Restless Legs Syndrome and Mortality in Kidney Transplant Recipients

Molnar, Miklos Z.; Szentkirályi, András; Lindner, Anett; Czira, Maria E.; Szeifert, Lilla; Kovács, Ágnes Zsófia; Fornadi, Katalin; Szabó, András; Rosivall, László; Mucsi, István; Novák, Márta

doi:10.1053/j.ajkd.2007.08.003

Cited by 47 publications

(32 citation statements)

References 33 publications

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“…[11,19,20]. According to the IRLSSG rating scale, severity was classified as mild (<11 on the IRLSSG rating scale), moderate (11)(12)(13)(14)(15)(16)(17)(18)(19)(20), severe (21)(22)(23)(24)(25)(26)(27)(28)(29)(30), and very severe (31)(32)(33)(34)(35)(36)(37)(38)(39)(40) [21]. The Page 6 of 35 prevalence of RLS found in that study was 26.6% (154/579).…”

Section: Methodsmentioning

confidence: 96%

“…Only a few studies have reported an association between the presence and/or severity of uremic RLS and high mortality rates [12][13][14][15]. In particular, increased severity of uremic RLS has been associated with an increased incidence of cardiovascular events as well as with a higher mortality rate in patients treated with HD [15] or with a kidney transplant [14].…”

Section: Page 12 Of 35mentioning

confidence: 99%

“…Publication bias may be another reason for this contradiction. Survival studies, all positive, seem to be very scarce [12,13,15] among epidemiological surveys on RLS in HD patients [11,14,[27][28][29][30][31][32][33][34][35][36].…”

Section: Page 12 Of 35mentioning

confidence: 99%

“…Uremic RLS has been frequently associated with increased morbidity and enhanced mortality in patients with end-stage renal disease [12][13][14][15]. In the general population, however, studies of this association have reported inconsistent results.…”

Section: Introductionmentioning

confidence: 99%

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Restless legs syndrome does not affect 3-year mortality in hemodialysis patients

et al. 2015

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This is a PDF file of an unedited manuscript that has been accepted for publication. As a service to our customers we are providing this early version of the manuscript. The manuscript will undergo copyediting, typesetting, and review of the resulting proof before it is published in its final form. Please note that during the production process errors may be discovered which could affect the content, and all legal disclaimers that apply to the journal pertain. Original Highlights of the studyWe evaluated the relationship of RLS and mortality in chronic hemodialysis patients For the diagnosis of RLS we implemented standard methodology, i.e. the essential clinical criteria of the International RLS Study Group. This is the first time this issue is investigated in an epidemiological survey in Greece.In contrast to previous reports the diagnosis of RLS does not influence the 3-year mortality in HD patients. ABSTRACTObjective: In chronic hemodialysis (HD) patients, the prevalence of restless legs syndrome (RLS) is significantly higher than in the general population. Uremic RLS has been related to an enhanced mortality of HD patients. In the general population, however, studies of this association have yielded inconsistent results. The aim of the present study was to re-evaluate the relationship of RLS and mortality in HD patients. Methods:We recorded the 3-year mortality rate in a population of 579 HD patients after assessment for RLS symptoms. In addition we analyzed the 5-year mortality rate after end-stage renal disease onset (i.e., commencement of HD). This HD patient population has been previously included in a cross-sectional survey of RLS prevalence in which RLS diagnosis was based on the essential clinical criteria of the International RLS Study Group. Mortality data were acquired from the national endstage renal disease registry. Survival probability was calculated by means of the Kaplan-Meier method and analyzed by the log-rank (Mantel-Cox) test. For multivariate survival analysis, we implemented a proportional hazards regression Conclusion: Diagnosis of RLS according to the essential clinical criteria of theInternational RLS Study Group does not seem to influence the 3-year mortality in HD patients. Our findings are in contrast to those in some previous reports, and reinforce the need for further studies of RLS and mortality in HD patients.

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Section: Methodsmentioning

confidence: 96%

Section: Page 12 Of 35mentioning

confidence: 99%

Section: Page 12 Of 35mentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Restless legs syndrome does not affect 3-year mortality in hemodialysis patients

et al. 2015

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“…[32][33][34] Several potential mechanisms may account for the association between RLS and mortality. Restless legs syndrome was associated with cardiovascular diseases.…”

Section: Discussionmentioning

confidence: 99%

Untitled

Kahvecioğlu

Yıldız²,

Büyükkoyuncu³

et al. 2016

Exp Clin Transplant

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Objectives: Restless legs syndrome is a disorder in which patients have irresistible urge to move legs during rest. Restless legs syndrome seems to be common in end-stage renal disease. After a successful renal transplant, symptoms ameliorate with renal function improvement and restless legs syndrome is seen less in this population. Here, we aimed to investigate restless legs syndrome frequency and associated factors in renal transplant patients. Materials and Methods:In a cross-sectional study with 193 patients (116 hemodialysis patients, 45 transplant patients, and 32 controls), the presence of restless legs syndrome was assessed using the Restless Legs Syndrome Questionnaire. Medical history, demographic, and laboratory data were collected from the patients' medical records. Patients were questioned about the presence of restless legs syndrome using the Restless Legs Syndrome Questionnaire. Patients were evaluated with Beck Depression Scale for depression and Pittsburgh tests for sleep disturbances. Results: While the rate of restless legs syndrome was similar between transplants and controls, it was significantly greater in hemodialysis patients. Hemodialysis patients and controls had similar depression scores that were higher compared with transplant patients. Pittsburgh score was similar in transplant patients and controls and significantly increased in the hemodialysis patients. The rate of insomnia was significantly higher in the hemodialysis patients compared with the other 2 groups. Logistic regression analysis revealed independent correlates of restless legs syndrome as insomnia, Beck depression score, and being on hemodialysis. Linear regression analysis showed that independent correlates of higher Pittsburgh score were higher depression score, higher age, and presence of restless legs syndrome. Conclusions: The prevalence of restless legs syndrome is significantly lower in transplant patients than it is in patients on maintenance dialysis. In renal transplant patients, restless legs syndrome frequency was found to be lower because of improved renal functions (normalization of uremia), psychological symptoms, and sleep disturbances.

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A Review of Restless Legs Syndrome in Patients on Hemodialysis

Lee

2008

Kidney

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Restless Legs Syndrome and Mortality in Kidney Transplant Recipients

Cited by 47 publications

References 33 publications

Restless legs syndrome does not affect 3-year mortality in hemodialysis patients

Restless legs syndrome does not affect 3-year mortality in hemodialysis patients

Untitled

A Review of Restless Legs Syndrome in Patients on Hemodialysis

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