSV-specific CD8 + T cells in not only the vaginal tissue itself but also the draining iliac lymph nodes (ILN). Furthermore, the number of functional cells, in terms of both their degranulation and interferon-γ production, in the ILN of stressed mice was decreased as compared to non-stressed mice. We conclude that psychological stress, through its suppression of both innate and adaptive immune responses, may be an important factor in the ability to control vaginal HSV infection.

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“…A ten-dency for normalization of all these parameters to the control levels was observed. It was found that restraint stress elevates plasma corticoid and tissue catecholamine levels and reduces cellular accumulation and inflammation in target organs associated with influenza virus infection (Scheridan et al 1991). This fact partially explains the stabilizing role of combined application of influenza virus infection and immobilization on liver cytochromes and monooxygenases.…”

Section: Discussionmentioning

confidence: 75%

Effect of immobilization, cold and cold-restraint stress on liver monooxygenase activity and lipid peroxidation of influenza virus-infected mice

Mileva

Bakalova

Tancheva

et al. 2002

Archives of Toxicology

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To cite this version:M. Mileva, R. Bakalova, L. Tancheva, S. Galabov. Effect of immobilization, cold and cold-restraint stress on liver monooxygenase activity and lipid peroxidation of influenza virus-infected mice.. Archives of Toxicology, Springer Verlag, 2002, 76 (2) Abstract The present study provides a direct experimental evidence that the combination of influenza A/ Aichi/2/68 (H3N2) infection with different models of ''oxidative stress'', such as immobilization, cold and cold-restraint, is associated with graduated oxidative disturbances in the liver of mice, despite the absence of virus and inflammation in this tissue. It was found that experimental influenza virus infection is accompanied with a significant increase of lipid peroxidation products, a decrease of natural antioxidants (vitamin E, glutathione) and cytochrome P-450, an inhibition of cytochrome c reductase and liver monooxygenases (analgin-Ndemethylase and amidopyrine-N-demethylase). Immobilization and cold stress, applied separately or in combination (cold-restraint), did not influence significantly any of the analysed parameters compared to those of the control group of non-infected mice. Preliminary exposure of mice to immobilization or cold stress and subsequent inoculation of influenza virus resulted in a significant increase of lipid peroxidation products and a significant decrease of vitamin E and reduced glutathione, compared with levels in control (non-infected) animals. Compared to influenza virus-infected and nonstressed animals, the changes in all these parameters were negligible. Immobilization or cold stress, applied in combination with influenza virus infection, partially prevented the suppressive effect of influenza virus on cytochrome P-450 and liver monooxygenases. A tendency towards normalization of these parameters to the control levels was observed. However, after application of cold-restraint plus influenza virus infection, the level of cytochrome P-450 and activity of cytochrome c reductase stayed markedly lower than in infected and non-stressed animals. The activities of liver monooxygenases were slightly increased compared with those of infected and non-stressed animals, but stayed relatively low compared to control (non-infected) mice. Combination of coldrestraint and influenza virus infection resulted in a greater synergistic increase of lipid peroxidation products and a greater synergistic decrease of vitamin E and reduced glutathione compared to controls, as well as to influenza virus-infected and non-stressed animals.

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Restraint stress differentially affects anti-viral cellular and humoral immune responses in mice

Cited by 158 publications

References 33 publications

Psychoneuroimmunology: The interface between behavior, brain, and immunity.

Psychoneuroimmunology: The interface between behavior, brain, and immunity.

Psychological stress exacerbates primary vaginal herpes simplex virus type 1 (HSV-1) infection by impairing both innate and adaptive immune responses

Effect of immobilization, cold and cold-restraint stress on liver monooxygenase activity and lipid peroxidation of influenza virus-infected mice

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