Restless Legs Syndrome in Patients with Chronic Obstructive Pulmonary Disease

Kaplan, Yuksel; Inonu, Handan; Yılmaz, Ayşe; Öcal, Serpil

doi:10.1017/s0317167100008957

Cited by 40 publications

(33 citation statements)

References 16 publications

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“…RLS was associated with severe hypoxia and hypercapnia in two studies, and in one of these studies, it was found to be associated with the severity of airway obstruction (10,19). Moreover, it was reported that RLS was more frequent in patients with longer follow-up periods for COPD (9,10). In our study, the duration of disease was longer and obstruction was more severe in patients with RLS.…”

Section: Discussionsupporting

confidence: 60%

“…Studies show that sleep disorders, including having difficulty in falling and staying asleep, insomnia, waking in the night, hypersomnia, obstructive sleep apnea syndrome, and nocturnal oxygen desaturation, are frequently found in these patients (8). In the literature, there are a few studies investigating the frequency of RLS in COPD patients (9)(10)(11)(12). While an increased frequency of RLS was detected compared to the normal population in three studies (9)(10)(11), no statistically significant difference was found in another study conducted on COPD patients without an additional disease (12).…”

Section: Introductionmentioning

confidence: 99%

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Impact of Restless Legs Syndrome on the Sleep Quality in Chronic Obstructive Pulmonary Disease

İn¹,

Turgut²,

Özdemir³

2016

Eurasian J Pulmonol

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Objective: It is well known that various sleep disorders are common in cases of chronic obstructive pulmonary disease (COPD). However, restless legs syndrome (RLS) has not been extensively studied in these patients. The aim of the current study was to investigate the prevalence of RLS and its impact on sleep quality in patients with COPD. Methods:The study included a total of 50 patients with COPD with a mean age of 67.2±7.7 years; 39 (78%) were male. The RLS diagnosis was made based on the questionnaire items standardized by the International RLS study group. Dyspnea severity (mMRC), quality of life (CAT), sleep quality [Pittsburgh sleep quality index (PSQI)], and daytime sleepiness [Epworth sleepiness scale (ESS)] were evaluated using certain specific questionnaires. The subjects were studied in two groups: RLS-positive and RLS-negative groups. Results:In the study population, RLS was detected in 17 (34%) patients. It was found that the RLS-positive subjects had a longer disease duration (p=0.006), a higher hospital admission rate (p=0.008), and lower spirometric values (p=0.023 for FVC; p=0.001 for FEV 1 ). The CAT score was significantly higher in the RLS-positive group (p=0.019). The RLS-positive group had higher PSQI and ESS scores (p<0.001 for both). There were negative correlations between PSQI, ESS scores, and spirometric measures (FVC and FEV 1 ), whereas PSQI and ESS scores had positive correlations with disease duration, mMRC, and CAT scores. Conclusion:In our study, it was observed that RLS is a common condition in patients with COPD. As the duration and severity of COPD increases, RLS becomes more prevalent and sleep quality deteriorates.

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Section: Discussionsupporting

confidence: 60%

Section: Introductionmentioning

confidence: 99%

Impact of Restless Legs Syndrome on the Sleep Quality in Chronic Obstructive Pulmonary Disease

İn¹,

Turgut²,

Özdemir³

2016

Eurasian J Pulmonol

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“…Spillane reported on the presence of severe RLS in eight COPD patients referred for neurological evaluation [22]. A subsequent study reported an increased prevalence of RLS (29.1%) in 134 patients with COPD [12]. In this study, the RLS diagnosis was associated with the more pronounced hypercapnia and hypoxia occurring in advanced stages of COPD.…”

Section: Discussionmentioning

confidence: 47%

“…In accordance with the hypothesis stating that pain threshold may be modified by hypoxia, there is data demonstrating a high prevalence of pain and RLS in patients with COPD and sleep-disordered breathing [9,[12][13][14]. However, the majority of existing evidence is based on data from clinical cohorts.…”

Section: Introductionmentioning

confidence: 93%

Chronic pulmonary disease is associated with pain spreading and restless legs syndrome in middle-aged women—a population-based study

