Restless legs syndrome in end‐stage renal disease: a multicenter study in <scp>T</scp>aiwan

Lin, Chin-Hsien; Wu, Vin Cent; Li, W.-Y.; Sy, Hiu-Ngar; Wu, Shuo‐Jye; Chang, Cheng-Chen; Chiu, Ping Fang; Lion, Hung-Hsiang; Lin, Chien‐Yu; Chang, Hao‐Yu; Lin, Shuei-Liong; Wu, Kwan‐Dun; Chen, Ming-Fong; Wu, Ruey Meei

doi:10.1111/ene.12095

Cited by 53 publications

(73 citation statements)

References 41 publications

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“…The current study found no association between diabetes and RLS, unlike the study by Lin et al (2); the reason for this discrepancy is not clear. There was no association between the abnormalities in paraclinical parameters such as anemia, hyperparathyroidism, iron status, serum albumin, and dialysis adequacy and RLS.…”

Section: Discussioncontrasting

confidence: 99%

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Restless Leg Syndrome, Insomnia, and Depression in Hemodialysis Patients: Three Sides of a Triangle?

et al. 2017

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Section: Discussioncontrasting

confidence: 99%

“…Apart from the idiopathic form, secondary RLS is associated with iron deficiency, pregnancy, the Parkinson disease, and renal failure (2).…”

Section: Introductionmentioning

confidence: 99%

Restless Leg Syndrome, Insomnia, and Depression in Hemodialysis Patients: Three Sides of a Triangle?

et al. 2017

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“…The exact pathogenic mechanisms responsible for uremic RLS/WED remain unknown. Several predisposing factors have been identified, especially the frequent occurrence of anemia in ESRD, but also low serum iron status [16], calcium/phosphate imbalance [7,17], peripheral nerve abnormalities [18] and genetic changes [12]. …”

Section: Introductionmentioning

confidence: 99%

Survival of Dialysis Patients with Restless Legs Syndrome: A 15-Year Follow-Up Study

Baiardi

Mondini²,

Antognini³

et al. 2017

Am J Nephrol

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Background: Restless legs syndrome, also known as Willis/Ekbom disease (RLS/WED), is a sleep-related, sensorimotor disorder with a high prevalence among end-stage renal disease (ESRD) patients undergoing haemodialysis (HD) (about 15-40%). Whether RLS/WED in uremic patients influences cardiovascular morbidity and mortality remains a matter of controversy. The aim of this study was to evaluate the relationship of RLS/WED and mortality in a population of chronically dialyzed patients. Method: In 1996, we studied 128 patients with ESRD undergoing HD; 47 subjects (36.7%) complained RLS/WED symptoms. Fifteen years later we evaluated the mortality of this population. No clinical follow-up examination of the uremic population was made. The Kaplan-Maier curves in dialysis patients with or without RLS/WED (control group matched for age) were constructed for all-cause mortality and compared using log-rank test. Results: The Kaplan-Maier curves disclosed a lower mortality rate in the uremic patients with RLS/WED than in those without RLS/WED (p = 0.04). In our analysis, the mortality rate was not influenced by RLS/WED severity (p = 0.11) or gender (p = 0.15). No difference among the causes of death was found in the 2 groups. Conclusions: Our study suggests that mortality in ESRD patients is not influenced by concomitant RLS/WED. After a 15-year follow-up, survival rates in our cohort were significantly longer in uremic subjects with RLS/WED than in those without RLS/WED. Finally, we found no relationship between RLS/WED severity and mortality.

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“…For example, some studies report a prevalence of 12%-25%. [101][102][103] Other studies in CKD patients (but not on dialysis) report a similar prevalence of 10%-30% regardless of CKD stage, [104][105][106][107] whereas in renal failure clinics in USA and Europe, it fluctuates from 11% to 58%. 9 In addition, PLMS may affect ~50%-70% of patients with ESRD.…”

Section: Secondary Rls/plms and Risk Of Cardiovascular Diseasementioning

confidence: 96%

Cardiovascular comorbidity in patients with restless legs syndrome: current perspectives

Vargas-Pérez¹,

Bagai²,

Walters³

2017

JPRLS

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Restless legs syndrome in end‐stage renal disease: a multicenter study in Taiwan

Abstract: Our findings demonstrated that RLS is common in Taiwanese dialysis patients. Clinicians should have a high suspicion for the presence of RLS symptoms in patients with ESRD, especially those with type 2 diabetes, anemia, low serum iron status and long duration of dialysis.

Cited by 53 publications

References 41 publications

Restless Leg Syndrome, Insomnia, and Depression in Hemodialysis Patients: Three Sides of a Triangle?

Restless Leg Syndrome, Insomnia, and Depression in Hemodialysis Patients: Three Sides of a Triangle?

Survival of Dialysis Patients with Restless Legs Syndrome: A 15-Year Follow-Up Study

Cardiovascular comorbidity in patients with restless legs syndrome: current perspectives

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