Restless legs syndrome in patients with multiple sclerosis: evaluation of risk factors and clinical impact

Hernández, Lucía Lebrato; León, María Prieto; Fuentes, Nathalie; Sánchez, Antonio José Uclés; Chocán, J L Casado; Sánchez, María Díaz

doi:10.1016/j.nrleng.2018.12.018

Cited by 6 publications

(3 citation statements)

References 30 publications

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“…Sleep apnea and insomnia in the general population is associated with greater incidence of work related disability. [74][75][76][77] People with multiple sclerosis with sleep apnea or RLS have greater disability, 78,79 higher levels of fatigue, 80 and lower quality of life 81 than people with multiple sclerosis without these sleep disorders. In people with traumatic brain injury, insomnia is associated with poorer quality of life as well.…”

Section: Discussionmentioning

confidence: 99%

The Impact of Sleep Disorders on Functional Recovery and Participation Following Stroke: A Systematic Review and Meta-Analysis

Fulk

Boyne

Hauger

et al. 2020

Neurorehabil Neural Repair

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Background Adequate sleep is vital for health and quality of life. People with stroke and a concomitant sleep disorder may have poorer outcomes than those without a sleep disorder. Objective To systematically evaluate the published literature to determine the impact of sleep disorders on physical, functional recovery at the activity and participation level after stroke. Methods A systematic review was conducted using PubMed, CINAHL, Scopus, and PsycINFO. Studies were selected that reported outcomes on physical, functional recovery at the activity and participation levels in participants with stroke and a diagnosed sleep disorder. A meta-analysis was performed on included studies that reported Barthel Index (BI) and modified Rankin Scale (mRS) scores. Results: A total of 33 studies were included in the systematic review with 9 of them in the meta-analysis. The mean mRS score was 0.51 points higher in participants with stroke and sleep disorders versus participants with stroke without sleep disorder [95% CI: 0.23-0.78]. The mean BI score was 10.2 points lower in participants with stroke and sleep disorders versus participants with stroke without sleep disorder [95% CI: −17.9 to −2.6]. Conclusions People with stroke and a sleep disorder have greater functional limitations and disability than those without a sleep disorder. Rehabilitation professionals should screen their patients with stroke for potential sleep disorders and further research is needed to develop sleep and rehabilitation interventions that can be delivered in combination. PROSPERO registration number: CRD42019125562.

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Section: Discussionmentioning

confidence: 99%

The Impact of Sleep Disorders on Functional Recovery and Participation Following Stroke: A Systematic Review and Meta-Analysis

Fulk

Boyne

Hauger

et al. 2020

Neurorehabil Neural Repair

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“…Restless legs syndrome is a common disorder according to most of the epidemiological studies performed in both general and specific disease populations (Ferini‐Strambi, Walters, & Sica, 2014; Khachatryan, Ghahramanyan, Tavadyan, Yeghiazaryan, & Attarian, 2020; Lebrato Hernández et al, 2022; Manconi et al, 2021; Trenkwalder et al, 2016). Overall, the prevalence of RLS in the general population ranges from 2.5% to around 10% (Garcia‐Borreguero et al, 2006).…”

Section: Epidemiology Of Rlsmentioning

confidence: 99%

Restless legs syndrome: Over 50 years of European contribution

Khachatryan

Ferri

Fulda

et al. 2022

Journal of Sleep Research

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Summary Restless legs syndrome (RLS) is a sensorimotor neurological disorder characterised by an urge to move the limbs with a circadian pattern (occurring in the evening/at night), more prominent at rest, and relieved with movements. RLS is one of the most prevalent sleep disorders, occurring in 5%–10% of the European population. Thomas Willis first described RLS clinical cases already in the 17th century, and Karl‐Axel Ekbom described the disease as a modern clinical entity in the 20th century. Despite variable severity, RLS can markedly affect sleep (partly through the presence of periodic leg movements) and quality of life, with a relevant socio‐economic impact. Thus, its recognition and treatment are essential. However, screening methods present limitations and should be improved. Moreover, available RLS treatment options albeit providing sustained relief to many patients are limited in number. Additionally, the development of augmentation with dopamine agonists represents a major treatment problem. A better understanding of RLS pathomechanisms can bring to light novel treatment possibilities. With emerging new avenues of research in pharmacology, imaging, genetics, and animal models of RLS, this is an interesting and constantly growing field of research. This review will update the reader on the current state of RLS clinical practice and research, with a special focus on the contribution of European researchers.

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“…So far, only few small studies have investigated sleep in fatigued MS patients by means of polysomnography (PSG), which represents the gold standard in sleep research. Herein, authors provided conflicting results, with respiratory disturbances, restless legs syndrome (RLS) and quantitative abnormalities in sleep architecture being associated with fatigue in some but not in other studies [ 8 , 11 , 12 , 13 , 14 ].…”

Section: Introductionmentioning

confidence: 99%

Contribution of sleep disturbances to fatigue in multiple sclerosis: a prospective study using clinical and polysomnographic parameters

Riccitelli

Disanto

Sacco

et al. 2021

Euro J of Neurology

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Restless legs syndrome in patients with multiple sclerosis: evaluation of risk factors and clinical impact

Cited by 6 publications

References 30 publications

The Impact of Sleep Disorders on Functional Recovery and Participation Following Stroke: A Systematic Review and Meta-Analysis

The Impact of Sleep Disorders on Functional Recovery and Participation Following Stroke: A Systematic Review and Meta-Analysis

Restless legs syndrome: Over 50 years of European contribution

Contribution of sleep disturbances to fatigue in multiple sclerosis: a prospective study using clinical and polysomnographic parameters

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