Restoration of Foveal Thickness and Architecture After Macula-Off Retinal Detachment Repair

dell’Omo, Roberto; Viggiano, D.; Giorgio, Dario; Filippelli, Mariaelena; Iorio, Roberto; Calo, Rocco; Cardone, Michele; Rinaldi, Michele; dell’Omo, Ermanno; Costagliola, Ciro

doi:10.1167/iovs.14-15633

Cited by 65 publications

(87 citation statements)

References 26 publications

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“…Two recent studies reported the thickness of retinal layers was significantly thinned after successful attachment and gradually increased, with only EZ-RPE thickness remaining thinner than the opposite, unaffected eye at 12 months postoperatively. 28,29 Our results corroborate those findings.…”

Section: Discussionsupporting

confidence: 92%

“…Previous studies 28,29 evaluated the relationship between improvements in BCVA and thickness of EZ-RPE or ELM-EZ at particular time points postoperatively FIGURE 3. Changes in mean retinal layer thickness are shown in eyes with macula-off RRD after surgery and corresponding control eyes.…”

Section: Discussionmentioning

confidence: 99%

“…Dell'Omo et al 28 and Terauchi et al 29 performed serial evaluations of changes in retinal layer thickness at the same location with SD-OCT and observed progressive increases in the thickness of several central retinal layers. However, assessments of the relationship between retinal layer thickness and vision were limited in those studies.…”

mentioning

confidence: 99%

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Association Between Photoreceptor Regeneration and Visual Acuity Following Surgery for Rhegmatogenous Retinal Detachment

Kobayashi

Iwase

Yamamoto

et al. 2016

Invest. Ophthalmol. Vis. Sci.

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PURPOSE. The purpose of this study was to evaluate foveal regeneration and the association between retinal restoration and visual acuity following reattachment surgery for rhegmatogenous retinal detachment (RRD).METHODS. Twenty-nine eyes of 29 patients with successfully reattached macula-off RRD were retrospectively analyzed. We used spectral-domain optical coherence tomography to image macular regions and measure retinal thickness and Snellen chart visual acuity (VA) to evaluate best-corrected VA (BCVA) at 1, 2, 3, 6, 9, and 12 months after vitrectomy. Best-corrected visual acuity data were converted to the logarithm of the minimum angle of resolution scale. Opposite eyes were used as controls.RESULTS. The thicknesses of the external limiting membrane (ELM)-ellipsoid zone (EZ) and EZretinal pigment epithelium (RPE) were significantly thinner in involved eyes than in corresponding unaffected eyes at 1 month after surgery (P < 0.001 for both), and the thickness increased over time (P < 0.001 for both). Best-corrected visual acuity significantly improved over time (P < 0.001), and the improvement correlated with EZ-RPE thickness (r ¼ À0.45, P ¼ 0.021). Multiple regression analysis demonstrated the presence of a foveal bulge as the independent predictor of final BCVA (P < 0.001). Eyes with a foveal bulge had significantly better BCVA and greater EZ-RPE thickness than those without throughout the follow-up period. Significant restoration of the integrity of EZ and cone interdigitation zone (CIZ) was observed over time (P < 0.001 for both) in eyes with a foveal bulge.CONCLUSIONS. The thickness of EZ-RPE and cone density increased during foveal regeneration, as demonstrated by the continuous improvements in CIZ integrity over time, leading to the formation of foveal bulge and good vision following successful reattachment of macula-off RRD.

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Section: Discussionsupporting

confidence: 92%

Section: Discussionmentioning

confidence: 99%

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Association Between Photoreceptor Regeneration and Visual Acuity Following Surgery for Rhegmatogenous Retinal Detachment

Kobayashi

Iwase

Yamamoto

et al. 2016

Invest. Ophthalmol. Vis. Sci.

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“…The visual acuity in the gas group was not statistically different from the visual function in the SiO group. Recent SD-OCT studies in macula-off RRD revealed that the postoperative visual acuity correlates with thickness and especially structural integrity of the outer retinal layers (e.g., external limiting membrane, ellipsoid zone, cone interdigitation zone) [27,28] . These morphological parameters may interfere with a possible deterioration of the visual function due to retinal thinning of the inner layers and makes evaluation of reported visual loss after SiO tamponade difficult [16][17][18][19][20][21][22][23][24]29] .…”

Section: Discussionmentioning

confidence: 99%

Thinning of Inner Retinal Layers after Vitrectomy with Silicone Oil versus Gas Endotamponade in Eyes with Macula-Off Retinal Detachment

Purtskhvanidze¹,

Hillenkamp²,

Tode³

et al. 2017

Ophthalmologica

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Purpose: To evaluate retinal layer thickness with optical coherence tomography (OCT) in eyes with macula-off retinal detachment after silicone oil (SiO) or gas endotamponade. Procedures: Cross-sectional study of 40 eyes with macula-off rhegmatogenous retinal detachment that underwent vitrectomy. 20 eyes received SiO tamponade and 20 matched eyes received gas. 33 healthy fellow eyes served as controls. Macular spectral domain OCT was performed with automated layer detection in the 5 inner subfields of the Early Treatment Diabetic Retinopathy Study (ETDRS) map. Results: Comparing the SiO group with the gas group, the ganglion cell layer showed a significant thinning in all fields of the inner ring of the ETDRS map, the inner plexiform layer in the nasal, superior and temporal quadrants, and the outer plexiform layer in the nasal quadrant. Conclusions: Inner retinal layers in the fovea/parafovea were significantly thinner in the SiO group. Prospective studies are warranted to further elucidate possible retinal adverse effects of SiO tamponade.

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“…Other studies quantitatively analyzed photoreceptor restoration over time after repair of RD. 15,16 Investigators have also described the dependence of photoreceptor recovery on the integrity of the external limiting membrane (ELM) after RD repair, [17][18][19] whereas others have shown that IS/OS layer restoration is independent of ELM integrity. 12,20 We performed a retrospective, quantitative SD-OCT study to examine the course of photoreceptor volumetric changes in patients with macula-off RDs after successful repair.…”

mentioning

confidence: 99%

Longitudinal Quantitative Evaluation of Photoreceptor Volume Following Repair of Macula-Off Retinal Detachment

Narala

Scarinci

Shaarawy

et al. 2016

Retina

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Restoration of Foveal Thickness and Architecture After Macula-Off Retinal Detachment Repair

Cited by 65 publications

References 26 publications

Association Between Photoreceptor Regeneration and Visual Acuity Following Surgery for Rhegmatogenous Retinal Detachment

Association Between Photoreceptor Regeneration and Visual Acuity Following Surgery for Rhegmatogenous Retinal Detachment

Thinning of Inner Retinal Layers after Vitrectomy with Silicone Oil versus Gas Endotamponade in Eyes with Macula-Off Retinal Detachment

Longitudinal Quantitative Evaluation of Photoreceptor Volume Following Repair of Macula-Off Retinal Detachment

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