Restless legs syndrome and its relationship with anxiety, depression, and quality of life in cancer patients undergoing chemotherapy

Abstract

Introduction Extended half-life factor products have reduced annualized bleeding rates in hemophilia patients. The impact of extended half-life versus conventional factor products on hemophilia caregiver burden has not been investigated. This study aimed to evaluate caregiver burden in extended half-life versus conventional factor products for hemophilia A and B. Methods This cross-sectional web-based study of caregivers of people with hemophilia A or B was recruited from a panel research company and by word of mouth. Participants completed the Hemophilia Caregiver Impact measure, the PedsQL Family Impact Module (PedsQL), and the Work Productivity and Activity Impairment Questionnaire (WPAI). We also collected demographic, insurance coverage, and medical information related to the hemophilia patient(s). Burden differences were assessed using linear regression and matched cohort analyses. Results The sample (n = 448) included 49 people who were caring for people on extended half-life factor products. Worse caregiver burden was associated with more infusions per week and more bleeds in the past 6 months. Regression analyses suggested that caring for someone who is on a extended half-life factor product is associated with lower emotional impact (β = − 0.11, p < 0.05, Adjusted R 2 = 0.06), and shows a trend association with lower practical impact (β = − 0.09, p < 0.10, Adjusted R 2 = 0.05). The matched cohort analysis also revealed that people on extended half-life factor product had lower Emotional Impact and Practical Impact scores (t = − 2.95 and − 2.94, respectively, p < 0.05 in both cases). No differences were detected on the PedsQL or the WPAI. Conclusion The reduced required frequency of factor product infusions of extended half-life factor products appears to reduce the emotional distress and practical burden of caregiving. Future work should evaluate the longitudinal impact.

Patients Suffering from Restless Legs Syndrome Have Low Internal Locus of Control and Poor Psychological Functioning Compared to Healthy Controls

“…In this our results are in line with those reported by others [24,46], who found that quality of life was substantially affected in patients suffering from RLS compared to indices from a general population.…”

Patient-reported sleep disturbance in advanced cancer: frequency, predictors and screening performance of the Edmonton Symptom Assessment System sleep item

“…In this study, a high frequency of RLS was found in ACP 34. The exact aetiology is not clear, but use of antidepressant medications, especially the, caffeine use and anaemia (iron deficiency), are common contributors to RLS and are frequently seen in patients with advanced cancer 35.…”

Ethnic Differences in the Prevalence and Predictors of Restless Legs Syndrome between Hispanics of Mexican Descent and Non-Hispanic Whites in San Diego County: A Population-Based Study

“…Cancer pa- tients afflicted by RLS had significantly higher levels of anxiety and depression, and poorer quality of life. 49 In Koreans, having RLS was associated with depression and anxiety disorders 50 ; in uremic patients, increased anxiety levels was an independent predictor of RLS. 51 We are unable to explain from our data why only men, primarily younger men, had lower RLS prevalence than younger women, as would be suggested by previously reported higher prevalence of RLS in women.…”