2022
DOI: 10.1038/s41419-022-05398-0
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Restoration of WT1/miR-769-5p axis by HDAC1 inhibition promotes MMT reversal in mesenchymal-like mesothelial cells

Abstract: Histone acetylation/deacetylation play an essential role in modifying chromatin structure and in regulating cell plasticity in eukaryotic cells. Therefore, histone deacetylase (HDAC) pharmacological inhibitors are promising tools in the therapy of fibrotic diseases and in cancer. Peritoneal fibrosis is a pathological process characterized by many cellular and molecular alterations, including the acquisition of invasive/pro-fibrotic abilities by mesothelial cells (MCs) through induction of mesothelial to mesenc… Show more

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Cited by 12 publications
(8 citation statements)
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“…Treatment of MCs with MS-275 was confirmed to revert the EMT/MMT state toward an epithelial-like phenotype, as previously demonstrated in biological contexts not related to viral infections ( Shah et al., 2014 ; Rossi et al., 2018 ; Bontempi et al., 2022 ). The apparently paradoxical observation of induction of Snail in a frame of MMT reversal may be interpreted with the help of a previous study showing upregulated Snail expression coupled with functional inactivation upon MS-275 treatment in MCs ( Rossi et al., 2018 ).…”
Section: Discussionsupporting
confidence: 80%
“…Treatment of MCs with MS-275 was confirmed to revert the EMT/MMT state toward an epithelial-like phenotype, as previously demonstrated in biological contexts not related to viral infections ( Shah et al., 2014 ; Rossi et al., 2018 ; Bontempi et al., 2022 ). The apparently paradoxical observation of induction of Snail in a frame of MMT reversal may be interpreted with the help of a previous study showing upregulated Snail expression coupled with functional inactivation upon MS-275 treatment in MCs ( Rossi et al., 2018 ).…”
Section: Discussionsupporting
confidence: 80%
“…However, a number of challenges still need to be addressed to achieve these goals. But it is promising and feasible in the future thanks to the latest breakthroughs in the biotechnology of gene therapy [ 24 , 75 , 76 ].…”
Section: Discussionmentioning
confidence: 99%
“…However, there has been a recent increase in intensive research focusing on miRNAs, and it is anticipated that significant advances will be made in their therapeutic potential 61 . Bontempi et al loaded miR-769-5p into mesothelial cell-derived exosomes, inhibiting organ fibrosis by blocking the mesothelial-to-mesenchymal transition 62 . Bheri et al loaded miR-126 into cKit+ progenitor cells to ameliorate myocardial infarction 63 .…”
Section: Exosomes For Therapeutic Agent Deliverymentioning
confidence: 99%