Restoration of hepatocytes function following decompression therapy in extrahepatic biliary obstructed patients: Metabolite profiling of bile by NMR

Bala, Lakshmi; Tripathi, Parul; Choudhuri, Gourdas; Khetrapal, C. L.

doi:10.1016/j.jpba.2011.04.010

Cited by 7 publications

(6 citation statements)

References 46 publications

(59 reference statements)

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“…PBD provides both a prognostic and therapeutic benefit since it can provide tissue for pathological investigation and helps restore hepatocyte function. 3 , 14 The usual timing required for the restoration of hepatocyte functions after PBD is approximately 2 weeks. 14 However, the restoration time may be delayed in some patients.…”

Section: Introductionmentioning

confidence: 99%

“… 3 , 14 The usual timing required for the restoration of hepatocyte functions after PBD is approximately 2 weeks. 14 However, the restoration time may be delayed in some patients. The restoration of hepatocyte function can be delayed by prolonged biliary obstruction prior to drainage, infection, and any background of liver disease.…”

Section: Introductionmentioning

confidence: 99%

“…The restoration of hepatocyte function can be delayed by prolonged biliary obstruction prior to drainage, infection, and any background of liver disease. 14 , 15 Regarding any association between the restoration of the patient’s liver and hemodynamic function from the prolonged biliary obstruction with the outcome following PD, there are only a few studies investigating the association between the rate of bilirubin decrease and the outcome of PD. 16 , 17 Thus, the aim of this study is to investigate the rate of bilirubin decrease after PBD in periampullary tumor patients, and whether the rate of the bilirubin decrease affects the outcome following PD.…”

Section: Introductionmentioning

confidence: 99%

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Association of the rate of bilirubin decrease with major morbidity in patients undergoing preoperative biliary drainage before pancreaticoduodenectomy

et al. 2021

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Objective: The objective of this study was to examine the relationship between the rate of bilirubin decrease following preoperative biliary drainage before pancreaticoduodenectomy and postoperative morbidity. Methods: Records of patients who underwent pancreaticoduodenectomy at the Department of Surgery in Ramathibodi Hospital between January 2008 and December 2019 were retrospectively reviewed. The patients were classified into either an adequate or inadequate drainage rate groups according to the bilirubin decrease rate. Major morbidity was defined as higher than grade II in the Clavien-Dindo classification. Risk factors for major morbidity were analyzed by logistic regression analysis. Results: In total, 166 patients were included in the study. Major morbidity was observed in 36 patients (21.6%). Adequate biliary drainage rate was observed in 39 patients (23.4%). Patients who had major morbidity were less likely to have come from the adequate biliary drainage rate group than the inadequate group (38.9% vs. 61.1%). However, through multivariate logistic analysis, only body mass index, operative time, and pancreatic duct diameter were independent factors associated with major morbidity, whereas the bilirubin decrease rate was not. Conclusions: Bilirubin decrease rate following preoperative biliary drainage has no significant association with major postoperative morbidity after pancreaticoduodenectomy.

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Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Association of the rate of bilirubin decrease with major morbidity in patients undergoing preoperative biliary drainage before pancreaticoduodenectomy

et al. 2021

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“…Functional recovery after decompression is not immediate in animal models, with persistent short-term hepatocytic insufficiency. [17][18][19] Steatosis and portal inflammation were significantly associated with age in the general population and did not differ between groups. This suggested that non-alcoholic fatty liver disease (NAFLD) had a greater influence on these changes than did biliary conditions.…”

Section: Discussionmentioning

confidence: 92%

Effect of transient obstructive cholestasis on liver histology: a cross-sectional study

et al. 2021

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BACKGROUND: The role of transient obstructive cholestasis on liver histology remains undetermined. OBJECTIVE: To investigate whether transient cholestasis impairs liver histology. DESIGN AND SETTING: Cross-sectional study at a public university hospital (UNICAMP), Brazil. METHODS: 169 individuals undergoing cholecystectomy, with or without cholestasis. were enrolled. Histopathological findings were correlated with clinical and biochemical characteristics. RESULTS: Biliary hepatopathy was more frequent in individuals with resolved cholestasis than in those with active obstruction or no jaundice (P < 0.01), as also were fibrosis and ductular proliferation (P = 0.02). Cholestasis was commoner in individuals with resolved obstruction than in those with no history (P < 0.01) or active cholestasis (P < 0.05). Biliary hepatopathy was associated with longer duration of cholestasis (P < 0.001) and higher bilirubin levels (P = 0.02) in individuals with active obstruction; with lower body mass index (P = 0.02) and longer cholestasis (P < 0.001) in individuals with resolved obstruction; and with longer cholestasis (P < 0.001) and longer interval between endoscopic retrograde cholangiopancreatography and surgery (P = 0.03) overall. In individuals with active obstruction, duration of cholestasis (R = 0.7; P < 0.001) and bilirubin levels (R = 0.6; P = 0.004) were independently correlated with cholestasis severity. Duration of cholestasis (R = 0.7; P < 0.001) was independently correlated with ductular proliferation severity. CONCLUSIONS: Transient cholestasis was associated with significant histopathological changes, even after its resolution. Longer duration of obstruction correlated with greater severity of histopathological changes, especially cholestasis and ductular proliferation. This emphasizes the need for early treatment of obstructive cholestasis.

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“…Some symptoms of cholestasis (CS) are known to decrease after its relief [4]. CS complicated by hyperprolactinemia (HPL) is the model of CS of pregnancy.…”

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confidence: 99%

Possible Recovery of Manifestation of Prolactin Receptor and Some of Its Target Proteins in the Liver and Kidney Cells of Female Rats after Relief of Cholestasis Complicated and Not Complicated by Hyperprolactinemia

2015

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Immunohistochemistry with semi-quantitative analysis of computer images showed that prolactin receptor and cystic fi brosis transmembrane regulator (CFTR) in cholangiocytes of female rats elevated in cholestasis quickly respond to its relief. The effect of hyperprolactinemia on the extent of return of these proteins to baseline was different. Decompression of the bile duct abolishes the negative effect of hyperprolactinemia on CFTR expression and its positive effect on mrp3 expression in the proximal renal tubules. In renal medulla, mrp2 expression decreased when cholestasis was induced against the background of hyperprolactinemia and increases after its removal. Prolactin receptors and CFTR in cholangiocytes are most susceptible to the decrease in bile duct pressure. Changes in the expression of the studied proteins after cholestasis relief are apparently associated with attenuated toxicity of the products removed by the kidneys, which abolishes the effects of prolactin.

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Restoration of hepatocytes function following decompression therapy in extrahepatic biliary obstructed patients: Metabolite profiling of bile by NMR

Cited by 7 publications

References 46 publications

Association of the rate of bilirubin decrease with major morbidity in patients undergoing preoperative biliary drainage before pancreaticoduodenectomy

Association of the rate of bilirubin decrease with major morbidity in patients undergoing preoperative biliary drainage before pancreaticoduodenectomy

Effect of transient obstructive cholestasis on liver histology: a cross-sectional study

Possible Recovery of Manifestation of Prolactin Receptor and Some of Its Target Proteins in the Liver and Kidney Cells of Female Rats after Relief of Cholestasis Complicated and Not Complicated by Hyperprolactinemia

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