Restless Legs Syndrome in Patients with Hypertension and Diabetes Mellitus

Sabic, Adela; Sinanović, Osman; Sabic, Dzevad; Galić, Gordan

doi:10.5455/medarh.2016.70.116-118

Cited by 15 publications

(13 citation statements)

References 17 publications

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“…Previous studies from other countries found lower rates of RLS among patients with diabetes [22][23]. A previous study showed no association of restless legs syndrome with type 2 diabetes in contradiction to the current findings [24]. The different rates of RLS may be explained by other comorbidities and study types [25].…”

Section: Discussioncontrasting

confidence: 99%

Restless Legs Syndrome Among Sudanese Patients With Type 2 Diabetes Mellitus: A Case-Control Study

Mirghani¹

2020

Cureus

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Background There is increasing awareness about the association of restless legs syndrome (RLS) with type 2 diabetes. This study assessed RLS and its associations among patients with diabetes. Material and methods This case-control study was conducted among 160 subjects (82 patients with diabetes and 78 controls) attending a diabetic clinic in Omdurman, Sudan, during the period from June 2018 to September 2019. A structured questionnaire was used to collect demographic factors, diabetic neuropathy, nephropathy, retinopathy, and macrovascular complications. The neck circumference was measured to assess adiposity, and a blood sample was taken for the glycated hemoglobin (HbA1 c) estimation. The local ethical committee approved the research, and the Statistical Package for Social Sciences (SPSS; IBM Corp., Armonk, NY) was used for data analysis. A P-value of <0.05 was considered significant. Results There were 82 patients with type 2 diabetes and 78 controls matched for age and sex. Restless legs syndrome was higher among patients with diabetes (31.7% vs. 10.3%%) with a significant statistical difference, P-<0.05. A direct positive relationship was found between restless legs syndrome and diabetic neuropathy (Wald=5.48, P-value=0.019, 95%CI 1.70-410.76), no relationship was found between RLS, diabetic retinopathy, glycated hemoglobin, sex, and neck circumference, P-values (0.757, 0.804, 0.317, and 0.361 respectively). Conclusion Restless legs syndrome was prevalent among patients with type 2 diabetes and was more common among patients with diabetic neuropathy, no relationship was found between restless legs syndrome, age, sex, neck circumference, HbA1 c , and retinopathy

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Section: Discussioncontrasting

confidence: 99%

Restless Legs Syndrome Among Sudanese Patients With Type 2 Diabetes Mellitus: A Case-Control Study

Mirghani¹

2020

Cureus

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“…In this study, diabetic patients reported high prevalence of RLS (22.8%), and this is confirmative with other studies conducted in Iran (19.5%),[8] Bosnia and Herzegovina (21%),[13] the United States (24.5%),[5] Brazil (27%),[11] and Turkey (28.3%). [6] This result supports the study findings of other studies[1314161718] that sleep disorders correlate highly with hypertension and diabetic population in the present study.…”

Section: Discussionsupporting

confidence: 91%

“…Iron deficiency is a well-known condition correlating with several forms of symptomatic RLS in the diabetic population; our study was in consistent with a previously reported study that showed an association between RLS and iron status in diabetic patients. [19] The association between RLS and hypertension and heart diseases could be due to the effects of a prolonged sleep loss in increasing the probability of developing hypertension and diabetes,[1314161718] which may lead to vascular diseases.…”

Section: Discussionmentioning

confidence: 99%

“…At present, many experimental and epidemiological studies have reported that poor sleep quantity and quality are related to greater prevalence of high fasting plasma glucose and high HbA1c level. [11121314] Most recently, studies have been reported that long durations of sleep are associated with severity of diabetes. [15161718] Many studies provided evidence that sleep quality influences the glycemic control among patients with type 2 diabetes mellitus (T2DM) and approximately 37%–50% of patients with T2DM have sleep problems, which is higher than the general population.…”

Section: Introductionmentioning

confidence: 99%

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The prevalence of restless legs syndrome and comorbid condition among patient with type 2 diabetic mellitus visiting primary healthcare

