Restoration of Glutamatergic Transmission by Dopamine D4 Receptors in Stressed Animals

Yuen, Eunice Y.; Zhong, Ping; Li, Xiangning; Wei, Jing; Yan, Zhen

doi:10.1074/jbc.m112.396648

Cited by 18 publications

(14 citation statements)

References 54 publications

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“…This increase lasted for at least 24 h and was mediated via glucocorticoid receptors (GRs) in cortical pyramidal cells. The acute stress-induced increases in AMPA receptor-mediated EPSCs has been replicated by the same group several times (Yuen et al, 2011 , 2012 ), and in addition the same research group observed increases in the firing rate of PFC pyramidal neurons after acute stress (Yuen et al, 2013 ). Thus, it seems clear that acute stress is associated with an increase in glutamatergic neurotransmission.…”

Section: Arc In Mdd-related Animal Modelsmentioning

confidence: 83%

A critical evaluation of the activity-regulated cytoskeleton-associated protein (Arc/Arg3.1)'s putative role in regulating dendritic plasticity, cognitive processes, and mood in animal models of depression

Pehrson

Waller

et al. 2015

Front. Neurosci.

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Major depressive disorder (MDD) is primarily conceptualized as a mood disorder but cognitive dysfunction is also prevalent, and may limit the daily function of MDD patients. Current theories on MDD highlight disturbances in dendritic plasticity in its pathophysiology, which could conceivably play a role in the production of both MDD-related mood and cognitive symptoms. This paper attempts to review the accumulated knowledge on the basic biology of the activity-regulated cytoskeleton-associated protein (Arc or Arg3.1), its effects on neural plasticity, and how these may be related to mood or cognitive dysfunction in animal models of MDD. On a cellular level, Arc plays an important role in modulating dendritic spine density and remodeling. Arc also has a close, bidirectional relationship with postsynaptic glutamate neurotransmission, since it is stimulated by multiple glutamatergic receptor mechanisms but also modulates α-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (AMPA) receptor internalization. The effects on AMPA receptor trafficking are likely related to Arc's ability to modulate phenomena such as long-term potentiation, long-term depression, and synaptic scaling, each of which are important for maintaining proper cognitive function. Chronic stress models of MDD in animals show suppressed Arc expression in the frontal cortex but elevation in the amygdala. Interestingly, cognitive tasks depending on the frontal cortex are generally impaired by chronic stress, while those depending on the amygdala are enhanced, and antidepressant treatments stimulate cortical Arc expression with a timeline that is reminiscent of the treatment efficacy lag observed in the clinic or in preclinical models. However, pharmacological treatments that stimulate regional Arc expression do not universally improve relevant cognitive functions, and this highlights a need to further refine our understanding of Arc on a subcellular and network level.

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Section: Arc In Mdd-related Animal Modelsmentioning

confidence: 83%

A critical evaluation of the activity-regulated cytoskeleton-associated protein (Arc/Arg3.1)'s putative role in regulating dendritic plasticity, cognitive processes, and mood in animal models of depression

Pehrson

Waller

et al. 2015

Front. Neurosci.

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“…Activation of D4-receptors has a bidirectional influence on PFC neurons, namely sensitizing those that are silent by reducing network inhibition while inhibiting those that are active by preventing recurrent activation of dominant neural ensembles, thereby homeostatically regulating PFC arousal (Wang et al, 2003;Seamans and Yang, 2004;Yuen et al, 2010, Yuen andYan, 2011;Yuen et al, 2013). This is the exact opposite of D1-receptor dynamics in the PFC.…”

Section: Mesocortical Da and Goal-directed Behavior In Primary Psychomentioning

confidence: 95%

Mesocorticolimbic dopamine functioning in primary psychopathy: A source of within-group heterogeneity

Yildirim

Derksen

2015

Psychiatry Research

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“…Importantly, the ‘dopamine (DA)’ D4 receptor binds both NE and DA and thus should be considered a generalized catecholamine receptor, likely playing a role in noradrenergic function (Van Tol et al, 1991). While evidence strongly implicates D4 receptor signaling in cognition (Furth et al, 2013; Yuen et al, 2013; Zhong and Yan, 2014), our understanding of the cognitive actions of NE signaling at this receptor is limited.…”

Section: Ne and The Pfcmentioning

confidence: 99%

Differential cognitive actions of norepinephrine a2 and a1 receptor signaling in the prefrontal cortex

Berridge

Spencer

2016

Brain Research

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The prefrontal cortex (PFC) supports cognitive and behavioral processes that guide goal directed behavior. Moreover, dysregulated prefrontal cognitive dysfunction is associated with multiple psychiatric disorders. Norepinephrine (NE) signaling in the PFC is a critical modulator of prefrontal cognition and is targeted by a variety of drugs used to treat PFC-dependent cognitive dysfunction. Noradrenergic modulation of PFC-dependent cognition is complex, with concentration and receptor-specific actions that are likely dependent on neuronal activity state. Recent studies indicate that within the PFC, noradrenergic α1 and α2 receptors exert unique modulatory actions across distinct cognitive processes that allow for context-dependent modulation of cognition. Specifically, high affinity post-synaptic α2 receptors, engaged at moderate rates of NE release associated with moderate arousal levels, promote working memory. In contrast, lower affinity α1 receptors, engaged at higher rates of release associated with high arousal conditions (e.g. stress), impair working memory performance while promoting flexible attention. While these and other observations were initially interpreted to indicate high rates of NE release promotes the transition from focused to flexible/scanning attention, recent findings indicate that α1 receptors promote both focused and flexible attention. Collectively, these observations indicate that while α2 and α1 receptors in the PFC differentially modulate distinct cognitive processes, this cannot be simply ascribed to differential roles of these receptors in ‘focused’ vs. ‘flexible’ cognitive processes. Translationally, this information indicates that: 1) not all tests of prefrontal cognitive function may be appropriate for preclinical programs aimed at specific PFC-dependent disorders and 2) the treatment of specific PFC cognitive deficits may require the differential targeting of noradrenergic receptor subtypes.

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Restoration of Glutamatergic Transmission by Dopamine D4 Receptors in Stressed Animals

Cited by 18 publications

References 54 publications

A critical evaluation of the activity-regulated cytoskeleton-associated protein (Arc/Arg3.1)'s putative role in regulating dendritic plasticity, cognitive processes, and mood in animal models of depression

A critical evaluation of the activity-regulated cytoskeleton-associated protein (Arc/Arg3.1)'s putative role in regulating dendritic plasticity, cognitive processes, and mood in animal models of depression

Mesocorticolimbic dopamine functioning in primary psychopathy: A source of within-group heterogeneity

Differential cognitive actions of norepinephrine a2 and a1 receptor signaling in the prefrontal cortex

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