ReStore: A wireless peripheral nerve stimulation system

Sivaji, Vishnoukumaar; Grasse, Dane W.; Hays, Seth A.; Bucksot, Jesse E; Saini, Rahul; Kilgard, Michael P.; Rennaker, Robert L.

doi:10.1016/j.jneumeth.2019.02.010

Cited by 32 publications

(23 citation statements)

References 39 publications

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“…The circumferential electrodes were made using the same materials and protocol as the rat cuff electrodes but sized to accommodate the larger rabbit sciatic nerve (3 mm inner diameter, 4.5 mm outer diameter, 270° arc). Flat electrodes consisted of PCBs connected to two rectangular platinum contacts [35]. All on-board components were encapsulated and hermetically sealed in glass.…”

Section: Methodsmentioning

confidence: 99%

Flat electrode contacts for vagus nerve stimulation

et al. 2019

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The majority of available systems for vagus nerve stimulation use helical stimulation electrodes, which cover the majority of the circumference of the nerve and produce largely uniform current density within the nerve. Flat stimulation electrodes that contact only one side of the nerve may provide advantages, including ease of fabrication. However, it is possible that the flat configuration will yield inefficient fiber recruitment due to a less uniform current distribution within the nerve. Here we tested the hypothesis that flat electrodes will require higher current amplitude to activate all large-diameter fibers throughout the whole cross-section of a nerve than circumferential designs. Computational modeling and in vivo experiments were performed to evaluate fiber recruitment in different nerves and different species using a variety of electrode designs. Initial results demonstrated similar fiber recruitment in the rat vagus and sciatic nerves with a standard circumferential cuff electrode and a cuff electrode modified to approximate a flat configuration. Follow up experiments comparing true flat electrodes to circumferential electrodes on the rabbit sciatic nerve confirmed that fiber recruitment was equivalent between the two designs. These findings demonstrate that flat electrodes represent a viable design for nerve stimulation that may provide advantages over the current circumferential designs for applications in which the goal is uniform activation of all fascicles within the nerve.

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Section: Methodsmentioning

confidence: 99%

Flat electrode contacts for vagus nerve stimulation

et al. 2019

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“…For example, electrophysiological recordings based on optimized application-specific integrated circuits (ASICs) can consume as low as a few microwatts per channel 34,[127][128][129][130] , whereas photometric recordings typically require average powers in the range of milliwatts 131 . Even with a given operation modality, power consumption may differ depending on implant location 100,119,122,132 (Table 2).…”

Section: Power Sources and Wireless Communicationmentioning

confidence: 99%

Wireless and battery-free technologies for neuroengineering

et al. 2021

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“…Copyright 2015, AAAS. References in alphabetical order: Blaschke 2017, Canales 2015, Castagnola 2015, Chang 2013, Choi 2017, Chung 2014, Escabi 2014, Fang 2017, Feili 2008, Ferlauto 2018, Jeong 2015, Johnson 2018, Khodagholy 2013, Khodagholy 2015, Kim 2010a, Kim 2010b, Kim 2012, Kim 2013, Kim 2016, Kim 2019, Lee 2016, Lee 2017, Liu 2015, Liu 2019, Lu 2014, Lu 2017, Lu 2018, Luo 2016, Mathieson 2012, Mestais 2015, Mickle 2019, Minev 2015, Montgomery 2015, Muller 2015, Noh 2018, Park 2014, Park 2015, Park 2016a, Park 2016b, Park 2017, Piech 2018, Qi 2015, Reeder 2014, Rodriguez 2000, Rubehn 2009, Samineni 2017, Schuettler 2000, Sekitani 2016, Seo 2016, Shin 2017, Sivaji 2019, Song 2005, Tybrandt 2018, Viventi 2010, Viventi 2011, Volk 2015, Walter 2005, Williamson 2015, Xie 2015, Yokota 2015, Zhang 2019, Zhou 2017 …”

Section: Function and Compliance Of Bioelectronic Systemsmentioning

confidence: 99%

Conformable Hybrid Systems for Implantable Bioelectronic Interfaces

2019

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of Things (IoT) to wellness and medical technologies. In the past decade, significant efforts have been deployed to exploit these technologies to design and manufacture conformable bioelectronic interfaces.Mechanical compliance is a critical specification for the long-term integration of on-skin devices and implants with a biological host. The latter is largely composed of soft tissues, with Young's moduli E in the range from 100 Pa to 10 MPa (excluding bones and cartilage), [1] and sustains different physiological dynamic behaviors, e.g., repeated displacements of hundreds of micrometers at 1 Hz in the heart or brain, [2] volumetric changes up to 8% in the heart, [3] or large flexion and angular displacement in the skin or spinal cord. [4] In contrast, electronic materials are stiff, with the elastic modulus in the range of 1 GPa (organic materials) to 100 GPa (inorganic materials) and rigid, bearing little strain without displaying mechanical failure or defect generation. Interfaces between such disparate biological and man-made materials suffer therefore from a mechanical mismatch that hinders reliable and continued device function in the body. [1,5] Several approaches have been used to engineer mechanical compliance within an electronic device or circuit. [6] Outcomes of such conformable circuits include improved mitigation of foreign body reaction (FBR) in vivo compared to rigid interfaces, [7] access to so far unreachable regions, [8] and bidirectional communication with high spatiotemporal resolution with the biological host.Monolithic integration of electronic devices and circuits on semiconductor wafers offers extreme miniaturization and very high device density (e.g., >10 8 transistors mm −2 , Intel FinFET Technology nodes [9] ). Such large scale of integration cannot be achieved for electronics prepared on conformable carrier substrates, as this class of devices employs lower performance device materials and polymeric substrates with low chemical and/or thermal stability leading to limited lithographic resolution and large transistor sizes. These constraints typically worsen as the compliance of the substrate increases. Some of the highest device densities reported to date are >10 000 cm −2 on flexible substrate [10] and 347 cm −2 on stretchable carrier. [11] Conformable hybrid systems leverage the performance of standard complementary metal-oxide-semiconductor integrated circuits (ICs) and the compliance of discrete flexible or stretchable components and carriers, to effectively provide high-performance and mechanically compliant electronic circuits. They call for new Conformable bioelectronic systems are promising tools that may aid the understanding of diseases, alleviate pathological symptoms such as chronic pain, heart arrhythmia, and dysfunctions, and assist in reversing conditions such as deafness, blindness, and paralysis. Combining reduced invasiveness with advanced electronic functions, hybrid bioelectronic systems have evolved tremendously in the last decade, pushed by progress in materials ...

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ReStore: A wireless peripheral nerve stimulation system

Cited by 32 publications

References 39 publications

Flat electrode contacts for vagus nerve stimulation

Flat electrode contacts for vagus nerve stimulation

Wireless and battery-free technologies for neuroengineering

Conformable Hybrid Systems for Implantable Bioelectronic Interfaces

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