Restraint stress affects circulating NUCB2/nesfatin-1 and phoenixin levels in male rats

Schalla, Martha A.; Goebel-Stengel, Miriam; Friedrich, Tiemo; Kühne, Stephanie Gladys; Kobelt, Peter; Rose, Matthias; Stengel, Andreas

doi:10.1016/j.psyneuen.2020.104906

Cited by 18 publications

(16 citation statements)

References 39 publications

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“…These opposing effects have also been shown regarding anxiety-phoenixin exerting anxiolytic effects in mice [43], as well as being negatively associated with anxiety in humans [42], while nesfatin-1 increases anxiety-like behavior in rats [62] and being positively associated with higher anxiety in humans [48]. Similar results were seen after restraint stress, where phoenixin serum levels were decreased, while nesfatin-1 levels rose, although these effects were less pronounced [66]. In addition, both phoenixin and nesfatin-1 immunoreactivity were increased after restraint stress in the NTS and RPa in rodents, while showing a distinctly different pattern of expression in other nuclei [65,76], possibly modulating the relay of peripheral signals from baro-and osmoreceptors in the NTS to the PVN [96,97] and thereby, balancing physiological reactions to stress to avoid an excessive response.…”

Section: Interactionsmentioning

confidence: 55%

“…This coincided with an increase in serum cortisol levels, differing significantly compared to control animals after 30 min for the whole observation period of 4 h [66]. Phoenixin levels were, however, not correlated to cortisol levels [66]. The measured phoenixin serum levels were positively correlated with nesfatin-1 levels (r = 0.38) [66], further suggesting a possible interaction of these two peptides.…”

Section: Potential Involvement In Stress Responsementioning

confidence: 74%

“…Phoenixin levels were, however, not correlated to cortisol levels [66]. The measured phoenixin serum levels were positively correlated with nesfatin-1 levels (r = 0.38) [66], further suggesting a possible interaction of these two peptides.…”

Section: Potential Involvement In Stress Responsementioning

confidence: 78%

“…We showed a significant increase in central expression of phoenixin in rats subjected to restraint stress, a well-established emotional stressor, correlating with c-Fos activity in the DMN, mNTS and RPa [65], suggesting an involvement of phoenixin in the psychological stress response (Figure 1). The plasma concentration of phoenixin after restraint stress was significantly decreased 15 min after restraint stress and differedalthough not significantly-until 60 min after restraint [66]. This coincided with an increase in serum cortisol levels, differing significantly compared to control animals after 30 min for the whole observation period of 4 h [66].…”

Section: Potential Involvement In Stress Responsementioning

confidence: 78%

“…The plasma concentration of phoenixin after restraint stress was significantly decreased 15 min after restraint stress and differedalthough not significantly-until 60 min after restraint [66]. This coincided with an increase in serum cortisol levels, differing significantly compared to control animals after 30 min for the whole observation period of 4 h [66]. Phoenixin levels were, however, not correlated to cortisol levels [66].…”

Section: Potential Involvement In Stress Responsementioning

confidence: 79%

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Role of the Novel Peptide Phoenixin in Stress Response and Possible Interactions with Nesfatin-1

Friedrich

Stengel

2021

IJMS

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The novel peptide phoenixin was shown to be involved in several physiological processes ranging from reproduction to food intake. Interest in this protein has steadily increased over the last few years and its known implications have become much broader, playing a role in glucose homeostasis, anxiety, nociception, and pruritus. Phoenixin is expressed in a multitude of organs such as the small intestine, pancreas, and in the hypothalamus, as well as several other brain nuclei influencing numerous physiological functions. Its highly conserved amino-acid sequence amongst species leads to the assumption, that phoenixin might be involved in essential physiological functions. Its co-expression and opposing functionality to the extensively studied peptide nesfatin-1 has given rise to the idea of a possible counterbalancing role. Several recent publications focused on phoenixin’s role in stress reactions, namely restraint stress and lipopolysaccharide-induced inflammation response, in which also nesfatin-1 is known to be altered. This review provides an overview on the phoenixins and nesfatin-1 properties and putative effects, and especially highlights the recent developments on their role and interaction in the response to response.

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