Restless Legs Syndrome

Ondo, William G.

doi:10.1016/j.ncl.2005.05.003

Cited by 21 publications

(6 citation statements)

References 165 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…This receptor profile may explain the appearance of RLS one hour after drug ingestion, as seen in the literature. As well as the antihistaminic effects of quetiapine could cause RLS [41]. On the other hand, the percentage of those with RLS among SNRI + trazodone users was significantly higher than those using SNRI + quetiapine, SNRI + mirtazapine or SNRI only.…”

Section: Discussionmentioning

confidence: 91%

“…Therefore it is used just before bedtime because of its properties. Quetiapine is observed to be more related to RLS than other second-generation antipsychotics [41][42][43]. In a review of the relationship between quetiapine and RLS, seven cases were presented and six of them developed RLS with quetiapine + antidepressant drug combination [44].…”

Section: Discussionmentioning

confidence: 99%

See 1 more Smart Citation

Is restless legs syndrome related with depression/anxiety disorders or medications used in these disorders? A cross-sectional, clinic-based study

Ocak

Kotan

Paltun

et al. 2019

Psychiatry and Clinical Psychopharmacology

View full text Add to dashboard Cite

Objective: The aim of this study is to investigate the frequency and severity of restless legs syndrome (RLS) in patients diagnosed with depression or anxiety disorder and the relationship of RLS with medications used in these disorders and clinical/sociodemographic characteristics of the patients. Methods: Four hundred and fifty-four consecutive patients who were treated with medication for "Depressive Disorder" or "Anxiety Disorder" in our outpatient clinic were included in the study. Subjects were screened by International Restless Legs Syndrome Study Group (IRLSSG) scale, Hospital Anxiety Depression Scale. Patients who met the criteria of RLS diagnosis due to the RLS screening scale (n = 104) were interviewed in detail. Patients' laboratory tests were performed to investigate medical conditions other than antidepressant/antipsychotic use known to be related with RLS and 40 (8.8%) of 104 patients were excluded from the study. The main study group consisted of 414 patients. Results: The mean IRLSSG score of 64 patients diagnosed with RLS was 18.95 ± 5.11 (min: 7max: 29), 7.8% of whom had mild and 55.1% had severe RLS. The incidence of RLS in patients receiving antidepressant treatment (n: 414) was significantly higher than the general population (15.5%). There were no significant difference neither between diagnostic groups (anxiety/ depression) nor individual antidepressants by means of RLS. Patients receiving combined treatment like SSRI + quetiapine, SSRI + mirtazapine or SSRI + trazodone scored 4.7 times higher on RLS scale. Discussion: There was no significant difference by means of RLS diagnosis or severity of RLS in patients with a diagnosis of anxiety/depressive disorder. However antidepressant using patients' RLS prevalence was higher than general population's. It was noticed that patients who received combined drug treatment had a 4.7-fold increase in RLS. In conclusion; beginning with as possible as the least number and dose of psychotropic drugs when treating a patient with depression or anxiety disorder does not increase RLS risk as well as providing advantages such as reduced risk of drug interaction and side effects.

show abstract

Section: Discussionmentioning

confidence: 91%

Section: Discussionmentioning

confidence: 99%

Is restless legs syndrome related with depression/anxiety disorders or medications used in these disorders? A cross-sectional, clinic-based study

Ocak

Kotan

Paltun

et al. 2019

Psychiatry and Clinical Psychopharmacology

View full text Add to dashboard Cite

show abstract

“…Iron is a necessary cofactor for tyrosine-hydroxylase, the rate-limiting enzyme in the production of dopamine. 4 The levels of this enzyme are increased in the setting of iron deficiency and in RLS. 10 Iron is also a part of the dopamine type-2 (D2) receptor, and RLS patients have less binding of dopamine to the D2 receptor either due to a lower number of these receptors or a decrease in affinity.…”

Section: Discussionmentioning

confidence: 99%

“…It is common for patients to have difficulty describing the "uncomfortable" sensations accompanying RLS, and their descriptions are varied and education dependent. 4 Because children in particular can have difficulty describing RLS, alternate criteria have been proposed for making the diagnosis in children. Children may have the above 4 criteria along with an age-appropriate description of leg discomfort or the above 4 criteria plus 2 of the following: a sleep disturbance, a parent or sibling with RLS, and/or a sleep study showing periodic limb movement disorder.…”

Section: Discussionmentioning

confidence: 99%

Iron Deficiency Anemia, Pica, and Restless Legs Syndrome in a Teenage Girl

Starn

Udall

2007

Clin Pediatr (Phila)

View full text Add to dashboard Cite

“…Restless leg syndrome is described as "an urge to move the legs with or without paresthesia [tingling, numbness], worsening symptoms at rest, and transient improvements with activity, and worsening of symptoms in the evening and night" (32). Although primary RLS (the presence of uncomfortable leg sensations without clear association to underlying, chronic disease) has occasionally been described in the medical journals, it is a poorly understood constellation of neurological complaints that appears to often have a genetic component.…”

Section: Restless Leg Syndromementioning

confidence: 99%

“Dualities of Interest”: The Inter-Organizational Relationships between Disease-Specific Nonprofits and the Pharmaceutical Industry

Paluzzi¹

2012

Int J Health Serv

View full text Add to dashboard Cite

Health care and biomedical research environments in the United States are largely characterized by strategic relational practices conducted beyond the public gaze. The very nature of health care has been widely reconceptualized from a response to physical/biological imperatives regulated by health promotion and the epidemiological distribution of diseases to profit/market imperatives regulated by "product/brand" promotion and market dynamics. At critical decision points throughout the system, we find the multinational pharmaceutical industry wielding the influence that its wealth and power have bought. This study contributes to the growing body of work that seeks to illuminate the relationships between the pharmaceutical industry and the various entities that constitute the U.S. health and research systems. Through the use of case studies, it examines the relationships between the multinational pharmaceutical industry and the large disease-specific public and professional nonprofit organizations. It explores several questions, including: Is the concept of what constitutes a conflict of interest being purposefully manipulated? Is the public benevolence afforded to nonprofits extended to their corporate partners in ways that preclude critical oversight of relational dynamics? And are public donations, solicited by and given in good faith to these organizations, inevitably serving the economic interests and profits of donor pharmaceutical companies?

show abstract

Restless Legs Syndrome

Cited by 21 publications

References 165 publications

Is restless legs syndrome related with depression/anxiety disorders or medications used in these disorders? A cross-sectional, clinic-based study

Is restless legs syndrome related with depression/anxiety disorders or medications used in these disorders? A cross-sectional, clinic-based study

Iron Deficiency Anemia, Pica, and Restless Legs Syndrome in a Teenage Girl

“Dualities of Interest”: The Inter-Organizational Relationships between Disease-Specific Nonprofits and the Pharmaceutical Industry

Contact Info

Product

Resources

About