et al. 2018

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Introduction Recent studies suggest an increased prevalence of chronic pain conditions and restless legs syndrome (RLS) in patients with chronic pulmonary disease (CPD). We analyzed the prevalence and risk factors for pain and RLS in a populationbased sample of females with comorbid CPD. Method Questionnaire-based data from 2745 women aged 18-64 years were analyzed regarding comorbid CPD status (severe bronchitis, emphysema, asthma). Pain status was assessed according to symptoms reflecting severity (Visual Analogue Scale, VAS rating 0-10) and duration and spreading (limited spread or widespread) of pain. A diagnosis of RLS was defined by four validated diagnostic criteria. Anthropometrics and co-morbidities were assessed as covariates in univariate and multivariate analyses. Results Widespread pain was overrepresented in women with CPD (44.6 vs. 24.6%, p < 0.001). The odds ratio for widespread pain in women with CPD was 1.6 (95% confidence interval (CI) 1.2-2.2, p < 0.001) in the fully adjusted model. Severe pain (VAS rating ≥ 7) was more prevalent in females with known CPD (28.8 vs. 15.4%, p < 0.001, odd ratio 1.4 (95% CI 1.0-1.9, p = 0.029)). The prevalence of RLS was 37.4 and 23.8% in subjects with or without CPD, respectively (p < 0.001). In multivariate analysis, CPD was associated with a 30% risk increase for RLS (odds ratio 1.3 (95% CI 1.0-1.7, p = 0.04)). Conclusion This population-based study identified CPD as an independent risk factor for severe and widespread pain as well as for RLS. Further research addressing pathophysiological mechanisms linking CPD and chronic pain conditions/ RLS is warranted.

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“…Indeed, a 3-4 times higher risk of RLS has been found in COPD. [9][10][11] Conversely, a large population-based study of COPD found significantly more COPD in individuals with RLS, as defined by spirometry. 12 Clinically, it is important to note that peripheral neuropathy is common in COPD and can mimic RLS, but it probably does not fully account for the increased prevalence.…”

Section: Disclosure Statementmentioning

confidence: 98%

Restless Legs Syndrome: What Have We Learned from Prevalence Studies and How Will Incidence Studies Further Clinical Knowledge?

Picchietti

Picchietti²

2012

Journal of Clinical Sleep Medicine

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C o m m e n t a R YR estless legs syndrome (RLS), also known as Willis-Ekbom disease, is now generally appreciated in the medical literature as common and complex. Over 50 prevalence studies, most published since 2005, have been crucial in defi ning many important clinical aspects. In this issue of JCSM is one of the fi rst general population-based incidence studies of RLS. 1 How are incidence studies different, and how might they further clinical knowledge?First, let us review the "Top Five" agreed upon fi ndings from prevalence studies of RLS. 2 Number 5: Prevalence in females is about twice as high as in males, beginning in the late teens or 20s. Number 4: Association with other conditions. Individuals with RLS are at least twice as likely to have scores indicating a depressive or anxiety disorder. This has major clinical implications in that common treatments for these disorders can worsen RLS, 3 and because ongoing sleep disturbance is a known risk factor for the onset and persistence of depressive disorders, as well as for suicidality. Interestingly, emerging evidence indicates at least twice the risk of cardiovascular disease in RLS. Less agreement has been found regarding increased comorbidity with numerous other disorders, including hypertension, diabetes, and obesity. Number 3: Quality of life (QOL) impairments are signifi cant in moderate-to-severe RLS, comparable to diabetes and congestive heart failure. 4 These include lower physical and mental health scores, with disturbed sleep very common by both subjective and objective measures. Number 2: There is a wide spectrum of frequency/severity. Of those meeting the four essential IRLSSG criteria, application of frequency at least 1x/week represents 60% of the RLS population; at least 2x/week is about 50%; and daily is about 20%. Clinically signifi cant RLS-RLS associated with higher morbidity and where treatment should be considered-can be defi ned by frequency/severity measures. Occurrence at least 1-2x/week, typically with moderate to severe distress, is the most common defi nition in the epidemiologic studies that show impairment.Number 1: Consideration of differential diagnosis is very important. Exclusion of "mimics" of RLS, such as leg cramps, positional discomfort, arthritis, and leg edema, leads to specifi city of diagnosis, 5 and prevalence rates of 1.9% to 4.6% for moderate-to-severe RLS in European and North American studies. 2 Without differential diagnosis prevalence estimates are about 1.25 to 2 times higher. Importantly, the 2012 revision of the International RLS Study Group (IRLSSG) diagnostic criteria will include differential diagnosis as a 5 th essential criterion, as is also planned for the International Classifi cation of Sleep Disorders (ICSD-3) and the Diagnostic and Statistical Manual of Mental Disorders (DSM-5) in 2013.Incidence rate is an estimate of the number of new cases in a population over a given time period, as compared to prevalence, which estimates the total number of cases in a population at a given time. Incidence pr...

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Restless Legs Syndrome in Patients with Chronic Obstructive Pulmonary Disease

Cited by 40 publications

References 16 publications

Impact of Restless Legs Syndrome on the Sleep Quality in Chronic Obstructive Pulmonary Disease

Impact of Restless Legs Syndrome on the Sleep Quality in Chronic Obstructive Pulmonary Disease

Chronic pulmonary disease is associated with pain spreading and restless legs syndrome in middle-aged women—a population-based study

Restless Legs Syndrome: What Have We Learned from Prevalence Studies and How Will Incidence Studies Further Clinical Knowledge?

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