Restoration of arsenite induced hepato-toxicity by crude tannin rich fraction of Theobroma cacao in Sprague Dawley rats

Chandronitha, Chandranayagam; Gayathri, Veeraraghavan; Subash, Ananthi; Vasanthi, Hannah R.

doi:10.1016/j.foodres.2012.09.021

Cited by 15 publications

(9 citation statements)

References 55 publications

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“…The findings are similar to many other studies . These studies show that arsenic has an important oxidant effect and increases the formation of free radicals and decreases the efficiency of antioxidants, thus significantly increasing MDA levels . In the boron + arsenic group, a significant MDA level decrease was determined in blood and tissues compared to the arsenic group.…”

Section: Discussionsupporting

confidence: 90%

“…Birri et al [42] stated that separations were shaped in the Bowman capsule together with disorders in the cortex of kidney tissue and that the spoiling of tubular epithelium cells were shaped in rats given arsenic. It was also clear that antioxidant materials decreased the pathological changes in tissues against arsenic exposure [35,41]. Similarly, the present study determined that boron demonstrates antioxidant properties that have a protective effect against disorders caused by arsenic exposure.…”

Section: Discussionsupporting

confidence: 73%

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The Effects of Boron on Arsenic-Induced Lipid Peroxidation and Antioxidant Status in Male and Female Rats

Küçükkurt

İnce

Demirel

et al. 2015

J Biochem Mol Toxicol

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The aim of the present study was to investigate the possible protective effects of boron, an antioxidant agent, against arsenic-induced oxidative stress in male and female rats. In total, 42 Wistar albino male and female rats were divided into three equal groups: The animals in the control group were given normal drinking water, the second group was given drinking water with 100 mg/L arsenic, and the third group was orally administered drinking water with 100 mg/kg boron together with arsenic. At the end of the 28-day experiment, arsenic increased lipid peroxidation and damage in the tissues of rats. However, boron treatment reversed this arsenic-induced lipid peroxidation and activities of antioxidant enzymes in rats. Moreover, boron exhibited a protective action against arsenic-induced histopathological changes in the tissues of rats. In conclusion, boron was found to be effective in protecting rats against arsenic-induced lipid peroxidation by enhancing antioxidant defense mechanisms.

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Section: Discussionsupporting

confidence: 90%

Section: Discussionsupporting

confidence: 73%

The Effects of Boron on Arsenic-Induced Lipid Peroxidation and Antioxidant Status in Male and Female Rats

Küçükkurt

İnce

Demirel

et al. 2015

J Biochem Mol Toxicol

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“…Therefore, identifying the role Kupffer cells play in arsenic intoxication would aid understanding the mode of toxicity. The present study by Several studies have implicated arsenic for lipid peroxidation, oxidative stress as well as liver damage (Zaki et al 2011;Chandranayagam et al 2013). Arsenic's reactivity toward sulfhydryl groups may affect several cellular functions.…”

Section: Discussionmentioning

confidence: 50%

Inhibition of Kupffer cell functions modulates arsenic intoxication in Wistar rats

Adeyemi

Meyakno²,

Akanji³

2017

gpb

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Study determined the influence of the inhibition of Kupffer cell functions by GdCl3 in arsenic intoxication. Twenty-four Wistar rats weighing between 150 and 160 g were randomly assigned into four groups. Group 1 received sodium arsenite (1.5 mg/kg b.w.) once a day, Group 2 received GdCl3 (2 mg/kg b.w.) once, 24 hours before commencing the arsenite (1.5 mg/kg b.w.) treatment. Group 3 received GdCl3 (2 mg/kg b.w.) once and subsequently given distilled water. Group 4 received distilled water only. The treatments were daily by oral gavage and lasted for 28 days. Animals were euthanized 24 hours after the last treatment. Arsenic exposure elevated the activities of rat plasma AST, ALT, ALP and γ-GT, indicative of liver injury. Arsenic exposure in rat lowered GSH concentration but potentiated inflammation and oxidative stress evidenced in the raised levels of MPO, NO and MDA. Rats with arsenic exposure were predisposed to atherosclerosis, lowering the HDL-C but elevated the LDL-C concentration. The histopathological assessment showed degenerating cellular lesion caused by arsenic. However, the inhibition of Kupffer cell functions by GdCl3 suppressed arsenic intoxication improving the liver function indices, oxidative stress status, lipid profile, neutrophilic inflammation and ultimately restored the cellular architecture. Data suggest that specific inhibition of Kupffer cells by GdCl3 protected against arsenic intoxication.

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“…The conventional treatments for arsenic-induced toxicity in patients are thiol containing chelating agents such as British Anti Lewisite (BAL; 2,3-dimercaprol), meso 2,3-dimercaptosuccinic acid (DMSA) and 2,3 dimercaptopropane-1-sulfonate (DMPS) (Flora et al, 2009;Chandranayagam et al, 2013). However, the use of these drugs is still limited due to accompanying adverse effects.…”

Section: Issn: 2320-5407mentioning

confidence: 99%

In Vitro Antioxidant Activities of Ethanolic Extract and Triterpenoid Fraction of Garcinia Kola Stem Bark and Inhibition of Arsenic-Induced Rat Liver and Kidney Mitochondrial Membrane Permeability Transitions.

Anyasor¹,

Ajagunna.²

2017

IJAR

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Restoration of arsenite induced hepato-toxicity by crude tannin rich fraction of Theobroma cacao in Sprague Dawley rats

Cited by 15 publications

References 55 publications

The Effects of Boron on Arsenic-Induced Lipid Peroxidation and Antioxidant Status in Male and Female Rats

The Effects of Boron on Arsenic-Induced Lipid Peroxidation and Antioxidant Status in Male and Female Rats

Inhibition of Kupffer cell functions modulates arsenic intoxication in Wistar rats

In Vitro Antioxidant Activities of Ethanolic Extract and Triterpenoid Fraction of Garcinia Kola Stem Bark and Inhibition of Arsenic-Induced Rat Liver and Kidney Mitochondrial Membrane Permeability Transitions.

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