Restless Legs Syndrome in Iranian People With Type 2 Diabetes Mellitus: The Role in Quality of Life and Quality of Sleep

Modarresnia, Leila; Golgiri, Fatemeh; Madani, Nahid Hashemi; Emami, Zahra; Tanha, Kiarash

doi:10.5664/jcsm.6938

Cited by 21 publications

(33 citation statements)

References 42 publications

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“…In this study, diabetic patients reported high prevalence of RLS (22.8%), and this is confirmative with other studies conducted in Iran (19.5%),[8] Bosnia and Herzegovina (21%),[13] the United States (24.5%),[5] Brazil (27%),[11] and Turkey (28.3%). [6] This result supports the study findings of other studies[1314161718] that sleep disorders correlate highly with hypertension and diabetic population in the present study.…”

Section: Discussionsupporting

confidence: 91%

“…[456] RLS can have profound negative effects on the quality of life and daily activities and is associated with significant economic, social, and healthcare burdens. [78910] RLS has been significantly associated with diabetes, hypertension, obesity, and metabolic syndrome;[56] meanwhile, the situation and role of these relationships remain unclear.…”

Section: Introductionmentioning

confidence: 99%

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The prevalence of restless legs syndrome and comorbid condition among patient with type 2 diabetic mellitus visiting primary healthcare

Bener

Al-Hamaq

Ağan

et al. 2019

J Family Med Prim Care

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Aim:The aim of this study was to determine the prevalence of restless legs syndrome (RLS) and Pittsburgh Sleep Quality Index (PSQI) in patients with type 2 diabetes mellitus (T2DM) attending primary healthcare.Subjects and Methods:This is a cross-sectional study and participants were between 25 and 70 years old who visited the diabetes and endocrinology department of Mega Medipol University Teaching Hospital, Istanbul. The diagnosis of RLS was performed according to the International Restless Legs Syndrome Study Group consensus criteria. The RLS and PSQI instruments were conducted on 871 patients with T2DM. Good sleep quality was defined as PSQI score <5. RLS severity was assessed by the Restless Legs Syndrome-6 Scales (RLS-6). The scale development and validation was carried out using Rasch measurement model.Results:The prevalence of RLS was 22.8% including 60.3% of females and 39.7% of males. This study showed significant differences between RLS and no RLS patients with respect to their age (years), body mass index (BMI) (kg/m2), physical activity, smoking habit, sheesha smoking, income, and sleeping quality with PSQI. Also, the analysis presented that statistically significant differences between both RLS and no RLS reported sleep complaints including difficulty falling asleep, inadequate sleep, anytime fatigue, and leg discomfort. There were statistically significant differences between RLS and no RLS patients regarding hypoglycemia, numbness in legs, retinopathy, neuropathy, nephropathy high blood pressure, depression, stroke, anemia, diabetic foot, ulcer, arthritis, respiratory disease, metabolic syndrome, and coronary heart disease. Furthermore, there were statistically significant differences between RLS and no RLS concerning the number of sleeping hours, wake-up time (AM), sleeping time (PM), BMI (kg/m2), HbA1c, vitamin D, calcium, creatinine, fasting blood glucose, low-density lipoprotein, triglyceride, uric acid, and systolic and diastolic blood pressure (mmHg).Conclusion:This study confirms positive relation and high prevalence of RLS among patients with T2DM visiting primary healthcare. The results suggest that physical activity is associated with a better perception of functional capacity and pain in diabetic patients with RLS, and thus a more active lifestyle should be encouraged.

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Section: Discussionsupporting

confidence: 91%

Section: Introductionmentioning

confidence: 99%

The prevalence of restless legs syndrome and comorbid condition among patient with type 2 diabetic mellitus visiting primary healthcare

Bener

Al-Hamaq

Ağan

et al. 2019

J Family Med Prim Care

View full text Add to dashboard Cite

show abstract

“…In the present study, restless leg syndrome was found in 31.7% of patients compared to 10.3% of control subjects, the present finding was higher than the result of (Harashima et al [20] (8%), The current findings were similar to a study published by Zobeiri et al [21] who concluded a prevalence of 28.6% compared to 7.1% in control subjects. Previous studies from other countries found lower rates of RLS among patients with diabetes [22,23]. A previous study [24] showed no association of the restless leg syndrome with type 2 diabetes in contradiction to the current findings.…”

