Restoration of miR-30a expression inhibits growth, tumorigenicity of medulloblastoma cells accompanied by autophagy inhibition

Singh, Satishkumar; Dakhole, Aditi Nigam; Deogharkar, Akash; Kazi, Sadaf; Kshirsagar, Rohan; Goel, Atul; Moiyadi, Aliasgar; Jalali, Rakesh; Epari, Sridhar; Gupta, Tejpal; Shetty, Prakash; Gadewal, Nikhil; Shirsat, Neelam

doi:10.1016/j.bbrc.2017.07.140

Cited by 40 publications

(31 citation statements)

References 18 publications

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“…Furthermore, recent studies have found that miR-30 family could inhibit tumor cell growth, which was related to the change of tumor cell autophagy. For example, Singh et al found that the restoration of miR-30a weakened the tumorigenesis of medulloblastoma cells, accompanied with a decreased expression in Beclin 1 and the inhibition of autophagy [ 14 ]. Moreover, Zhang et al found that miR-30d could inhibit autophagy of colon cancer cells by directly targeting messenger RNA of autophagy related protein 5 (ATG5), Beclin 1, and phosphoinositide 3-kinase (PI3K), thereby promoting cell apoptosis [ 15 ].…”

Section: Mir-30 Family and Clinical Diseasesmentioning

confidence: 99%

miR-30 Family: A Promising Regulator in Development and Disease

Mao

Liu

et al. 2018

BioMed Research International

109

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MicroRNAs (miRNAs) are small noncoding RNAs that negatively regulate posttranscriptional expression of target genes. Accumulating evidences have demonstrated that the miR-30 family, as a member of microRNAs, played a crucial regulating role in the development of tissues and organs and the pathogenesis of clinical diseases, which indicated that it may be a promising regulator in development and disease. This review aims to clarify the current progress on the regulating role of miR-30 family in tissues and organs development and related disease and highlight their research prospective in the future.

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Section: Mir-30 Family and Clinical Diseasesmentioning

confidence: 99%

miR-30 Family: A Promising Regulator in Development and Disease

Mao

Liu

et al. 2018

BioMed Research International

109

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“…This could be reversed by CQ therapy, which induces starvation-induced autophagy. Therefore, miR-30a could be considered as a treatment approach for medulloblastoma, via suppressing autophagy, reversing the malignant phenotype, and reducing survival of cancer cells [236]. Table 2 lists some of the various miRNAs that have been associated with autophagy in brain tumors.…”

Section: Development Of Therapeutic Drugsmentioning

confidence: 99%

Autophagy in cancers including brain tumors: role of MicroRNAs

et al. 2020

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Autophagy has a crucial role in many cancers, including brain tumors. Several types of endogenous molecules (e.g. microRNAs, AKT, PTEN, p53, EGFR, and NF1) can modulate the process of autophagy. Recently miRNAs (small noncoding RNAs) have been found to play a vital role in the regulation of different cellular and molecular processes, such as autophagy. Deregulation of these molecules is associated with the development and progression of different pathological conditions, including brain tumors. It was found that miRNAs are epigenetic regulators, which influence the level of proteins coded by the targeted mRNAs with any modification of the genetic sequences. It has been revealed that various miRNAs (e.g., miR-7-1-3p, miR-340, miR-17, miR-30a, miR-224-3p, and miR-93), as epigenetic regulators, can modulate autophagy pathways within brain tumors. A deeper understanding of the underlying molecular targets of miRNAs, and their function in autophagy pathways could contribute to the development of new treatment methods for patients with brain tumors. In this review, we summarize the various miRNAs, which are involved in regulating autophagy in brain tumors. Moreover, we highlight the role of miRNAs in autophagy-related pathways in different cancers.

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“…Consistently with the findings that: (1) Dicer supports proper cerebellar development (Constantin et al, 2013) and curbs MB formation (Zindy et al, 2015) and (2) its ablation impairs the expression of cell cycle regulator genes in MB (Liu et al, 2017), a plethora of miRNAs were described as modulators of cell homeostasis in MB. They mainly affect cell proliferation, differentiation, and apoptosis (Li K. K. et al, 2013;Li et al, 2015;Jin et al, 2014;Xu et al, 2014;Pal and Greene, 2015;Panwalkar et al, 2015;Salm et al, 2015;Senfter et al, 2019;Yang et al, 2019), as well as senescence (Venkataraman et al, 2010) and autophagy (Singh et al, 2017).…”

Section: Mir-124 and Cell Cycle Regulationmentioning

confidence: 99%

The Non-coding Side of Medulloblastoma

Laneve

Caffarelli

2020

Front. Cell Dev. Biol.

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Medulloblastoma (MB) is the most common pediatric brain tumor and a primary cause of cancer-related death in children. Until a few years ago, only clinical and histological features were exploited for MB pathological classification and outcome prognosis. In the past decade, the advancement of high-throughput molecular analyses that integrate genetic, epigenetic, and expression data, together with the availability of increasing wealth of patient samples, revealed the existence of four molecularly distinct MB subgroups. Their further classification into 12 subtypes not only reduced the wellcharacterized intertumoral heterogeneity, but also provided new opportunities for the design of targets for precision oncology. Moreover, the identification of tumorigenic and self-renewing subpopulations of cancer stem cells in MB has increased our knowledge of its biology. Despite these advancements, the origin of MB is still debated, and its molecular bases are poorly characterized. A major goal in the field is to identify the key genes that drive tumor growth and the mechanisms through which they are able to promote tumorigenesis. So far, only protein-coding genes acting as oncogenic drivers have been characterized in each MB subgroup. The contribution of the non-coding side of the genome, which produces a plethora of transcripts that control fundamental biological processes, as the cell choice between proliferation and differentiation, is still unappreciated. This review wants to fill this major gap by summarizing the recent findings on the impact of non-coding RNAs in MB initiation and progression. Furthermore, their potential role as specific MB biomarkers and novel therapeutic targets is also highlighted.

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Restoration of miR-30a expression inhibits growth, tumorigenicity of medulloblastoma cells accompanied by autophagy inhibition

Cited by 40 publications

References 18 publications

miR-30 Family: A Promising Regulator in Development and Disease

miR-30 Family: A Promising Regulator in Development and Disease

Autophagy in cancers including brain tumors: role of MicroRNAs

The Non-coding Side of Medulloblastoma

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