Bener

Al-Hamaq

Ağan

et al. 2019

J Family Med Prim Care

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Aim:The aim of this study was to determine the prevalence of restless legs syndrome (RLS) and Pittsburgh Sleep Quality Index (PSQI) in patients with type 2 diabetes mellitus (T2DM) attending primary healthcare.Subjects and Methods:This is a cross-sectional study and participants were between 25 and 70 years old who visited the diabetes and endocrinology department of Mega Medipol University Teaching Hospital, Istanbul. The diagnosis of RLS was performed according to the International Restless Legs Syndrome Study Group consensus criteria. The RLS and PSQI instruments were conducted on 871 patients with T2DM. Good sleep quality was defined as PSQI score <5. RLS severity was assessed by the Restless Legs Syndrome-6 Scales (RLS-6). The scale development and validation was carried out using Rasch measurement model.Results:The prevalence of RLS was 22.8% including 60.3% of females and 39.7% of males. This study showed significant differences between RLS and no RLS patients with respect to their age (years), body mass index (BMI) (kg/m2), physical activity, smoking habit, sheesha smoking, income, and sleeping quality with PSQI. Also, the analysis presented that statistically significant differences between both RLS and no RLS reported sleep complaints including difficulty falling asleep, inadequate sleep, anytime fatigue, and leg discomfort. There were statistically significant differences between RLS and no RLS patients regarding hypoglycemia, numbness in legs, retinopathy, neuropathy, nephropathy high blood pressure, depression, stroke, anemia, diabetic foot, ulcer, arthritis, respiratory disease, metabolic syndrome, and coronary heart disease. Furthermore, there were statistically significant differences between RLS and no RLS concerning the number of sleeping hours, wake-up time (AM), sleeping time (PM), BMI (kg/m2), HbA1c, vitamin D, calcium, creatinine, fasting blood glucose, low-density lipoprotein, triglyceride, uric acid, and systolic and diastolic blood pressure (mmHg).Conclusion:This study confirms positive relation and high prevalence of RLS among patients with T2DM visiting primary healthcare. The results suggest that physical activity is associated with a better perception of functional capacity and pain in diabetic patients with RLS, and thus a more active lifestyle should be encouraged.

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“…Previous studies from other countries found lower rates of RLS among patients with diabetes [22,23]. A previous study [24] showed no association of the restless leg syndrome with type 2 diabetes in contradiction to the current findings. The different rates of RLS may be explained by other comorbidities and study type [25].…”

Section: The Relationship Of the Restless Syndrome (No=26) To Sex Necontrasting

confidence: 99%

Restless leg syndrome among Sudanese patients with type 2 diabetes mellitus: A case-control study

Mirghani¹

2020

Preprint

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Objectives: There is an increasing awareness about the association of the restless leg syndrome (RLS) with type 2 diabetes, the present study assessed RLS and its associations among patients with diabetes. Results: This case-control study conducted among 160 subjects (eighty-two patients with diabetes and 78 controls) attending a diabetic clinic in Omdurman, Sudan during the period from June 2018 to September 2019. A structured questionnaire based on restless syndrome, demographic data, and diabetes complications was used. The neck circumference was measured to assess adiposity, and a blood sample was taken for the glycated hemoglobin estimation.There were 82 patients with type 2 diabetes and 78 controls matched for age and sex, the restless syndrome was higher among patients with diabetes (31.7% vs. 10.3%%) with significant statistical difference, P-<0.05, A direct positive relationship was found between restless leg syndrome and diabetic neuropathy (Wald =5.48, P-value=0.019, 95% CI 1.70-410.76, no relationship was found between RLS, diabetic retinopathy, HbA1 c , sex, and neck circumference, P-values (0.757, 0.804, 0.317, and 0.361 respectively). RLS was prevalent among patients with type 2 diabetes and related to diabetic neuropathy, no relationship was found between restless syndrome, age, sex, neck circumference, HbA1 c , and retinopathy.

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Restless Legs Syndrome in Patients with Hypertension and Diabetes Mellitus

Cited by 15 publications

References 17 publications

Restless Legs Syndrome Among Sudanese Patients With Type 2 Diabetes Mellitus: A Case-Control Study

Restless Legs Syndrome Among Sudanese Patients With Type 2 Diabetes Mellitus: A Case-Control Study

The prevalence of restless legs syndrome and comorbid condition among patient with type 2 diabetic mellitus visiting primary healthcare

Restless leg syndrome among Sudanese patients with type 2 diabetes mellitus: A case-control study

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