Section: The Relationship Of the Restless Syndrome (No=26) To Sex Necontrasting

confidence: 99%

Restless leg syndrome among Sudanese patients with type 2 diabetes mellitus: A case-control study

Mirghani¹

2020

Preprint

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Objectives: There is an increasing awareness about the association of the restless leg syndrome (RLS) with type 2 diabetes, the present study assessed RLS and its associations among patients with diabetes. Results: This case-control study conducted among 160 subjects (eighty-two patients with diabetes and 78 controls) attending a diabetic clinic in Omdurman, Sudan during the period from June 2018 to September 2019. A structured questionnaire based on restless syndrome, demographic data, and diabetes complications was used. The neck circumference was measured to assess adiposity, and a blood sample was taken for the glycated hemoglobin estimation.There were 82 patients with type 2 diabetes and 78 controls matched for age and sex, the restless syndrome was higher among patients with diabetes (31.7% vs. 10.3%%) with significant statistical difference, P-<0.05, A direct positive relationship was found between restless leg syndrome and diabetic neuropathy (Wald =5.48, P-value=0.019, 95% CI 1.70-410.76, no relationship was found between RLS, diabetic retinopathy, HbA1 c , sex, and neck circumference, P-values (0.757, 0.804, 0.317, and 0.361 respectively). RLS was prevalent among patients with type 2 diabetes and related to diabetic neuropathy, no relationship was found between restless syndrome, age, sex, neck circumference, HbA1 c , and retinopathy.

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“…The current findings were similar to a study published by Zobeiri et al who concluded a prevalence of 28.6% as compared to 7.1% in control subjects [21]. Previous studies from other countries found lower rates of RLS among patients with diabetes [22][23]. A previous study showed no association of restless legs syndrome with type 2 diabetes in contradiction to the current findings [24].…”

Section: Discussionsupporting

confidence: 87%

Restless Legs Syndrome Among Sudanese Patients With Type 2 Diabetes Mellitus: A Case-Control Study

Mirghani¹

2020

Cureus

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Background There is increasing awareness about the association of restless legs syndrome (RLS) with type 2 diabetes. This study assessed RLS and its associations among patients with diabetes. Material and methods This case-control study was conducted among 160 subjects (82 patients with diabetes and 78 controls) attending a diabetic clinic in Omdurman, Sudan, during the period from June 2018 to September 2019. A structured questionnaire was used to collect demographic factors, diabetic neuropathy, nephropathy, retinopathy, and macrovascular complications. The neck circumference was measured to assess adiposity, and a blood sample was taken for the glycated hemoglobin (HbA1 c) estimation. The local ethical committee approved the research, and the Statistical Package for Social Sciences (SPSS; IBM Corp., Armonk, NY) was used for data analysis. A P-value of <0.05 was considered significant. Results There were 82 patients with type 2 diabetes and 78 controls matched for age and sex. Restless legs syndrome was higher among patients with diabetes (31.7% vs. 10.3%%) with a significant statistical difference, P-<0.05. A direct positive relationship was found between restless legs syndrome and diabetic neuropathy (Wald=5.48, P-value=0.019, 95%CI 1.70-410.76), no relationship was found between RLS, diabetic retinopathy, glycated hemoglobin, sex, and neck circumference, P-values (0.757, 0.804, 0.317, and 0.361 respectively). Conclusion Restless legs syndrome was prevalent among patients with type 2 diabetes and was more common among patients with diabetic neuropathy, no relationship was found between restless legs syndrome, age, sex, neck circumference, HbA1 c , and retinopathy

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Restless Legs Syndrome in Iranian People With Type 2 Diabetes Mellitus: The Role in Quality of Life and Quality of Sleep

Abstract: RLS has an independent and significant role in sleep quality and QoL in the patients with diabetes. Neuropathy with RLS does not confer any additive burden on QoL and sleep quality of this population of patients with diabetes.

Cited by 21 publications

References 42 publications

The prevalence of restless legs syndrome and comorbid condition among patient with type 2 diabetic mellitus visiting primary healthcare

The prevalence of restless legs syndrome and comorbid condition among patient with type 2 diabetic mellitus visiting primary healthcare

Restless leg syndrome among Sudanese patients with type 2 diabetes mellitus: A case-control study

Restless Legs Syndrome Among Sudanese Patients With Type 2 Diabetes Mellitus: A Case-Control Study

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