Restless Leg Syndrome Exacerbated by Sertraline

Hargrave, Rita; Beckley, Dennis J.

doi:10.1016/s0033-3182(98)71370-2

Cited by 64 publications

(34 citation statements)

References 3 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…A number of medications are believed to either induce or exacerbate the symptoms of RLS. 29,30 These include selective serotonin re-uptake inhibitors, tricyclic anti-depressants, nonopioid analgesics, lithium, beta-blockers, histamine-2 blockers and ethanol. There was no significant increase in the use of these medications in the RLS group compared with the non-RLS group.…”

Section: Discussionmentioning

confidence: 99%

Restless Legs Syndrome in Lung Transplant Recipients

Minai¹,

Golish²,

Yataco³

et al. 2007

The Journal of Heart and Lung Transplantation

View full text Add to dashboard Cite

Section: Discussionmentioning

confidence: 99%

Restless Legs Syndrome in Lung Transplant Recipients

Minai¹,

Golish²,

Yataco³

et al. 2007

The Journal of Heart and Lung Transplantation

View full text Add to dashboard Cite

“…A introdução do antidepressivo mirtazapina, um inibidor seletivo da captação de serotonina, acarretou piora acentuada do quadro da SPI, e a retirada da mitarzapina resultou em melhora dos sintomas. Existem vários relatos de SPI induzida por medicações antidepressivas, como a mianserina 19,20 , paroxetina 21 , fluoxetina 22 , sertralina 23 e mirtazapina 24 .…”

Section: Discussionunclassified

Síndrome das pernas inquietas com herança autossômica dominante piorada pelo uso de mirtazapina: relato de caso

Teive

Quadros

Barros

et al. 2002

Arq. Neuro-Psiquiatr.

View full text Add to dashboard Cite

RESUMO -Relatamos o caso de uma paciente de 78 anos, com diagnóstico estabelecido de síndrome das pernas inquietas (SPI), de etiologia primária com herança autossômica dominante. A paciente apresentava quadro depressivo associado. Enfatiza-se a piora do quadro clínico da SPI após o uso de anti-depressivo com ação inibidora seletiva da recaptação de serotonina (mirtazapina), com atenuação dos sintomas após a retirada da droga, e a excelente resposta terapêutica com o uso de agonista dopaminérgico (pramipexol) em baixa dose. PALAVRAS-CHAVE: síndrome das pernas inquietas, mirtazapina.Worsening of autosomal dominant restless legs syndrome after use of mirtazapine: case report ABSTRACT -We report the case of a 78 years old female patient with primary restless legs syndrome (RLS) with an autosomal dominant pattern of inheritance. In addition, the patient also had depression. We emphasize the worsening of symptoms of RLS after the use of a selective serotonin uptake inhibitor (mirtazapine), with improvement after the drug was discontinued, and an excellent recovery with the use of low dose dopaminergic agonist (pramipexol).KEY WORDS: restless legs syndrome, mirtazapine. . Um grande interesse nesta enfermidade vem sendo observado recentemente, talvez pela sua alta incidência, de até 5%, na população em geral segundo alguns estudos 1,2,4 . A falta de informação dirigida aos médicos e também o fato da sua fisiopatologia ser ainda pouco compreendida contribuem para que seja uma doença sub-diagnosticada. É caracterizada, sumariamente, pela sensação de inquietude, noturna e ao descanso, dos membros inferiores, associados a queixas de parestesias e disestesias. A insônia é uma consequência comum destes sintomas. Trata-se de doença crônica, com maior prevalência acima dos 30 anos de idade [1][2][3][4] . Porém, pode ocorrer em todas as faixas etárias. A classificação da SPI ainda é motivo de controvérsia, sendo basicamente dividida em duas categorias: idiopática (primária) e sintomática (secundária). Nas formas primá-rias pode-se encontrar formas familiares com herança autossômica dominante 1,3,4 . Neste artigo relatamos um caso da SPI com herança autossômica dominante, bem como peculiaridades do tratamento, em particular a piora do quadro clínico após o uso de droga inibidora seletiva de captação de serotonina (mirtazapina) e a excelente melhora clínica após tratamento com droga agonista dopaminérgico (pramipexol). CASOMulher, branca, com 78 anos de idade, viúva. Há 2 meses começou apresentar sensação de desconforto e parestesias nos pés, pernas e coxas, semelhantes a "formigamento", "queimação". Esses sintomas pioravam com a

show abstract

“…4,18 Recurrence and/or increase in symptoms of RLS was observed after the use of the antidepressants¯uoxetine (Prozac) and sertraline (Zoloft); both being selective serotinin re-uptake inhibitors. 115,116 Similarly, the occurrence of RLS was observed in association with mianserin, a serotonin-inhibiting antihistamine. 117 Worsening of symptoms has been described with paroxetine (Paxil), a phenylpyperidine derivative.…”

Section: 53mentioning

confidence: 97%

Restless Legs Syndrome

Glasauer

2001

Spinal Cord

View full text Add to dashboard Cite

Restless Legs Syndrome (RLS) is a well-de®ned symptom complex and is frequently associated with sleep disturbance and a recognized family history. It occurs either as idiopathic RLS or in association with many medical, neurological or vascular disorders. The neurological examination and routine investigations in idiopathic RLS are normal. Polysomnography supports the diagnosis of RLS by documenting the associated sleep disturbances and periodic limb movements in sleep (PLMS). Although MRI studies disclose no intracerebral lesions, recent Positron Emission Tomography (PET) and single photon emission computed tomography (SPECT) studies point to some involvement of the basal and red nuclei and the cerebellum. No de®nitive etiology is known for this condition, but several pathophysiological mechanisms have been proposed. There is supportive evidence that RLS is a Central Nervous System (CNS) dysfunction, suggesting widespread involvement of the descending dopaminergic (DA) pathways, possibly originating in the diencephalon or upper brainstem. This is corroborated by the successful treatment of RLS with DA agents, sedatives, and neurotransmitters. However, RLS can also occur with spinal disorders and spinal cord lesions implying the existence of a spinal generator. The incidence of RLS in pregnancy is well known and its association with vascular disorders supports another mechanism in some patients. The primary treatment of RLS is largely symptomatic and quite eective with DA agents, DA agonists, opioids and other neurotransmitters. The treatment of RLS associated with various diseases is aimed at the correction of the underlying pathological or de®ciency states. Antidepressant medications frequently precipitate or worsen the condition of RLS. Spinal Cord (2001) 39, 125 ± 133

show abstract

Restless Leg Syndrome Exacerbated by Sertraline

Cited by 64 publications

References 3 publications

Restless Legs Syndrome in Lung Transplant Recipients

Restless Legs Syndrome in Lung Transplant Recipients

Síndrome das pernas inquietas com herança autossômica dominante piorada pelo uso de mirtazapina: relato de caso

Restless Legs Syndrome

Contact Info

Product

Resources

About