Restless legs syndrome, sleep impairment, and fatigue in chronic obstructive pulmonary disease

Cavalcante, Antonio George; Bruin, Pedro Felipe Carvalhedo de; Bruin, Veralice Meireles Sales de; Pereira, Eanes Delgado Barros; Cavalcante, Marina Medeiros; Nunes, Deuzilane Muniz; Viana, Cynthia

doi:10.1016/j.sleep.2012.03.017

Cited by 42 publications

(33 citation statements)

References 38 publications

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“…It was found that RLS symptoms began after the age of 40 years in most of the patients and RLS patients had lower creatinine levels, poorer sleep quality, more fatigue, and more depressive symptoms. Moreover, ferritin levels and the severity of dyspnea were found to be correlated with the severity of RLS symptoms (11). In our study, RLS was detected in 17 (34%) of 50 COPD patients without a comorbid disease and a history of drug usage that could cause RLS.…”

Section: Discussionsupporting

confidence: 54%

“…Some factors such as disease symptoms, drugs that are used, disease-related anxiety, hypoxia, and hypercapnia are the primary factors that decrease sleep duration and quality (12). Cavalcante et al (11) found in their study that poor sleep quality was one of the important problems in COPD patients and that there was a strong relationship between poor sleep quality and the severity of dyspnea and low creatinine levels. The relationship between impaired sleep quality and RLS was evaluated in the study of Lo Coco et al (10).…”

Section: Discussionmentioning

confidence: 99%

“…Studies show that sleep disorders, including having difficulty in falling and staying asleep, insomnia, waking in the night, hypersomnia, obstructive sleep apnea syndrome, and nocturnal oxygen desaturation, are frequently found in these patients (8). In the literature, there are a few studies investigating the frequency of RLS in COPD patients (9)(10)(11)(12). While an increased frequency of RLS was detected compared to the normal population in three studies (9)(10)(11), no statistically significant difference was found in another study conducted on COPD patients without an additional disease (12).…”

Section: Introductionmentioning

confidence: 99%

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Impact of Restless Legs Syndrome on the Sleep Quality in Chronic Obstructive Pulmonary Disease

İn¹,

Turgut²,

Özdemir³

2016

Eurasian J Pulmonol

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Objective: It is well known that various sleep disorders are common in cases of chronic obstructive pulmonary disease (COPD). However, restless legs syndrome (RLS) has not been extensively studied in these patients. The aim of the current study was to investigate the prevalence of RLS and its impact on sleep quality in patients with COPD. Methods:The study included a total of 50 patients with COPD with a mean age of 67.2±7.7 years; 39 (78%) were male. The RLS diagnosis was made based on the questionnaire items standardized by the International RLS study group. Dyspnea severity (mMRC), quality of life (CAT), sleep quality [Pittsburgh sleep quality index (PSQI)], and daytime sleepiness [Epworth sleepiness scale (ESS)] were evaluated using certain specific questionnaires. The subjects were studied in two groups: RLS-positive and RLS-negative groups. Results:In the study population, RLS was detected in 17 (34%) patients. It was found that the RLS-positive subjects had a longer disease duration (p=0.006), a higher hospital admission rate (p=0.008), and lower spirometric values (p=0.023 for FVC; p=0.001 for FEV 1 ). The CAT score was significantly higher in the RLS-positive group (p=0.019). The RLS-positive group had higher PSQI and ESS scores (p<0.001 for both). There were negative correlations between PSQI, ESS scores, and spirometric measures (FVC and FEV 1 ), whereas PSQI and ESS scores had positive correlations with disease duration, mMRC, and CAT scores. Conclusion:In our study, it was observed that RLS is a common condition in patients with COPD. As the duration and severity of COPD increases, RLS becomes more prevalent and sleep quality deteriorates.

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Section: Discussionsupporting

confidence: 54%

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Impact of Restless Legs Syndrome on the Sleep Quality in Chronic Obstructive Pulmonary Disease

İn¹,

Turgut²,

Özdemir³

2016

Eurasian J Pulmonol

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“…Then again, fatigue and dyspnea were reduced by a physical training program for 13 weeks [30] . Cavalcante et al [31] found in chronic obstructive pulmonary disease patients that a high degree of dyspnea on the MRC scale was an independent risk factor for poor subjective sleep quality on the Pittsburgh Sleep Quality Index (PSQI) and was, at the same time, positively correlated with the severity of fatigue.…”

Section: Discussionmentioning

confidence: 99%

Fatigue and Excessive Daytime Sleepiness in Sarcoidosis: Prevalence, Predictors, and Relationships between the Two Symptoms

et al. 2017

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Background: Fatigue is common among patients with sarcoidosis. The etiology of this problem is unknown and multifactorial. Fatigue can be confounded with excessive daytime sleepiness (EDS). Fatigue and sleepiness have rarely been studied simultaneously in sarcoidosis patients. Objectives: The aim of this study was the confounder-adjusted estimation of risks for severe fatigue and EDS in a large population of sarcoidosis patients and the development of multivariate predictors from this population. Methods: 1,197 German sarcoidosis patients were examined using the Epworth Sleepiness Scale (ESS), the Fatigue Assessment Scale (FAS), the Hospital Anxiety and Depression Scale (HADS), and the Medical Research Council (MRC) dyspnea scale. Results: 16.5% (123 patients) had EDS (ESS ≥16), 16.4% had severe fatigue (FAS ≥35), and 6.3% had both extreme findings. In a multivariate logistic regression model, predictors of the risk of EDS were a history of sleep apnea (odds ratio [OR] 2.46, 95% confidence interval [CI] 1.5-3.9), dyspnea MRC grade ≥2 (OR 2.29, 95% CI 1.5-3.5), and organ involvement of 4-7 organs (OR 1.60, 95% CI 1.1-2.4). Significantly associated with higher risk of severe fatigue were the following: conspicuous depression (OR 5.95, 95% CI 4.1-8.7), conspicuous anxiety (OR 2.38, 95% CI 1.6-3.4), and muscle pain (OR 1.92, 95% CI 1.32-2.75). The logit models for severe fatigue with and without simultaneous EDS differed only slightly. Conclusion: An extreme form of fatigue and/or sleepiness was found in 27% of all sarcoidosis patients questioned. Because there is a certain overlap, both should be examined simultaneously to allow for a combined assessment.

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“…48 First, RLS is prevalent in various respiratory conditions including asthma, emphysema, bronchiolitis, 38 and recipients of lung transplants, 49 and the incidence is as high as 50% during acute exacerbations of chronic obstructive lung disease. 50,51 Second, patients suffering from coronary artery disease and heart failure often experience RLS, 52 with questionable participation of sympathetic hyperactivity in PLM. 53 Third, peripheral vascular disease precipitates RLS.…”

Section: Associated Disordersmentioning

confidence: 99%

Restless Leg Syndrome in Neurologic and Medical Disorders

Askenasy¹,

Askenasy

2015

Sleep Medicine Clinics

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Restless legs syndrome, sleep impairment, and fatigue in chronic obstructive pulmonary disease

Cited by 42 publications

References 38 publications

Impact of Restless Legs Syndrome on the Sleep Quality in Chronic Obstructive Pulmonary Disease

Impact of Restless Legs Syndrome on the Sleep Quality in Chronic Obstructive Pulmonary Disease

Fatigue and Excessive Daytime Sleepiness in Sarcoidosis: Prevalence, Predictors, and Relationships between the Two Symptoms

Restless Leg Syndrome in Neurologic and Medical Disorders

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